Li Fu

Development and validation of a motivation scale for deep vein thrombosis prophylaxis in postdischarge hip and knee arthroplasty patients

Feng Fu, Xiurui Deng, Wenchao Gu, Leijiang Li et autres

This study developed the Deep Vein Thrombosis Prophylaxis Motivation Scale (DVT-PMS) grounded in Protection Motivation Theory and evaluated its psychometric properties in post-arthroplasty patients. Using a sequential mixed-methods design, items were generated from literature review, semi-structured interviews, and expert panel consultation, then …

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Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics

Xiao Ma, Tengda Huang, Xi Chen, Qian Li et autres

Liver repair and regeneration are crucial physiological responses to hepatic injury and are orchestrated through intricate cellular and molecular networks. This review systematically delineates advancements in the field, emphasizing the essential roles played by diverse liver cell types. Their coordinated actions, supported …

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Glycemic Oscillation Decomposition-Based Personalized Blood Glucose Prediction with Continuous Glucose Monitoring

Li Fu, Yongjun Li, Jia Sun

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MTGlu: A Multi-scale Time-Frequency Approach for Personalized Glucose Prediction in Type 1 Diabetes

Li Fu, Ying Li, Xuxue Sun, Yuxin Wen et autres

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Chidamide triggers pyroptosis in T-cell lymphoblastic lymphoma/leukemia via the FOXO1/GSDME axis

Xinlei Li, Bangdong Liu, Dezhi Huang, Naya Ma et autres

BACKGROUND: T-cell lymphoblastic lymphoma/acute lymphoblastic leukemia (T-LBL/ALL) is an aggressive form of hematological malignancy associated with poor prognosis in adult patients. Histone deacetylases (HDACs) are aberrantly expressed in T-LBL/ALL and are considered potential therapeutic targets. Here, we investigated the antitumor effect of …

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Lithium Promotes Osteogenesis via Rab11a-Facilitated Exosomal Wnt10a Secretion and β-Catenin Signaling Activation

Changjun Chen, Baoning Wang, Xin Zhao, Yue Luo et autres

Both bone mesenchymal stem cells (BMSCs) and their exosomes suggest promising therapeutic tools for bone regeneration. Lithium has been reported to regulate BMSC function and engineer exosomes to improve bone regeneration in patients with glucocorticoid-induced osteonecrosis of the femoral head. However, the …

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Identification of pyroptosis-related gene signature in nonalcoholic steatohepatitis

Fei Mao, E. Wang, Li Fu, Wenhua Fan et autres

Non-alcoholic fatty liver disease (NAFLD) has emerged as one of the major causes of liver-related morbidity and mortality globally. It ranges from simple steatosis to non-alcoholic steatohepatitis (NASH) characterized by ballooning and hepatic inflammation. In the past few years, pyroptosis has been …

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Effects of long-term exposure to ambient fine particulate matter and its specific components on blood pressure and hypertension incidence

Li Fu, Yanfei Guo, Qijiong Zhu, Zhiqing Chen et autres

Epidemiological evidence on the association of PM2.5 (particulate matter with aerodynamic diameter ≤ 2.5 μm) and its specific components with hypertension and blood pressure is limited. We applied information of participants from the World Health Organization's (WHO) Study on Global Ageing and …

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Epididymal RNase T2 contributes to astheno-teratozoospermia and intergenerational metabolic disorder through epididymosome-sperm interaction

Zhuoyao Ma, Jinyu Li, Li Fu, Rong Fu et autres

BACKGROUND: The epididymis is crucial for post-testicular sperm development which is termed sperm maturation. During this process, fertilizing ability is acquired through the epididymis-sperm communication via exchange of protein and small non-coding RNAs (sncRNAs). More importantly, epididymal-derived exosomes secreted by the epididymal …

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Apabetalone Reduces Fibrotic Inflammatory and Calcific Factors in Renal Cells and Patient Plasma

Dean Gilham, Sylwia Wasiak, Brooke D. Rakai, Li Fu et autres

Background: The BET protein inhibitor apabetalone downregulates the expression of genes involved in fibrosis, inflammation and calcification, processes that drive cardiovascular disease and kidney dysfunction. In the phase 3 BETonMACE trial, apabetalone reduced the risk of major acute cardiac event (MACE) by …

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Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells

Christopher D. Sarsons, Dean Gilham, Laura Tsujikawa, Sylwia Wasiak et autres

expression have the potential to treat FSHD. Apabetalone is a clinical-stage bromodomain and extra-terminal (BET) inhibitor, selective for the second bromodomain on BET proteins. Using primary human skeletal muscle cells from FSHD type 1 patients, we evaluated apabetalone for its ability to …

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P1191: A NOVEL PROGNOSTIC MODEL OF DLBCL PATIENTS BASED ON CUPROPTOSIS RELATED GENES

Li Fu, LI Jia-li, Jun Rao, Shijia Lin et autres

Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical Background: The current classification system for diffuse large B-cell lymphoma (DLBCL) cannot fully explain the prognostic differences of DLBCL patients. Cuproptosis is a newly discovered programmed cell death which depend on copper ions. However, the …

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