du Bois Rm

The MCP-1-2518 (A to G) single nucleotide polymorphism in Czech patients with pulmonary sarcoidosis: association with Löfgren's syndrome.

Zdeňka Navrátilová, František Mrázek, Eva Kriegová, Beata Hutyrová et autres

BACKGROUND AND AIM: The chemokine Monocyte Chemoattractant Protein (MCP)-1/CCL2, a chemoattractant for mononuclear cells, has already been implicated in the pathogenesis of sarcoidosis. A single nucleotide polymorphism (SNP) located at the position -2518 (A to G) of the MCP-1 gene has been …

cz (code pays fourni par la source)

トリ愛好者肺の疾患標識としてのKL-6とSP-Dの分析

R Janssen, Jan C Grutters, Hajime Satō, Van Velzen-Blad H et autres

Analysis of IL6 and IL1A gene polymorphisms in UK and Dutch patients with sarcoidosis.

Jan C Grutters, Panagiotis Pantelidis, Ruven Hj, McGrath Ds et autres

BACKGROUND: Proinflammatory cytokines are a major determinant in the inflammatory events leading to sarcoidosis. Genetic variations in the genes encoding these cytokines might contribute to sarcoidosis susceptibility, disease severity and outcome. METHODS: In the present study we genotyped two clinically well-defined cohorts …

nl (code pays fourni par la source)

The importance of complete screening for amyloid fibril type and systemic disease in patients with amyloidosis in the respiratory tract.

Pallav L. Shah, Gillmore Jd, Copley Sj, Collins Jv et autres

BACKGROUND: Patients with symptomatic thoracic involvement by amyloidosis are virtually all of AL-type, and have historically been divided into systemic and localised disease, a subdivision that helps predict outcome and aids management. Assessment and classification of amyloid has evolved in recent years …

gb (code pays fourni par la source)

Idiopathic interstitial pneumonias: a re-appraisal of idiopathic pulmonary fibrosis.

Taylor Da, du Bois Rm

Over the last 30 years the clinical and histopathological definitions of the diffuse lung diseases have evolved considerably. Initially pathological entities were defined in parallel with clinico-radiological diagnoses, but these have more recently become consolidated into a more meaningful combined classification. These …

gb (code pays fourni par la source)

Management of idiopathic pulmonary fibrosis: prognostic indicators.

du Bois Rm

There now exists a number of approaches that can be used to predict likely responses to therapy and disease progression in idiopathic pulmonary fibrosis. These tools should be used in management decisions. It must be remembered that destroyed, fixed fibrotic lung will …

gb (code pays fourni par la source)

Interstitial lung disease: basic mechanisms and genetic predisposition.

Lympany Pa, du Bois Rm

Diffuse (interstitial) lung disease comprises a wide variety of relatively uncommon conditions, which present with characteristic clusters of clinical features and often with aberrant lung function. These diseases cause major morbidity and mortality due to lung injury and fibrosis. Some of these …

us (code pays fourni par la source)

Chemotactic cytokines (chemokines) and their role in physiological and immunopathological reactions.

Martin Petřek, du Bois Rm, Milada Šírová, E Weigl

cz (code pays fourni par la source)

Management of fibrosing alveolitis.

du Bois Rm

Fibrosing alveolitis kills half of those who suffer from it within 5 years of diagnosis. Its incidence appears to be increasing and the response to treatment is disappointing. This article explores the reasons why the response to treatment is poor and ways …

Pathogenetic mechanisms in the lung in systemic disease.

du Bois Rm

gb (code pays fourni par la source)

The density of HLA-DR antigen expression on alveolar macrophages is increased in pulmonary sarcoidosis.

Campbell Da, du Bois Rm, Butcher Rg, Poulter Lw

The density of HLA-DR antigen expression on alveolar macrophages obtained by bronchoalveolar lavage from sarcoidosis patients and normal control subjects was quantified using scanning and integrating microdensitometry in conjunction with a monoclonal mouse anti-human HLA-DR antibody directly conjugated to fungal glucose oxidase. …

Cells, enzymes and interstitial lung disease. The Philip Ellman Lecture.

Margaret E. H. Turner-Warwick, Haslam Pl, A Lukoszek, Philip J. Townsend et autres