Xiangyan Ruan

The feasibility of ovarian tissue cryopreservation in selected females after hematopoietic stem cell transplantation

Jiaojiao Cheng, Juan Du, Muqing Gu, Xiangyan Ruan et autres

We evaluated whether ovarian tissue cryopreservation (OTC) is a viable option for girls and young women who have already undergone hematopoietic stem cell transplantation (HSCT). We enrolled 142 patients who underwent OTC either before or after HSCT. Participants were categorized into three …

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A randomized controlled trial on the effect of Gushukang on bone mineral density in perimenopausal and postmenopausal women

Lu Liu, Xiangyan Ruan, Muqing Gu, Yanqiu Li et autres

Objective To study the effect of the traditional Chinese medicine Gushukang on bone mineral density (BMD) in perimenopausal and postmenopausal women.Methods In this randomized trial, 156 women were assigned to three groups (n = 52 each): hormone therapy (HT), Chinese medicine (CM, …

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Karyotype-based evaluation of ovarian reserve before ovarian tissue cryopreservation in Turner syndrome patients

Juan Du, Jiaojiao Cheng, Xiangyan Ruan, Muqing Gu et autres

BACKGROUND: Turner syndrome (TS) girls experience accelerated ovarian reserve depletion, exhibiting a strong demand for ovarian tissue cryopreservation (OTC) to preserve fertility and ovarian function. However, the current knowledge of OTC in TS is limited, and predicting follicular presence is insufficient. This …

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Materials-Driven Fluorescent Sensor Array of Dye-Derived Carbon Dots for Sensitive Detection of Multiple Proteins and the Cancer Biomarker Progesterone Receptor Membrane Component-1

Yuwei Guan, Mengying Zhang, Xiangyan Ruan, Yuejiao Wang et autres

Accurate protein recognition is crucial for early disease diagnosis and biomarker screening. Progesterone receptor membrane component-1 (PGRMC1) is a promising cancer biomarker, yet its sensitive and selective detection in complex biological samples remains challenging. Here, a molecularly programmable multichannel fluorescence sensor array …

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Effects of a mutation in the transmembrane and coiled-coil domains 2 gene on ovarian function and reproductive aging

Che Xu, Xiangyan Ruan, Yanqiu Li, Yu Yang et autres

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The Relationship Between Achievement Motivation, Team Belonging, and Sports Participation Among Chinese University Table Tennis Players

Xiangyan Ruan, Kyoung-Shil Park

Practice guideline for the treatment and management of iatrogenic premature ovarian insufficiency

Xiangyan Ruan, Xu Che, Hefeng Huang, Chenghong Yin et autres

It is well known that premature ovarian insufficiency (POI) seriously affects the fertility, quality of life, and health of young women. A meta-analysis of global data indicated that the current population prevalence of POI is as high as 3.7 %, but exceeds …

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Effect of oral contraceptive pretreatment on IVF outcomes in women with polycystic ovary syndrome using a long GnRH agonist protocol

Muqing Gu, Xiangyan Ruan, Yanqiu Li, Chanwei Jia et autres

OBJECTIVE: To evaluate the effect of oral contraceptive (OC) pretreatment on in vitro fertilization (IVF) outcomes in women with polycystic ovary syndrome (PCOS) undergoing the GnRH agonist (GnRH-a) long protocol, compared with other ovarian stimulation protocols. METHODS: This retrospective study included 121 …

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Hypoxia-preconditioned hUCMSCs protect frozen-thawed human ovarian tissue by modulating the HIF-1α/VEGF pathway

Muqing Gu, Xiangyan Ruan, Jiaojiao Cheng, Yanglu Li et autres

OBJECTIVE: To evaluate whether hypoxia-preconditioned human umbilical cord mesenchymal stem cells (hUCMSCs) can protect frozen-thawed human ovarian tissue via in vitro co-culture. METHODS: ‑MSCs group (normoxia‑preconditioned hUCMSCs co-culture), and H‑MSCs group (hypoxia‑preconditioned hUCMSCs co-culture). Tissues in the co-culture groups were subjected to …

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Advances in ovarian tissue cryopreservation and transplanta-tion for fertility preservation in prepubertal patients

Jiaojiao Cheng, Xiangyan Ruan, Juan Du, Muqing Gu

Ovarian tissue cryopreservation and transplantation is currently the only feasible method for preserving both fertility and ovarian endocrine function in prepubertal female patients. It is indicated for those requiring gonadotoxic therapies such as chemo-therapy, radiotherapy, or bone marrow transplantation for malignant diseases, …

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Revascularization of human ovarian cortical grafts is not equally efficient from both sides of the cortex tissue

Jiaojiao Cheng, Xiangyan Ruan, Juan Du, Fengyu Jin et autres

Research question Does early-phase revascularization of human ovarian cortical grafts exhibit spatial asymmetry between medullary and cortical surfaces in a xenotransplantation model? Design Cryopreserved ovarian tissue from five patients was transplanted bilaterally beneath the renal capsule of immunodeficient nude mice (medullary surface …

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Prevention and treatment of iatrogenic POI to protect fertility and ovarian function

Xiangyan Ruan, Alfred Otto Mueck

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