Yafei Zhi

Data fusion of airfoil ice shapes with residual U-shaped convolutional neural network

Zhixu Jin, Zhixing Zhang, Wenqiang Zhang, Yafei Zhi et autres

cn, gb (code pays fourni par la source)

FBL promotes hepatocellular carcinoma tumorigenesis and progression by recruiting YY1 to enhance CAD gene expression

Yafei Zhi, Yan Guo, Shiliang Li, Xinyu He et autres

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Accumulating evidence suggests that epigenetic dysregulation contributes to the initiation and progression of HCC. We aimed to investigate key epigenetic regulators that contribute to tumorigenesis and progression, providing a theoretical …

cn, gb, kr (code pays fourni par la source)

RTN4IP1 Contributes to ESCC via Regulation of Amino Acid Transporters

Huifang Wei, Dengyun Zhao, Yafei Zhi, Qiong Wu et autres

Esophageal squamous cell carcinoma (ESCC) accounts for about 90% of esophageal cancer cases. The lack of effective therapeutic targets makes it difficult to improve the overall survival of patients with ESCC. Reticulon 4 Interacting Protein 1 (RTN4IP1) is a novel mitochondrial oxidoreductase. …

cn (code pays fourni par la source)

CHI-KAT8i5 suppresses ESCC tumor growth by inhibiting KAT8-mediated c-Myc stability

Dandan Zhang, Ming Jiang, Pan Li, Kyle Vaughn Laster et autres

The integrated analysis of histone modifier enzymes in solid tumors, especially in esophageal squamous cell carcinoma (ESCC), is still inadequate. Here, we investigate the expression levels of histone modifier enzymes in ESCC tissues. Notably, KAT8 (lysine acetyltransferase 8) is identified as a …

cn (code pays fourni par la source)

Multi-omics characterization of esophageal squamous cell carcinoma identifies molecular subtypes and therapeutic targets

Dengyun Zhao, Yaping Guo, Huifang Wei, Xuechao Jia et autres

Esophageal squamous cell carcinoma (ESCC) is the predominant form of esophageal cancer and is characterized by an unfavorable prognosis. To elucidate the distinct molecular alterations in ESCC and investigate therapeutic targets, we performed a comprehensive analysis of transcriptomics, proteomics, and phosphoproteomics data …

cn, kr (code pays fourni par la source)

Electromagnetic Performance Analysis of a Novel Variable Thickness Airborne Radome

Yafei Zhi, Pengcheng Wu, Jialin Cheng, Wen Yang et autres

Aiming at the problems of the distortion of the pattern, wave transmission rate degradation, excessive aiming error and cross-polarization level lift when electromagnetic wave passed through the dielectric radome, a novel airborne radome based on variable thickness design was proposed. Firstly, the …

cn (code pays fourni par la source)

miR‐132‐3p promotes heat stimulation‐induced esophageal squamous cell carcinoma tumorigenesis by targeting KCNK2

Jing Wang, Jiaqiong Li, Dan Cheng, Keke Zhang et autres

Epidemiological evidence supports that consumption of high-temperature food and beverages is an important risk factor for esophageal squamous cell carcinoma (ESCC); however, the underlying mechanism still remains unclear. Here, we established a series of animal models and found that drinking 65°C water …

cn, th (code pays fourni par la source)

BRD4 drives esophageal squamous cell carcinoma growth by promoting RCC2 expression

Qiong Wu, Fangfang Liu, Meng-Meng Ge, Kyle Vaughn Laster et autres

The low survival rate of esophageal squamous cell carcinoma patients is primarily attributed to technical limitations and a lack of insight regarding the molecular mechanisms contributing to its progression. Alterations in epigenetic modulators are critical to cancer development and prognosis. BRD4, a …

cn (code pays fourni par la source)

miR ‐17‐3p promotes the proliferation of multiple myeloma cells by downregulating P21 expression through LMLN inhibition

Xiang Pu, Yiu To Yeung, Jiheng Wang, Qiong Wu et autres

Multiple myeloma (MM), a hematological malignancy, has a poor prognosis and requires an invasive procedure. Reports have implicated miRNAs in the diagnosis, treatment and prognosis of hematological malignancies. In our study, we evaluated the expression profiles of miR-17-3p in plasma and bone …

cn (code pays fourni par la source)

Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model

Tingxuan Gu, Simin Zhao, Guoguo Jin, Mengqiu Song et autres

Although COVID-19 has become a major challenge to global health, there are currently no efficacious agents for effective treatment. Cytokine storm syndrome (CSS) can lead to acute respiratory distress syndrome (ARDS), which contributes to most COVID-19 mortalities. Research points to interleukin 6 …

cn, us (code pays fourni par la source)

Molecular mechanism of SARS-CoV-2 components caused ARDS in murine model

Tingxuan Gu, Simin Zhao, Guoguo Jin, Mengqiu Song et autres

Abstract COVID-19 has become a major challenge to global health, and until now, no efficient antiviral agents have been developed. The SARS-CoV-2 infection is characterized by pulmonary and systemic inflammation in severe patients, and acute respiratory distress syndrome (ARDS) caused respiratory failure …

cn, us (code pays fourni par la source)

Requirement of the isocitrate lyase gene ICL1 for VPS41-mediated starvation response in Cryptococcus neoformans

Zhe Xu, Yafei Zhi, Jianzhang Dong, Benfeng Lin et autres

Cryptococcus neoformans is a major cause of fungal meningitis in individuals with impaired immunity. Our previous studies have shown that the VPS41 gene plays a critical role in the survival of Cryptococcus neoformans under nitrogen starvation; however, the molecular mechanisms underlying VPS41-mediated …

cn (code pays fourni par la source)