Bernard Higgins

OWE-001 Acetic acid guided biopsies versus mapping biopsies for barrett’s surveillance: the ABBA study

Gaius Longcroft‐Wheaton, Carole Fogg, John S De Caestecker, Hugh Barr et autres

Introduction Barrett’s surveillance traditionally requires mapping biopsies to identify neoplasia. Acetic acid (AA) allows only targeted biopsies, potentially reducing the number of biopsies required. This study aims to compare neoplasia detection with AA targeted biopsies and protocol guided non-targeted biopsies during Barrett’s …

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Acetic acid-guided biopsies in Barrett’s surveillance for neoplasia detection versus non-targeted biopsies (Seattle protocol): A feasibility study for a randomized tandem endoscopy trial. The ABBA study

Fergus Chedgy, Carole Fogg, Kesavan Kandiah, Hugh Barr et autres

BACKGROUND AND STUDY AIMS: Barrett's esophagus is a potentially pre-cancerous condition, affecting 375,000 people in the UK. Patients receive a 2-yearly endoscopy to detect cancerous changes, as early detection and treatment results in better outcomes. Current treatment requires random mapping biopsies along …

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Endocuff-assisted vs. standard colonoscopy in the fecal occult blood test-based UK Bowel Cancer Screening Programme (E-cap study): a randomized trial

Rupam Bhattacharyya, Fergus Chedgy, Kesavan Kandiah, Carole Fogg et autres

Abstract Background and study aims Up to 25 % colorectal adenomas are missed during colonoscopy. The aim of this study was to investigate whether the endocuff could improve polyp detection in an organized bowel cancer screening program (BCSP). Patients and methods This …

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High‐definition vs. standard‐definition endoscopy with indigo carmine for the in vivo diagnosis of colonic polyps

Gaius Longcroft‐Wheaton, J F Brown, David Cowlishaw, Bernard Higgins et autres

BACKGROUND: There is growing evidence that indigo carmine chromoendoscopy is effective for the in vivo diagnosis of colonic polyps. However, the impact of colonoscope resolution on diagnostic accuracy has not been investigated. OBJECTIVE: We aimed to compare the effectiveness of in vivo …

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Flexible spectral imaging color enhancement and indigo carmine in neoplasia diagnosis during colonoscopy

Gaius Longcroft‐Wheaton, Bernard Higgins, Pradeep Bhandari

OBJECTIVES: At present, all colonic polyps are removed and sent for histopathological evaluation, resulting in laboratory and reporting costs. Recent American Society for Gastrointestinal Endoscopy (ASGE) guidelines have set standards for in-vivo diagnosis in place of conventional histopathology, and all future technologies …

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A correlation of time with meniscal tears in anterior cruciate ligament deficiency: stratifying the risk of surgical delay

Edward R. Tayton, Rajeev Kumar Verma, Bernard Higgins, Harminder S. Gosal

Two hundred and five patients with ACL rupture, who had been diagnosed pre-operatively by either MRI scan or knee arthroscopy, had reconstructions between 2003 and 2007. The diagnostic meniscal findings were compared with those at reconstruction, and any further damage along with …

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Pharmacological management of hypertension

Bernard Higgins, Bryan Williams, Lynne Turner‐Stokes

Hypertension is a major risk factor for cardiovascular disease, and is both common and amenable to treatment. Several major new studies have appeared recently and in response the National Institute for Health and Clinical Excellence and the British Hypertension Society have collaborated …

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Promoter Dependence of Plasmid–Pluronics Targeted α Galactosidase A Expression in Skeletal Muscle of Fabry Mice

Matthieu David Lavigne, Marita Pohlschmidt, Bernard Higgins, Valery Yu. Alakhov et autres

Anderson–Fabry disease is an X-linked lysosomal storage disorder (LSD) caused by α-galactosidase A (AGA) deficiency [1]. There is evidence that LSDs could be corrected by gene transfer and expression and enzyme secretion from a subset of cells or a specific tissue [2–4]. …

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Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma

Sanjay Sharma, Michael H. Neale, Federica Di Nicolantonio, Louise A. Knight et autres

BACKGROUND: We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared with that of a similar assay used in a different country in …

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A randomized trial of winged Vialon cannulae and metal butterfly needles

Linda Dawkins, Doreen Britton, Ian M. Johnson, Bernard Higgins et autres

The purpose of this parallel randomized study was to evaluate whether subcutaneous infusion sites initiated with winged vialon cannulae would have fewer skin reactions and longer site duration than metal butterfly needles and reduce needlestick injuries to staff. Data were collected on …

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Conservative treatment of anorectal tumors

Josef Paul Kovarik, Vladimir H. J. Svoboda, Bernard Higgins

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Conservative treatment of anorectal tumors

Josef Paul Kovarik, Vladimir H. J. Svoboda, Bernard Higgins

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