Xiumei Xiong

Effects of a WeChat-based PERMA model positive psychological intervention on Chinese women after termination of pregnancy: a randomized controlled trial

S. H. Ye, Xiumei Xiong, Zhumei Lin, Meirong Wen et autres

Objective To explore the effects of WeChat-based PERMA (Positive Emotion, Engagement, Relationships, Meaning, and Accomplishment) positive psychological intervention on psychological adaptation during puerperium among women who underwent termination of pregnancy (TOP), with a focus on evaluating its efficacy in alleviating grief, promoting …

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Short- and long-term efficacy evaluation of high-intensity focused ultrasound ablation and uterine artery embolization in the treatment of cesarean scar pregnancy (CSP) I and II: a retrospective cohort study

Li Huang, Lingna Huang, Bo Long, Fengning Lin et autres

Objectives To retrospectively analyze and compare the safety, effectiveness, and long-term pregnancy outcomes of high-intensity focused ultrasound (HIFU) versus uterine artery embolization (UAE), both followed by ultrasound-guided dilatation and curettage (USg-D&C), in treating cesarean scar pregnancy (CSP) type I and II, offering …

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Laparoscopic vs. laparotomy tubal recanalization for fertility restoration after tubal sterilization: a retrospective analysis

Yan Zhang, Yuan Lin, Xiujuan Chen, Xiaoqing Liu et autres

Objective To compare the therapeutic effects of laparoscopic recanalization and laparotomy recanalization on tubal patency restoration after tubal sterilization. Methods A retrospective analysis was conducted on the clinical data of 122 patients who underwent tubal sterilization surgery at one tertiary grade A …

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Network toxicology and single-cell analysis reveal key gene-mediated bisphenol a interference with granulosa cell function in polycystic ovary syndrome

Yan Zhang, Yuan Lin, Xiumei Xiong, Xiujuan Chen et autres

Background Bisphenol A (BPA), a typical endocrine-disrupting chemical, is implicated in the pathogenesis of Polycystic Ovary Syndrome (PCOS); however, the underlying molecular mechanisms and pathophysiological processes remain unclear. This study aims to decipher molecular interactions between BPA and PCOS-related genetic networks, and …

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Integrative bioinformatics, single-cell and experimental evidence for a BPA–m6A–apoptosis axis in granulosa cell dysfunction in polycystic ovary syndrome

Yan Zhang, Yuan Lin, Xiumei Xiong, Xiujuan Chen et autres

BACKGROUND: Polycystic ovary syndrome (PCOS) is increasingly viewed as an environmentally influenced, epigenetically mediated reproductive–metabolic disorder. Bisphenol A (BPA) exposure is higher in women with PCOS and has been linked to hyperandrogenism, insulin resistance and ovarian dysfunction, while N6-methyladenosine (m6A) dysregulation contributes …

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Heat Exposure Is Associated with High Risk of Six Major Adverse Pregnancy Outcomes: A Global Systematic Review and Meta-Analysis

Haijun Yan, Yanxin Wang, Zhuohang Che, Geng Guo et autres

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Practice guideline for the treatment and management of iatrogenic premature ovarian insufficiency

Xiangyan Ruan, Xu Che, Hefeng Huang, Chenghong Yin et autres

It is well known that premature ovarian insufficiency (POI) seriously affects the fertility, quality of life, and health of young women. A meta-analysis of global data indicated that the current population prevalence of POI is as high as 3.7 %, but exceeds …

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Medical treatment of acquired uterine arteriovenous fistulae related to pregnancy: 2 case reports and literature review

Lingna Huang, Lin Qiu, Jinwen Zhang, Hui Ye et autres

Uterine arteriovenous fistula (UAVF) is a rare form of uterine arteriovenous malformation, the most characteristic clinical symptom of which is intermittent vaginal bleeding. Currently, reports on the treatment of UAVF mainly focus on uterine artery embolization (UAE), high-intensity focused ultrasound (HIFU), and …

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Knowledge and attitudes of premenopausal women in southern China toward menopause and menopausal hormone therapy

Yan Zhang, Xiujuan Chen, Yuan Lin, Xiaoqing Liu et autres

OBJECTIVE: Menopause is a significant and natural phase in a woman's life, representing a transition that requires early understanding to manage its effects and promote overall well-being. This study aimed to evaluate the awareness, understanding and perceptions of menopause and menopausal hormone …

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Identification of crucial pathways and genes linked to endoplasmic reticulum stress in PCOS through combined bioinformatic analysis

Yan Zhang, Xiujuan Chen, Lin Yuan, Xiaoqing Liu et autres

Background Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic condition impacting millions of women worldwide. This study sought to identify granulosa cell endoplasmic reticulum stress (GCERS)-related differentially expressed genes (DEGs) between women with PCOS and those without PCOS using bioinformatics …

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Exploring the predictive value of complete blood count inflammatory parameters in early pregnancy for missed abortion

Lingna Huang, Xiumei Xiong

IntroductionThe aim of this study was to assess the potential role of complete blood count (CBC) inflammatory parameters in the diagnosis and management of missed abortions during early pregnancy through the analysis of their values.MethodsThe case group for our study comprised 500 …

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Preclinical development of a novel CCR8/CTLA-4 bispecific antibody for cancer treatment by disrupting CTLA-4 signaling on CD8 T cells and specifically depleting tumor-resident Tregs

Cuicui Guo, Xiaodong Dai, Yulei Du, Xiumei Xiong et autres

Anti-CTLA-4 antibodies faced challenges due to frequent adverse events and limited efficacy, which spurred the exploration of next-generation CTLA-4 therapeutics to balance regulatory T cells (Tregs) depletion and CD8 T cells activation. CCR8, identified primarily on tumor-infiltrating Tregs, has become a target …

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