Ju Jia

Factors associated with recompensation and criteria for etiological suppression in patients with primary biliary cholangitis

Shen Li, Tingting Lv, Shuxiang Li, Sha Chen et autres

cn (code pays fourni par la source)

Monocyte-derived macrophages support alveolar regeneration via oncostatin M post-H1N1 infection during the recovery phase

Xiao Shang, Ju Jia, Jiapei Yu, Shumei Zou et autres

BACKGROUND: Severe influenza virus infection often triggers acute lung injury, and the efficacy of respiratory functional recovery critically depends on timely alveolar regeneration. However, the cellular dynamics and regulatory mechanisms underlying post-infectious alveolar repair remain incompletely understood. METHODS: Utilizing Sftpc-CreER; Rosa26-mTmG lineage-tracing …

cn (code pays fourni par la source)

Time-resolved scRNA-seq reveals transcription dynamics of polarized macrophages with influenza A virus infection and antigen presentation to T cells

Jiapei Yu, Congcong Shang, Xiaoyan Deng, Ju Jia et autres

Throughout history, the influenza A virus has caused numerous devastating global pandemics. Macrophages, as pivotal innate immune cells, exhibit a wide range of immune functions characterized by distinct polarization states, reflecting their intricate heterogeneity. In this study, we employed the time-resolved single-cell …

cn (code pays fourni par la source)

Comprehensive immune landscape of lung-resident memory CD8+ T cells after influenza infection and reinfection in a mouse model

Ju Jia, Hui Li, Zhisheng Huang, Jiapei Yu et autres

Background Resident phenotypic memory CD8+ T cells are crucial for immune defense against pathogens. However, little is known about the potential transitions and regulation mechanisms of their function after influenza virus infection and reinfection. In this study, we utilized integrated transcriptome data …

cn (code pays fourni par la source)

Cycling and activated CD8+ T lymphocytes and their association with disease severity in influenza patients

Shuai Liu, Zhisheng Huang, Ruyue Fan, Ju Jia et autres

Abstract Background T cell lymphopenia was a significant characteristic of severe influenza infection and it was associated with the functional changes of T cells. It is necessary to clarify the T cells characteristics of kinetic changes and their correlation with disease severity. …

cn (code pays fourni par la source)

[The 494th case: acute pancreatitis, acute acalculous cholecystitis and anaphylaxis].

Zhouxian Pan, L L Wang, Le Cui, J N Li et autres

A young male patient with abdominal pain and fever was diagnosed as acute hyper-triglyceridemicpancreatitis is clear. During the recovery of pancreatitis, the patient developed acute acalculous cholecystitis, as well as carbapenem-resistant Enterobacter infection and Cytomegaloviremia, and had anaphylaxis for several times after …

cn (code pays fourni par la source)

Identification of Neutrophil-Related Factor LCN2 for Predicting Severity of Patients With Influenza A Virus and SARS-CoV-2 Infection

Zhisheng Huang, Hui Li, Shuai Liu, Ju Jia et autres

Background: Influenza and COVID-19 are respiratory infectious diseases that are characterized by high contagiousness and high mutation and pose a serious threat to global health. After Influenza A virus (IAV) and SARS-CoV-2 infection, severe cases may develop into acute lung injury. Immune …

cn (code pays fourni par la source)

Pandemic influenza A (H1N1) virus causes abortive infection of primary human T cells

Jiapei Yu, Hui Li, Ju Jia, Zhisheng Huang et autres

Influenza A virus still represents a noticeable epidemic risk to international public health at present, despite the extensive use of vaccines and anti-viral drugs. In the fight against pathogens, the immune defence lines consisting of diverse lymphocytes are indispensable for humans. However, …

cn, au, us (code pays fourni par la source)