E. Eugene Marsh

Genetic variation of human G6PD impacts Red Blood Cell transfusion efficacy

Matthew S. Karafin, Aaron Issaian, Shaun Bevers, Julie A. Reisz et autres

Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common human enzymopathy, affects 6% of the global population, yet its impact on blood storage and transfusion efficacy remains undefined. We integrated genome-metabolome-proteome analyses of 13,091 blood donors (362 G6PD SNPs), validated in a recalled cohort …

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Uncovering the Brain Circuits that Govern the Behavioral and Neuroendocrine Acute Stress Responses

E. Eugene Marsh

The body employs various tactics to face and overcome acute or short-term stress. These processes include behavioral and accompanying fine-tuned neuroendocrine responses to help individuals adapt to stress. Consequently, in instances wherein these systems are not functioning correctly, physical and psychological disease …

Restoring Faculty Vitality in Academic Medicine When Burnout Threatens

Darshana Shah, Valerie N. Williams, Luanne E. Thorndyke, E. Eugene Marsh et autres

Increasing rates of burnout-with accompanying stress and lack of engagement-among faculty, residents, students, and practicing physicians have caused alarm in academic medicine. Central to the debate among academic medicine's stakeholders are oft-competing issues of social accountability; cost containment; effectiveness of academic medicine's …

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Vertebral Morphometry: A Comparison of Long-Term Precision of Morphometric X-ray Absorptiometry and Morphometric Radiography in Normal and Osteoporotic Subjects

J A Rea, M. B. Chen, J. Li, E. Eugene Marsh et autres

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Vertebral morphometry: A comparison of long-term precision of morphometric X-ray absorptiometry and morphometric radiography in normal and osteoporotic subjects

J A Rea, M. B. Chen, Jianmei Li, E. Eugene Marsh et autres

Vertebral morphometry, the quantification of vertebral body shape, has proved a useful tool in the identification and evaluation of osteoporotic vertebral deformities in both epidemiologic surveys and clinical trials. Although conventionally it has been performed on lateral radiographs of the thoracolumbar spine …

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Intraregional decline in case-fatality and hospital use after occlusive stroke in the southeastern United States

Daniel C. Potts, Frank Gilliam, Camilo R. Gomez, E. Eugene Marsh et autres

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Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.

Harold P. Adams, Birgitte H. Bendixen, L. Jaap Kappelle, José Biller et autres

BACKGROUND AND PURPOSE: The etiology of ischemic stroke affects prognosis, outcome, and management. Trials of therapies for patients with acute stroke should include measurements of responses as influenced by subtype of ischemic stroke. A system for categorization of subtypes of ischemic stroke …

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MR imaging of spinal cord and vertebral body infarction.

William T. C. Yuh, E. Eugene Marsh, A. K. Wang, John Russell et autres

PURPOSE: To study the usefulness of MR in the evaluation of spinal cord infarctions and associated findings. MATERIALS AND METHODS: MR examinations of 12 patients (10 men and two women) were reviewed retrospectively. Onset of symptoms of spinal cord ischemia was abrupt …

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Circadian Variation in Stroke-Reply

E. Eugene Marsh, José Biller, Harold P. Adams

In Reply. —We appreciate Dr Alberts' concerns about the potential shortcomings in determining the time of onset. This is clearly an inherent problem in all clinical studies and trials that depend on a patient's or family's recollection and ability to accurately communicate …

Mortality in Acute Cerebral Infarction in Young Adults—A Ten-Year Experience

José Biller, Harold P. Adams, Askiel Bruno, Betsy B. Love et autres

We reviewed the one-month mortality among 213 patients aged fifteen to forty-five years (mean thirty-five) with acute cerebral infarction (CI) evaluated during the period July 1, 1977, to February 1, 1988. Atherosclerotic cerebral infarction (ACI) was diagnosed in 59 (27.7%) patients, 53 …

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Superior Cerebellar Artery Territory Infarction

Lynn K. Struck, José Biller, Askiel Bruno, Richard F. Neiman et autres

We prospectively reviewed the clinical and neuroimaging features of 10 men and 7 women (aged 25-81) with recent superior cerebellar artery territory infarctions. Six patients had superior cerebellar artery infarctions restricted to one cerebellar hemisphere. The remaining patients had infarctions in more …

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Erratum

Henry J.M. Barnett, Lynn K. Struck, José Biller, Askiel Bruno et autres

Reliability of Scandinavian Neurological Stroke Scale 107 facial palsy and partly by the differences in the process of calculating simple and weighted kappa. Further im provement of reliability can be obtained by more precise definition of the rating criteria. Another measure of …