Cristina Napoli

Clinical outcomes of the chemo‐free approach in relapsed/refractory follicular lymphoma: A network meta‐analysis

Daniele Caracciolo, Maria Rita Lombardo, Gianluca Reitano, Cristina Napoli et autres

Summary Relapsed/refractory follicular lymphoma (R/R FL) remains a clinically challenging condition, with progressively declining benefit across consecutive lines of therapy. While anti‐Cluster of Differentiation 20 (CD20) antibodies remain the therapeutic backbone, the optimal targeted or immune‐based partner remains undefined. A systematic review …

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Targeting z-Crystallin by aspirin restores the sensitivity to cisplatin in resistant A2780 ovarian cancer cells

Matteo Lulli, Andrea Trabocchi, Giandomenico Roviello, Martina Catalano et autres

Ovarian cancer is the deadliest gynaecologic malignancies worldwide. Platinum based chemotherapy is the mainstay treatment for ovarian cancer; however, frequent recurrence and chemoresistance onset in patients with advanced diseases remain a therapeutic challenge. Although mechanisms underlying the development of chemoresistance are still …

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Targeting z-Crystallin by aspirin restores the sensitivity to cisplatin in resistant A2780 ovarian cancer cells

Matteo Lulli, Giandomenico Roviello, Martina Catalano, Astrid Parenti et autres

Abstract Purpose Ovarian cancer is the deadliest gynaecologic malignancies worldwide. Platinum based chemotherapy is the mainstay treatment for ovarian cancer; however, frequent recurrence and chemoresistance onset in patients with advanced diseases remain a therapeutic challenge. Although mechanisms underlying the development of chemoresistance …

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The impact of PARP inhibitors in the whole scenario of ovarian cancer management: A systematic review and network meta-analysis

Nicoletta Staropoli, Domenico Ciliberto, Francesco Luciano, Cristina Napoli et autres

BACKGROUND: Carboplatin is still the cornerstone of the first-line treatment in advanced Epithelial Ovarian Cancer (aEOC) management and the clinical response to platinum-derived agents remains the major predictor of long-term outcomes. PATIENT AND METHODS: We aimed to identify the best treatment of …

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First-line systemic treatment for hepatocellular carcinoma: A systematic review and network meta-analysis

Domenico Ciliberto, Giulio Caridà, Nicoletta Staropoli, Caterina Romeo et autres

The rapid development of novel therapeutic options for advanced hepatocellular carcinoma (aHCC) has generated some uncertainty about the rational choice of the systemic upfront treatment. So far, a variety of therapeutic strategies have been investigated, including the combination of immunecheckpoint inhibitors and …

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Role of Non-Coding RNAs in Colorectal Cancer: Focus on Long Non-Coding RNAs

Matteo Lulli, Cristina Napoli, Ida Landini, Enrico Mini et autres

Colorectal cancer is one of the most common causes of cancer-related deaths worldwide. Despite the advances in the knowledge of pathogenetic molecular mechanisms and the implementation of more effective drug treatments in recent years, the overall survival rate of patients remains unsatisfactory. …

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miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review

Maria Teresa Di Martino, Mariamena Arbitrio, Daniele Caracciolo, Alessia Cordua et autres

Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports the potential …

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PNNandKCNQ1OT1Can Predict the Efficacy of Adjuvant Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer Patients

Andrea Lapucci, Gabriele Perrone, Antonello Di Paolo, Cristina Napoli et autres

The benefit of adjuvant chemotherapy in the early stages of colorectal cancer (CRC) is still disappointing and the prediction of treatment outcome quite difficult. Recently, through a transcriptomic approach, we evidenced a role ofPNNandKCNQ1OT1gene expression in predicting response to fluoropyrimidine-based adjuvant chemotherapy …

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Malignant Insulinoma with Multiple Liver Metastases and Hypercalcitoninemia in a Patient with Type 2 Diabetes Mellitus Presenting as Recurrent Episodes of Diaphoresis due to Severe Hypoglycemia

Marco Ciacciarelli, Gianluca Caruso, Marco Rengo, Piero Maceroni et autres

Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally …

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RNA sequencing reveals PNN and KCNQ1OT1 as predictive biomarkers of clinical outcome in stage III colorectal cancer patients treated with adjuvant chemotherapy

Enrico Mini, Andrea Lapucci, Gabriele Perrone, Romina D’Aurizio et autres

Five-year overall survival of stage III colorectal cancer (CRC) patients treated with standard adjuvant chemotherapy (ACHT) is highly variable. Genomic biomarkers and/or transcriptomic profiles identified lack of adequate validation. Aim of our study was to identify and validate molecular biomarkers predictive of …

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The smart city between European ambitions and Italian gaps: The challenge of urban sustainability

Cristina Napoli

ERRATUM

Enrico Mini, Ida Landini, Laura Lucarini, Andrea Lapucci et autres

The poly(ADP-ribose) polymerase (PARP) enzymes play a key role in the regulation of cellular processes (e.g., DNA damage repair, genomic stability). It has been shown that PARP inhibitors (PARPIs) are selectively cytotoxic against cells having dysfunctions in genes involved in DNA repair …

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