Charles N. Okolo

Correction to: Integrated Safety and Efficacy Analyses of Phase 3 Trials of a Microbiome Therapeutic for Recurrent CDI

Colleen S. Kraft, Matthew Sims, Michael Silverman, Thomas Louie et autres

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Integrated Safety and Efficacy Analyses of Phase 3 Trials of a Microbiome Therapeutic for Recurrent CDI

Colleen S. Kraft, Matthew Sims, Michael Silverman, Thomas J. Louie et autres

INTRODUCTION: Recurrent Clostridioides difficile infection (rCDI) often occurs after standard-of-care antibiotics. VOWST oral spores (VOS, previously SER-109), an FDA-approved orally administered microbiome therapeutic, is indicated to prevent rCDI following antibiotics for rCDI. OBJECTIVE, DESIGN, AND PATIENTS: To evaluate safety and efficacy of …

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Effects of bile acids on dog pancreatic duct epithelial cell secretion and monolayer resistance

Charles N. Okolo, Thomas Wong, Mark W. Moody, Toan D. Nguyen

Pancreatic duct epithelial cells (PDEC) mediate the secretion of fluid and electrolytes and are exposed to refluxed bile. In nontransformed cultured dog PDEC, which express many ion transport pathways of PDEC, 1 mM taurodeoxycholic acid (TDCA) stimulated an (125)I(-) efflux inhibited by …

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Severe Gastrointestinal Bleeding After Hematopoietic Cell Transplantation, 1987–1997: Incidence, Causes, and Outcome

Jonathan M. Schwartz, John L. Wolford, Mark D. Thornquist, David M. Hockenbery et autres

OBJECTIVE: Severe GI bleeding after hematopoietic cell transplantation is commonly due to lesions that are unusual in nontransplant patients. The frequency of GI bleeding appears to have decreased over the last decade, but the reasons have not been readily apparent. We sought …

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Mast cell recruitment in chronic pancreatitis

Charles N. Okolo, Mary P. Bronner, Toan Duc Nguyen

Small intestinal pathology

Charles N. Okolo, Christina M. Surawicz

During the past year, important studies on various mechanisms of small bowel disease have been reported. The section on enterocyte function evaluates studies on hypoxia and apoptosis. Many of the studies of small intestinal epithelia use as models T84 cells. When these …

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Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2

Toan Duc Nguyen, Mark W. Moody, Martin S. Steinhoff, Charles N. Okolo et autres

Proteinase-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved by trypsin within the NH2-terminus, exposing a tethered ligand that binds and activates the receptor. We examined the secretory effects of trypsin, mediated through PAR-2, on well-differentiated nontransformed dog pancreatic duct …

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Histamine stimulates ion transport by dog pancreatic duct epithelial cells through H1receptors

Toan D. Nguyen, Charles N. Okolo, Mark W. Moody

Histamine affects pancreatic secretion, but its direct action on ion transport by pancreatic duct epithelial cells (PDEC) has not been defined. We now characterize the secretory effects of histamine on cultured, well-differentiated, and nontransformed dog PDEC. Histamine stimulated, in a concentration-dependent manner …

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Trypsin activates ion channels of dog pancreatic duct cells via proteinase-activated receptors-2

Thom Nguyen, Mark W. Moody, Charles N. Okolo

Effects of bile acids on secretion by dog pancreatic duct epithelial cells

Charles N. Okolo, Mark W. Moody, Troy Nguyen