Ruth D. Allen

A Journey through Scaffolds: Indolines, Pyrrolidines, and Azetidines in the Quest for Inhaled DDR Inhibitors for IPF

Laura Carzaniga, Fabio Rancati, A. Rizzi, Roberta Mazzucato et autres

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease, with excessive Extracellular Matrix (ECM) deposition impairing gas exchange, leading to lung failure. Current treatments are limited, with lung transplantation as the only cure. Discoidin Domain Receptors (DDR1/2), collagen-activated receptor tyrosine kinases, orchestrate …

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Surgical pathology of subaortic septal myectomy associated with hypertrophic cardiomyopathy A study of 229 cases

G. T. Lamke, Ruth D. Allen, W. D. Edwards, Henry D. Tazelaar et autres

A Locus Closely Linked to Mtv7 on Mouse Chromosome 1 Influences Development of Acute versus Chronic Graft-versus-Host Disease in a Murine Model

Ruth D. Allen, Denise L. Slayback, Jill M. Harper, Terra L. Aguirre et autres

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Polymorphism of the human TNF-α promoter — random variation or functional diversity?

Ruth D. Allen

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Differential cytokine expression in acute and chronic murine graft‐versus‐host‐disease

Ruth D. Allen, Tabitha A. Staley, Charles L. Sidman

The relationship between acute and chronic graft-versus-host disease (GVHD) is not well understood. While both syndromes appear to result from recognition of host antigens by donor T cells, their pathological changes differ markedly. In light of the recent concept that helper T …

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Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

Marcia M. Shull, Ilona Ormsby, Ann B. Kier, Sharon A. Pawlowski et autres

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Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules.

Ruth D. Allen, Jan D. Marshall, John B. Roths, Charles L. Sidman

Homozygosity for either of the lymphoproliferation (lpr) or generalized lymphoproliferative disease (gld) mutations of mice causes the development of systemic lupus erythematosus-like autoimmune syndromes that are characterized by severe lymphadenopathy and highly elevated serum immunoglobulin levels. Although the mutations are nonallelic, analysis …

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IMMUNODEFICIENCY AFTER TRANSPLANTATION OF ALLOANTIGEN-MATCHED BONE MARROW FROM AN IMMUNOREGULATORY MUTANT

Ruth D. Allen, Jan D. Marshall, John B. Roths

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Bone marrow transplantation from mutant lpr/lpr mice. Functional abnormalities rather than alloantigenic differences appear to determine the development of a graft‐vs. ‐host‐like syndrome

Ruth D. Allen, Jan D. Marshall, John B. Roths, Charles L. Sidman

Transfer of bone marrow (BM) from autoimmunity-prone mice homozygous for the lymphoproliferation (lpr) mutation to irradiated congenic +/+ recipients has previously been shown to result in a syndrome similar to chronic graft-vs.-host (GVH) disease. It has been suggested that this syndrome may …

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Spontaneous Pneumocystis carinii pneumonia in immunodeficient mutant scid mice. Natural history and pathobiology.

John B. Roths, Jan D. Marshall, Ruth D. Allen, George A. Carlson et autres

The opportunistic pathogen Pneumocystis carinii (Pc) poses a major clinical health problem in individuals with immune deficiency, including those patients with human immunodeficiency (HIV)-associated acquired immune deficiency disease (AIDS). Heretofore, in vivo investigations of the biology of Pc and pathogenesis of pneumocystosis …

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Murine "viable motheaten" mutation reveals a gene critical to the development of both B and T lymphocytes.

Charles L. Sidman, Jan D. Marshall, Ruth D. Allen

In lethally irradiated normal mice reconstituted with both normal and autoimmune mutant viable motheaten (mev) bone marrow, the mev-derived B and T cells display aberrant behavior, while those derived from the normal bone marrow develop and function normally. The observed developmental abnormalities …

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