Lower Calcineurin Inhibitor Doses in Older Compared to Younger Kidney Transplant Recipients Yield Similar Troughs
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The number of older adults undergoing kidney transplantation has increased, yet little is known about calcineurin inhibitor (CNI) metabolism in this group. We studied CNI troughs and doses to determine if there were age-related differences in metabolism and dose requirements. We studied 348 young (18-34 years), 1831 middle (35-64 years) and 374 older (65-84 years) adult kidney transplant recipients enrolled in a seven-center prospective study. Troughs were obtained from each patient 2×/week in weeks 1-8 and 2×/month in months 3-6. A multivariable linear-mixed model examined the effect of age on log dose and weight normalized troughs. Older recipients had higher normalized tacrolimus troughs than middle or young age adults despite receiving doses a median of 1-2 mg/day lower. Age and CYP3A5*1 genotype had the largest effect on tacrolimus troughs. Older recipients also had higher normalized cyclosporine troughs than middle or young adults despite receiving median doses 100 mg/day lower. After normalization for dose and weight, CNI troughs were more than 50% higher in older adults than young adults. These data support age-related changes in CNI metabolism. Further studies are needed to determine optimal dosing of CNIs in the elderly.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Lower Calcineurin Inhibitor Doses in Older Compared to Younger Kidney Transplant Recipients Yield Similar Troughs
- Date Crossref
- 01/12/2012
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
University of Minnesota Department of Experimental and Clinical Pharmacology pays non établi dans la noticeUniversité ou école supérieure
-
Cancer Research And Biostatistics pays non établi dans la noticeOrganisation à but non lucratif
-
University of Minnesota System pays non établi dans la noticeUniversité ou école supérieure
-
Hennepin County Medical Center Department of Medicine pays non établi dans la noticeÉtablissement de santé
-
Division of Biostatistics pays non établi dans la noticeInstitution
-
Institute of Human Genetics pays non établi dans la noticeStructure de recherche
-
Dept of Surgery pays non établi dans la noticeInstitution
Department of Experimental and Clinical Pharmacology — University of Minnesota, Cancer Research And Biostatistics et University of Minnesota System, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.