Carlos A. Flores

Return-aware platform experimentation: new directions for research

Jacqueline Doremus, Joel Persson, B.S. Thomas, Carlos A. Flores et autres

us, se (code pays fourni par la source)

Deleterious variants in the autophagy-related gene RB1CC1/FIP200 impair immunity to SARS-CoV-2

Renée M. van der Sluis, Kennith Brian Castelino, Bao‐cun Zhang, Andreas Ronit et autres

The clinical outcome of SARS-CoV-2 infection spans from asymptomatic viral elimination to lethal COVID-19 pneumonia, which is due to type I interferon (IFN) deficiency in at least 15–20% of cases. We report two unrelated male patients with critical COVID-19 who are heterozygous …

dk, fr, us, it, sa, kw, gr, co, il, ca, ua, ch, Maroc, se, au, es, br, be, in, tr, mk, mx, ae, no, jp, pl, ee, tw, hk, cn, ir, hu, sg, ie, Afrique du Sud (code pays fourni par la source)

The seven enigmas of SARS-CoV-2: From the past to the future

Evangelos Andreakos, Lisa M. Arkin, Paul Bastard, Alexandre Bolze et autres

Five years ago, we launched the COVID Human Genetic Effort. Our goal was to explain the clinical variability among SARS-CoV-2-exposed individuals by searching for monogenic inborn errors of immunity (IEI) and their phenocopies. We deciphered the pathogenesis of critical COVID-19 pneumonia and …

gr, us, fr, ch, ca, in, gb, se, it, be, dk, nl (code pays fourni par la source)

More Schooling Can Delay the Onset of Dementia Later in Life

Vikesh Amin, Jere Richard Behrman, Jason M. Fletcher, Carlos A. Flores et autres

us (code pays fourni par la source)

Causal Effects of Schooling on Memory at Older Ages in Six Low-and-Middle-Income Countries: Nonparametric Evidence with Harmonized Datasets

Vikesh Amin, Jere Richard Behrman, Jason M. Fletcher, Carlos A. Flores et autres

Higher schooling attainment is associated with better cognitive function at older ages, but it remains unclear whether the relationship is causal. We estimate causal effects of schooling on performances on the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) word-recall (memory) …

us (code pays fourni par la source)

More Schooling Can Delay the Onset of Dementia Later in Life

Vikesh Amin, Jere Richard Behrman, Jason M. Fletcher, Carlos A. Flores et autres

us (code pays fourni par la source)

Military Service during the Vietnam War Hurt Veterans’ Long-Term Health

Xintong Wang, Carlos A. Flores, Alfonso Flores‐Lagunes

us (code pays fourni par la source)

A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity

Fahd A. Al Qureshah, Jérémie Le Pen, Nicole A. de Weerd, Marcela Moncada‐Vélez et autres

Autosomal recessive deficiency of the IFNAR1 or IFNAR2 chain of the human type I IFN receptor abolishes cellular responses to IFN-α, -β, and -ω, underlies severe viral diseases, and is globally very rare, except for IFNAR1 and IFNAR2 deficiency in Western Polynesia …

sa, us, au, fr, ca, br, tr, mx, lb, sg, ae, hk, il, th, be, gb (code pays fourni par la source)

Polygenic risk of idiopathic pulmonary fibrosis and COVID-19 severity

Beatriz Guillén‐Guío, Itahisa Marcelino-Rodríguez, Jose Miguel Lorenzo-Salazar, Olivia C. Leavy et autres

Background: A shared genetic component between coronavirus disease 2019 (COVID-19) and idiopathic pulmonary fibrosis (IPF) has been described based on analyses of individual risk variants. Here we used a whole-genome polygenic risk score (PRS) approach to further evaluate age- and sex-stratified genetic …

gb, es, mx, nl (code pays fourni par la source)

Author response: Novel risk loci for COVID-19 hospitalization among admixed American populations

Silvia Diz‐de Almeida, Raquel Cruz, André Ducati Luchessi, Jose Miguel Lorenzo-Salazar et autres

es, br, us, mx, py, ar, bo, co (code pays fourni par la source)

Author response: Novel risk loci for COVID-19 hospitalization among admixed American populations

Silvia Diz‐de Almeida, Raquel Cruz, André Ducati Luchessi, Jose Miguel Lorenzo-Salazar et autres

The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested …

es, br, us, mx, py, ar, bo, co (code pays fourni par la source)

SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency

Yi‐Hao Chan, Vanja Lundberg, Jérémie Le Pen, Jiayi Yuan et autres

Inherited deficiency of the RNA lariat-debranching enzyme 1 (DBR1) is a rare etiology of brainstem viral encephalitis. The cellular basis of disease and the range of viral predisposition are unclear. We report inherited DBR1 deficiency in a 14-year-old boy who suffered from …

us, se, fr, it, Égypte, tr, sa, be, ae, ca, dk, cn (code pays fourni par la source)