Terry Cook

GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Peter Dixon, Adam P. Levine, Inês Cebola, Melanie Chan et autres

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting 0.5-2% of pregnancies. The majority of cases present in the third trimester with pruritus, elevated serum bile acids and abnormal serum liver tests. ICP is associated with an increased risk of …

gb, cn, Soudan du Sud, nl, sg, it, au, ar, fr, be (code pays fourni par la source)

POS-048 PHASE 3, RANDOMIZED, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PEGCETACOPLAN IN TREATMENT OF C3G OR IC-MPGN

Giuseppe Remuzzi, Bradley P. Dixon, Fádi Fakhouri, Matthew C. Pickering et autres

Complement 3 glomerulopathy (C3G) and immune complex membranoproliferative glomerulonephritis (IC-MPGN) are rare diseases characterized by excessive deposition of C3 breakdown products in renal glomeruli leading to proteinuria and progressive renal disease. Pegcetacoplan is a targeted C3 investigational therapy for diseases related to …

it, us, ch, gb, ca (code pays fourni par la source)

Application of direct stochastic optical reconstruction microscopy ( dSTORM ) to the histological analysis of human glomerular disease

Edwin García, Jonathan Lightley, Sunil Kumar, Ranjan Kalita et autres

Electron microscopy (EM) following immunofluorescence (IF) imaging is a vital tool for the diagnosis of human glomerular diseases, but the implementation of EM is limited to specialised institutions and it is not available in many countries. Recent progress in fluorescence microscopy now …

gb (code pays fourni par la source)

MO126CLINICAL AND BIOMARKER CHARACTERISTICS OF PATIENTS WITH C3G OR IC-MPGN ENROLLED IN TWO PHASE II STUDIES INVESTIGATING THE FACTOR D INHIBITOR DANICOPAN*

Carla Nester, Steven D. Podos, Jonathan Hogan, Gerald B. Appel et autres

Abstract Background and Aims C3 glomerulopathy (C3G) and immune complex membranoproliferative glomerulonephritis (IC-MPGN) are rare, progressive kidney diseases requiring a biopsy for definite diagnosis. Both C3G and IC-MPGN are attributed to complement dysregulation, with dysregulation of the alternative pathway established in C3G …

us, be, gb, it, nl (code pays fourni par la source)

Technical considerations when designing a gene expression panel for renal transplant diagnosis

Frédéric Toulza, Kathy Dominy, Terry Cook, Jack Galliford et autres

Gene expression analysis is emerging as a new diagnostic tool in transplant pathology, in particular for the diagnosis of antibody-mediated rejection. Diagnostic gene expression panels are defined on the basis of their pathophysiological relevance, but also need to be tested for their …

gb (code pays fourni par la source)

Anti–glomerular basement membrane disease during the COVID-19 pandemic

Maria Prendecki, Candice Clarke, Tom Cairns, Terry Cook et autres

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P0357VALIDATION OF THE ANCA RENAL RISK SCORE IN A LONDON COHORT: POTENTIAL IMPACT OF TREATMENT ON PREDICTION OUTCOME

Pek Ghe Tan, Jennifer OʼBrien, Megan Griffith, Marie Condon et autres

Abstract Background and Aims A renal risk score was recently developed to predict the risk of progression to end stage kidney disease (ESKD) in patients with ANCA-associated glomerulonephritis (ANCA-GN). The score defines three risk groups, each with distinct renal survival at 36 …

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OP0044 WHOLE KIDNEY TRANSCRIPTOMIC ANALYSIS OF FORMALIN-FIXED PARAFFIN-EMBEDDED LUPUS NEPHRITIS KIDNEY BIOPSY TISSUE USING THE NANOSTRING NCOUNTER PLATFORM

Alyssa Gilmore, Hannah R. Wilson, Tom Cairns, Marina Botto et autres

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Improving treatment decisions using personalized risk assessment from the International IgA Nephropathy Prediction Tool

Sean J. Barbour, Mark Canney, Rosanna Coppo, Hong Zhang et autres

ca, it, cn, jp, gb (code pays fourni par la source)

Electron microscopic investigations in COVID-19: not all crowns are coronas

Candice Roufosse, Elizabeth Curtis, Linda Moran, Michael Hollinshead et autres

gb (code pays fourni par la source)

OR48 Gene expression analysis in renal transplant biopsies: Comparison of split samples and different techniques

Frédéric Toulza, Kathy Dominy, Jack Galliford, Terry Cook et autres

gb (code pays fourni par la source)

Analysis of HLA-G expression in renal tissue in lupus nephritis: a pilot study

Valentina Foschi, Daria Bortolotti, Anne Frances Doyle, Victoria Stratigou et autres

BACKGROUND: The study aimed to investigate whether HLA-G antigen is expressed in the kidneys of patients affected by lupus nephritis (LN) and whether its detection in renal biopsies could be adopted as a marker of treatment response and prognosis. METHODS: Thirty renal …

it, gb (code pays fourni par la source)