W. Guan

[Call for attention on evaluation of bone quality based on three-dimensional interconnected bone trabecular network in radiology].

Ping Zhang, Jing Li, W. Guan, Siyao “Violet” Li et autres

Bone trabeculae are key components of bone microstructure, and their complex three-dimensional interconnected microarchitecture is closely related to bone mechanical properties. Traditional imaging studies have been mostly limited to two-dimensional morphological analysis of bone trabeculae, with insufficient attention paid to their interconnected …

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Spatialomic Analysis of Kidney Biopsies Identifies Differential Abundance of Transcripts and Cell Types by Glomerular and Non-Glomerular Regions Associated with Kidney Allograft Loss

Guillaume C. Onyeaghala, Z. Rao, JP Grande, W. Guan et autres

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[The impact of different bariatric metabolic surgery on bone marrow fat in patients with metabolic syndrome].

Tongyan Zhang, W. Guan, Mingxuan Li, Jia Liu et autres

BMFF in patients with metabolic syndrome decreases after bariatric and metabolic surgery. BMFF changes are similar after different surgical methods, and positively correlated with body weight and BMI changes.

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Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles

William S. Oetting, David P. Schladt, W. Guan, Michael B. Miller et autres

We previously reported that tacrolimus (TAC) trough blood concentrations for African American (AA) kidney allograft recipients were lower than those observed in white patients. Subtherapeutic TAC troughs may be associated with acute rejection (AR) and AR-associated allograft failure. This variation in TAC …

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Multi-Gene Pharmacogenomics of Tacrolimus Troughs in Kidney Transplant Recipients.

Rebecca Pulk, David P. Schladt, W. Guan, William S. Oetting et autres

Purpose: Recent studies have proposed a link between 3 genetic markers and tacrolimus troughs and dose. The purpose of this study was to reexamine these associations of POR*28 and CYP3A4*22 variants and ABCC2 haplotypes with tacrolimus trough in a large, ethnically diverse …

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Lower Calcineurin Inhibitor Doses in Older Compared to Younger Kidney Transplant Recipients Yield Similar Troughs

Pamala A. Jacobson, David Schladt, William S. Oetting, Robert Leduc et autres

The number of older adults undergoing kidney transplantation has increased, yet little is known about calcineurin inhibitor (CNI) metabolism in this group. We studied CNI troughs and doses to determine if there were age-related differences in metabolism and dose requirements. We studied …

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Reply to “Genetic Determinants of Mycophenolate-Related Anemia and Leukopenia After Transplantation”

Pamala A. Jacobson, David Schladt, William S. Oetting, Robert Leduc et autres

We thank you for inviting our reply to a letter written by Bouamar et al. related to our recent publication. Their analysis of the genetic substudy of the clinical trial comparing fixed-dose mycophenolate mofetil treatment with concentration-controlled treatment (FDCC) supported our findings …

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Genetic and Clinical Determinants of Early, Acute Calcineurin Inhibitor-Related Nephrotoxicity

Pamala A. Jacobson, David Schladt, Ajay K. Israni, William S. Oetting et autres

BACKGROUND: Calcineurin inhibitor (CNI)-related acute nephrotoxicity is a common complication of transplantation. Clinical factors and elevated CNI levels are associated with nephrotoxicity; however, they do not fully explain the risk. Genetic factors may also predispose individuals to nephrotoxicity. METHODS: We enrolled 945 …

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Novel Polymorphisms Associated With Tacrolimus Trough Concentrations: Results From a Multicenter Kidney Transplant Consortium

Pamala A. Jacobson, William S. Oetting, Ann M. Brearley, Robert Leduc et autres

BACKGROUND: The CYP4503A5*1 genotype is associated with lower tacrolimus concentrations. Although its effect is important, it incompletely explains the variability in tacrolimus concentrations and has a relatively low minor allele frequency in whites relative to African Americans (AA). METHODS: We studied clinical …

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Genetic Determinants of Mycophenolate-Related Anemia and Leukopenia After Transplantation

Pamala A. Jacobson, David Schladt, William S. Oetting, Robert Leduc et autres

BACKGROUND: Mycophenolate-related anemia and leukopenia are well-known toxicities after transplantation. Toxicity leads to dose reduction, addition of colony-stimulating factors or erythropoietin, or discontinuation of immunosuppressive therapy. The causes of and risk factors associated with toxicity are unclear. METHODS: We studied the association …

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SINGLE NUCLEOTIDE POLYMORPHISM ASSOCIATED WITH SEVERITY OF ACUTE REJECTION ON KIDNEY ALLOGRAFT BIOPSIES

Ajay K. Israni, Robert Leduc, Pamala A. Jacobson, David Schladt et autres

Israni, A.; Leduc, R.; Jacobson, P.; Schladt, D.; Guan, W.; Oetting, W.; Matas, A. For DeKAF Investigators Author Information

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PANAX NOTOGINSENG SAPONINS INDUCED OF HUMAN RENAL INTERSTITIAL FIBROBLAST AND ITS MECHANISMS

G Q Zhang, Renping Ye, Qing-Hua Kong, Ningning Yang et autres