Emad M. Elzayat

Protective and therapeutic roles of Withania Somnifera in cyclophosphamide-induced ovarian dysfunction in rats

Aliaa Makkawy M. Saleh, Emad M. Elzayat, Jehane I. Eid, Sherein S. Abdelgayed et autres

Abstract Background Chemotherapy-induced ovarian dysfunction is a major cause of premature ovarian insufficiency (POI), infertility, and follicular depletion. Cyclophosphamide (CP), a widely used alkylating chemotherapeutic agent, exerts pronounced gonadotoxic effects through DNA damage, oxidative and nitrosative stress, and inflammatory signaling. Objective To …

Égypte, us (code pays fourni par la source)

Surveillance of the antiviral activity and mechanism of action of newly synthesized spirocyclic thio-pyrimidinones against human adenovirus type 40

Esraa A. Manie, Samar Ragab, Ayman M. Sweed, Sherif Nasser et autres

Human adenoviruses (HAdVs) cause multiple common human infections; they are responsible for several upper and lower respiratory system and gastrointestinal diseases. There are no available approved antiviral treatments specific to HAdVs thus far; only a wide-spectrum antiviral can be used, and this …

Égypte (code pays fourni par la source)

Exploring the functional role of XIST in breast cancer from mechanisms to clinical implications

Nada I. Zyada, MAHMOUD M. KAMEL, Emad M. Elzayat, Abdel Hady A. Abdel Wahab

Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators in cancer biology, with the X-inactive specific transcript (XIST) playing a particularly significant role in breast cancer development and progression. This review summarizes current insights into XIST's mechanistic roles, highlighting its involvement in …

Égypte (code pays fourni par la source)

Adipose-derived mesenchymal stem cells attenuate doxorubicin-induced cardiomyopathy in rats: association with miR-146a/NF-κB/TLR-4 transcriptional modulation

Shorouk Mahmoud Hasan, Mohamed Hosney, Jehane I. Eid, Sherein S. Abdelgayed et autres

Abstract Background Doxorubicin (DOX) is an effective chemotherapeutic drug, but its clinical use is limited by dose-dependent cardiotoxicity and cardiomyopathy. Adipose-derived mesenchymal stem cells (ADMSCs) may offer cardioprotective effects through regenerative, antioxidant, and immunomodulatory mechanisms. This study investigated the therapeutic potential of …

Égypte, us (code pays fourni par la source)

Rhizosphere Microbiome Engineering for Climate-Smart Agriculture: From Synthetic Consortia to Precision Decision Support

Nourhan Fouad, Emad M. Elzayat, Dina Amr, Dina A. El-Khishin et autres

Rhizosphere microbiome engineering is a promising approach that can enhance crop resilience and input use efficiency by redirecting plant-microbe-soil interactions toward predictable functions. Here, we review the mechanistic bases underlying rhizosphere assembly and stability, including root exudate-mediated selection, priority effects, keystone taxa, …

Égypte, sa (code pays fourni par la source)

Combined mesenchymal stem cells and metformin therapy modulates key macromolecular pathways in pulmonary fibrosis based on evidence from untargeted metabolomics

Karim Morsi, Taghreed Khaled Abdelmoneim, Nada A. Youssef, Emad M. Elzayat et autres

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with limited therapeutic options, highlighting the need for novel interventions. Mesenchymal stem cells (MSCs) possess immunomodulatory and regenerative capacities, while metformin, a widely used antidiabetic agent, has recently shown anti-fibrotic …

Égypte (code pays fourni par la source)

Surveillance of the antiviral activity and mechanism of action of newly synthesized spirocyclicthiopyrimidinones against human adenovirus type 40

Esraa A. Manie, Samar Ragab, Ayman M. K. Sweed, Sherif Nasser et autres

Égypte (code pays fourni par la source)

Cavin gene family and caveolae-related disorders: pathogenetic roles and possible mechanisms

Youssef Osman, Nuraly S. Akimbekov, Emad M. Elzayat, Nourhan Hassan et autres

Cavins, in concert with caveolins, orchestrate the formation and function of caveolae-specialized invaginations of the plasma membrane involved in mechanotransduction, lipid homeostasis, and cell signaling. The Cavin family comprises four members: Cavins 1-3, which are broadly expressed, and Cavin4, which is muscle-specific. …

de, kz, Égypte (code pays fourni par la source)

Harnessing the plant-associated microbiome: Rhizosphere and endophyte plant growth-promoting bacteria (PGPB) to mitigate salt stress in the Egyptian wheat

Nourhan H. Fouad, Dina Amr, Emad M. Elzayat, Haytham Mohamed Abd-Elhalim et autres

Abstract Salt stress poses a significant threat to wheat productivity, particularly in arid and semi-arid regions such as Egypt, where soil salinity severely limits crop yield and long-term agricultural sustainability. With increasing recognition of the plant-associated microbiome as a key component of …

lb, Égypte, sa (code pays fourni par la source)

Liver Diseases Associated with Insulin Resistance: Exploring the Therapeutic Potential of the Green-derived Bioactive Lipopeptide Surfactin for the Prevention and Amelioration of Non-alcoholic Fatty Liver Disease

Omnia Mahareek, Hend Okasha, Samah Mamdouh, Emad M. Elzayat et autres

Abstract: Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in hepatocytes and is gradually becoming a global epidemic that can cause serious health problems. NAFLD can lead to hepatocellular carcinoma (HCC), cirrhosis, and death. The major causes are …

Égypte (code pays fourni par la source)

Nanoparticles in Wound Healing: Classification, Recent Advances, and Limitations

Mahetab Elmotazbellah, Mohamed A. N. Soliman, Mohamed N. Abd El-Ghany, Mohamed Abbas Shemis et autres

Égypte (code pays fourni par la source)

Modulation of experimental Alzheimer’s disease in rats through donepezil-loaded CSF implant

Lamyaa Osama, Shaimaa Ahmed ElShebiney, Hanan H. Beherei, Emad M. Elzayat et autres

Alzheimer's disease (AD) is a growing challenge worldwide, with current treatments largely symptomatic and limited. The current study aimed to introduce coated nanoporous membranes for localized drug delivery of donepezil, combining both antifouling activity and sustained drug release, unlike traditional Alzheimer's treatments …

Égypte (code pays fourni par la source)