Agnès Beby‐Defaux

A French national observatory of people with HIV initiating lenacapavir-based treatment after regulatory approval

Charlotte Charpentier, Thomas Montrouge, Marc Wirden, Véronique Avettand-Fenoel et autres

ABSTRACT There is limited data on lenacapavir (LEN) use, the newest capsid inhibitor, in observational settings. We describe population characteristics and pharmaco-virological outcomes of people with HIV-1 (PWH) who initiated LEN-based treatment. We conducted a national retrospective observational study of PWH initiating …

fr (code pays fourni par la source)

Systematic three-site vs. classical single-site screening for Chlamydia trachomatis and Neisseria gonorrhoeae infections in non-sex worker women: the multicentric Sexually Infections Still Transmitted by Remote Sites (SIST’RS) study

T. Prazuck, Gwenael L.E. MOAL, Axel Ursenbach, Christophe Michau et autres

OBJECTIVES: Guidelines recommend extragenital screening for sexually transmitted infections in men having sex with men but not for women who do not report extravaginal intercourses. However, it has been suggested that among female commercial sex workers, limiting sexually transmitted infection screening to …

fr (code pays fourni par la source)

Pooling Rectal, Pharyngeal, and Urine Samples to Detect Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium Using Multiplex Polymerase Chain Reaction Is as Effective as Single-Site Testing for Men Who Have Sex With Men

Thiérry Prazuck, Philippe Lanotte, Gwenael Le Moal, Laurent Hocqueloux et autres

Abstract Background Screening for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) at pharyngeal, urogenital, and anorectal sites is recommended for men who have sex with men (MSM). Pooling samples is a promising technique, but no data are available when pooled screening also …

fr (code pays fourni par la source)

Multiplex PCR assay targeting Trichomonas vaginalis: need for biological evaluation and interpretation

Adélaïde Chesnay, Adeline Pastuszka, Lucie Richard, Agnès Beby‐Defaux et autres

fr (code pays fourni par la source)

High levels of HPV16-L1 antibody but not HPV16 DNA load or integration predict oropharyngeal patient outcome: The Papillophar study

Jean‐Luc Prétet, Véronique Dalstein, Antoine Touzé, Agnès Beby‐Defaux et autres

fr (code pays fourni par la source)

Emergence of the SARS‐CoV‐2 B.1.1.7 variant observed at the Poitiers University Hospital

Florent Hubert, Céline Chessa, Agnès Beby‐Defaux, Anne Bourgoin et autres

International audience

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Characterization of a new case of XMLV (Bxv1) contamination in the human cell line Hep2 (clone 2B)

Vincent Loiseau, Richard Cordaux, Isabelle Giraud, Agnès Beby‐Defaux et autres

The use of misidentified cell lines contaminated by other cell lines and/or microorganisms has generated much confusion in the scientific literature. Detailed characterization of such contaminations is therefore crucial to avoid misinterpretation and ensure robustness and reproducibility of research. Here we use …

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Stable prevalence of transmitted drug resistance mutations and increased circulation of non-B subtypes in antiretroviral-naive chronically HIV-infected patients in 2015/2016 in France

Lambert Assoumou, Laurence Bocket, Coralie Pallier, Maxime Grudé et autres

OBJECTIVES: We estimated the prevalence of transmitted-drug-resistance-associated mutations (TDRAMs) in antiretroviral-naive chronically HIV-1-infected patients. PATIENTS AND METHODS: TDRAMs were sought in samples from 660 diagnosed HIV-1-infected individuals in 2015/2016 in 33 HIV clinical centres. Weighted analyses, considering the number of patients followed …

fr, mq (code pays fourni par la source)

Emerging resistance mutations in PI-naive patients failing an atazanavir-based regimen (ANRS multicentre observational study)

Sidonie Lambert-Niclot, Maxime Grudé, Marie‐Laure Chaix, Charlotte Charpentier et autres

Background: Atazanavir is a PI widely used as a third agent in combination ART. We aimed to determine the prevalence and the patterns of resistance in PI-naive patients failing on an atazanavir-based regimen. Methods: We analysed patients failing on an atazanavir-containing regimen …

fr, nc (code pays fourni par la source)

Detection of the Merkel cell polyomavirus in the neuroendocrine component of combined Merkel cell carcinoma

Thibault Kervarrec, Mahtab Samimi, Pauline Gaboriaud, Tarik Gheit et autres

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin. The main etiological agent is Merkel cell polyomavirus (MCPyV), detected in 80% of cases. About 5% of cases, called combined MCC, feature an admixture of neuroendocrine and non-neuroendocrine tumor cells. …

fr, ch, de (code pays fourni par la source)

Predictive factors of spontaneous CMV DNAemia clearance in kidney transplantation

Johan Noble, Philippe Gatault, Bénédicte Sautenet, Catherine Gaudy‐Graffin et autres

fr (code pays fourni par la source)

Impact of Human Immunodeficiency Virus Type 1 Minority Variants on the Virus Response to a Rilpivirine-Based First-line Regimen

Stéphanie Raymond, Florence Nicot, Coralie Pallier, Pantxika Bellecave et autres

Background: Minority resistant variants of human immunodeficiency virus type 1 (HIV-1) could influence the virological response to treatment based on nonnucleoside reverse transcriptase inhibitors (NNRTIs). Data on minority rilpivirine-resistant variants are scarce. This study used next-generation sequencing (NGS) to identify patients harboring …

fr, Mali (code pays fourni par la source)