Jun Rao

Efficacy and safety of the single-dose pegylated G-CSF vs. daily G-CSF for peripheral blood stem cells mobilization in donors: a multicenter, randomized controlled trial

Jiali Li, Zhou Sha, Xiaoping Li, Xiangyu Ma et autres

Background The mobilization of peripheral blood stem cells(PBSC) needs daily injection of granulocyte colony stimulating factor (G-CSF), which brings inconvenience to healthy donors. Can pegylated granulocyte colony-stimulating factor (Peg-G-CSF) solve this problem by single dose injection? Methods This multicenter, randomized controlled study …

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Mitoxantrone liposome combined with EAC autologous transplant conditioning for the treatment of T/NK non-Hodgkin's lymphoma

Jiali Li, Dezhi Huang, Jun Rao, Song Dong et autres

Abstract Objectives: New drug combination therapy can improve the survival rate of patients with T-cell lymphoma, but autologous hematopoietic stem cell transplantation (HSCT) is still indispensable. There is currently no standard pretreatment protocol for Auto-HSCT. Existing conditioning regimens have limited efficacy, with …

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Combining next-generation sequencing and optical genome mapping techniques to analyze genomic abnormalities in marginal zone lymphoma

Xixi Xiang, Bo Liu, Yang Hanshan, Jiali Li et autres

Abstract Introduction Optical genome mapping (OGM) is a novel DNA-based technology enabling comprehensive genome-wide analysis of cytogenomic aberrations, including alterations frequently missed by conventional cytogenetics. Next-generation sequencing (NGS) provides comprehensive mutational profiling at the nucleotide level, detecting point mutations, insertions, deletions, and …

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Ultrasensitive detection of tsRNA through a transcleavage cross-linking Cas13-Cas14a tool

Gaihua Cao, Qin Liu, Wei Xu, Jun Rao et autres

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Identification of Copy Number Alterations From Shallow Whole‐Genome Sequencing in Multiple Myeloma

Jiali Li, Shaobing Gao, Zhenling Li, Yuexin Cheng et autres

Multiple myeloma (MM) is a malignant neoplasm of plasma cells leading to bone destruction and marrow failure. Prognosis and management of MM rely on cytogenetic determination of copy number alterations (CNAs). Nevertheless, karyotype analysis difficult due to the presence of few plasma …

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Association between gut microbiota and lymphomas: A bidirectional multivariable Mendelian randomization study

Jingkang Xiong, Chaokun Hong, Su Ge, Lijuan Liu et autres

To the Editor: Lymphomas, classified as hematological malignancies (HMs),[1,2] continue to pose significant challenges to public health. Although gut microbiota is widely connected with lymphoma via several plausible mechanisms,[1–4] the causality and directionality of this relationship are not fully understood. Therefore, a …

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Clinical Scale Cryopreservation of Human Deceased Donor Islet and Stem Cell-Derived Beta Clusters by Vitrification for Allotransplantation in Type I Diabetes

Jun Rao, Zhendong Guo, Zenith Khashim, Pundi Narasimhan Rangarajan et autres

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756 | REAL‐WORLD STUDY OF GOLIDOCITINIB FOR THE TREATMENT OF RELAPSED OR REFRACTORY PERIPHERAL T CELL LYMPHOMA: RETROSPECTIVE DATA FROM MEDICAL CENTERS IN CHINA

He Huang, Yan Wei Gao, Guifang Ouyang, Li Liu et autres

Introduction: Diagnosing T-cell lymphoma (T-NHL) is often challenging due to phenotypic overlap with reactive T-cells.Antibodies targeting the two mutually exclusive isoforms of the constant TCR β-chain, TRBC1 and TRBC2, provide a unique opportunity to assess clonality, given that reactive T cells exhibit …

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A 6-tsRNA signature for early detection, treatment response monitoring, and prognosis prediction in diffuse large B cell lymphoma

Jun Rao, Xia Lin, Qiong Li, Naya Ma et autres

Diffuse large B-cell lymphoma (DLBCL) presents considerable clinical challenges due to its aggressive nature and diverse clinical progression. New molecular biomarkers are urgently needed for outcome prediction. We analyzed blood samples from DLBCL patients and healthy individuals using short, non-coding RNA sequencing. …

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125TiP Prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) for locally advanced colorectal cancer: A single-centre, open-label, randomized controlled trial

Shuaimei Xu, Z. Chen, Zuowei Wang, Jun Rao et autres

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Preliminary Efficacy of Orelabrutinib Targeted Therapy in Induction Therapy of Primary Central Nervous System Diffuse B-Cell Lymphoma

Sha Zhou, Jun Rao, Xixi Xiang, Yunjing Zeng et autres

Objective: To evaluate the efficacy and safety of the induction regimen of targeted therapy of Orelabrutinib combined with chemotherapy in primary central nervous system diffuse B-cell lymphoma. Methods: Patients aged 18 years and above with primary central nervous system diffuse B-cell lymphoma …

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Preliminary Results of a Retrospective Study on a Regimen Based on Orelabrutinib Combined with Anti-CD20 Monoclonal Antibody in Patients with Marginal Zone Lymphoma

Hongling Peng, Xixi Xiang, Jun Rao, Wenzhe Yan et autres

Background: Marginal zone lymphoma (MZL) is the second most prevalent form of indolent lymphoma and the optimal strategy for symptomatic, advanced MZL is CD20-based monoclonal therapy. Orelabrutinib, a novel and irreversible Bruton's tyrosine kinase (BTK) inhibitor, exhibited a high overall response rate …

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