Ayman M. K. Sweed

Design, synthesis, biological evaluation and mechanistic investigation of quinazolinone–hydrazonothioate conjugates against multidrug-resistant bacteria

Ayman M. K. Sweed, Mohamed Abdelraof, Ahmed H. Afifi, Mohamed N. El‐Bayaa et autres

Égypte, sa (code pays fourni par la source)

Surveillance of the antiviral activity and mechanism of action of newly synthesized spirocyclic thio-pyrimidinones against human adenovirus type 40

Esraa A. Manie, Samar Ragab, Ayman M. K. Sweed, Sherif Nasser et autres

Human adenoviruses (HAdVs) cause multiple common human infections; they are responsible for several upper and lower respiratory system and gastrointestinal diseases. There are no available approved antiviral treatments specific to HAdVs thus far; only a wide-spectrum antiviral can be used, and this …

Égypte (code pays fourni par la source)

Surveillance of the antiviral activity and mechanism of action of newly synthesized spirocyclicthiopyrimidinones against human adenovirus type 40

Esraa A. Manie, Samar Ragab, Ayman M. K. Sweed, Sherif Nasser et autres

Égypte (code pays fourni par la source)

A novel approach utilizing spirocyclic thiopyrimidinone compounds against herpes simplex virus with underlying antiviral mechanisms of action

Esraa A. Manie, Emad M. Elzayat, Sherif S. Ragab, Ayman M. K. Sweed et autres

In recent decades, viral outbreaks have significantly threatened global health, with herpes simplex virus type 2 (HSV-2) being one of the most prevalent infections. This study evaluated novel spiropyrimidine derivatives as potential antiviral agents against HSV-2, building on previous research that examined …

Égypte (code pays fourni par la source)

A novel approach utilizing spirocyclic thiopyrimidinone compounds against herpes simplex virus with underlying antiviral mechanisms of action

Esraa A. Manie, Emad M. Elzayat, Sherif S. Ragab, Ayman M. K. Sweed et autres

Égypte (code pays fourni par la source)

Click approach for the synthesis of 1,4-disubstituted-1,2, 3-triazoles of porphyrin-isatin/sulfa drug conjugates based on m-THPP

Ayman M. K. Sweed, Sherif S. Ragab, Mohamed Fikry, Reham A. Mohamed‐Ezzat et autres

New porphyrin-isatin/sulfa drugs conjugates based on symmetrical 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin ([Formula: see text]-THPP) with 1,4-regioisomers of 1,2,3-triazole linker were successfully synthesized. The constructed porphyrin-conjugates 15-19 and 22-24 contained mono-, tri- (unsymmetrical), or tetrafunctionalized units of isatin, sulfanilamide and sulfapyridine with 1,2,3-triazole linker. The synthesis …

Égypte (code pays fourni par la source)

Synthesis and Antiproliferative Properties of Some Spirocyclic Pyrimidine Hydrazones

Sherif S. Ragab, Ayman M. K. Sweed, Aladdin M. Srour

Abstract A new series of hydrazone derivatives incorporating spirocyclic aminopyrimidine with aryl alkanesulfonates were synthesized. The targeted products were obtained in excellent yields via an acid catalyzed reaction of spirocyclic hydrazinopyrimidine with aryl aldehyde sulfonates. The structures of the synthesized hydrazones were …

Égypte (code pays fourni par la source)

MTHPP monoacetic ester: unexpected formation, zinc metalation, thermal and photophysical properties

Ayman M. K. Sweed, Yasser M. Shaker, Sherif S. Ragab

Abstract In the current investigation we report an unexpected methyl esterification occurred during the coupling reaction of mTHPP monoacetic acid 2 with 3-amino-1,2,4-triazole in the presence of HBTU/DIPEA. The mechanism of this unexpected methyl esterification was studied, and the structure of the …

Égypte (code pays fourni par la source)

Design, synthesis, molecular dynamic simulation studies, and antibacterial evaluation of new spirocyclic aminopyrimidines

Sherif S. Ragab, Mohamed Abdelraof, Ahmed Abd Elkader El-Rashedy, Ayman M. K. Sweed

Égypte (code pays fourni par la source)

Design, Synthesis, Antiviral Evaluation, and Molecular Dynamics Simulation Studies of New Spirocyclic Thiopyrimidinones as Anti HCoV‐229E

Sherif S. Ragab, Ayman M. K. Sweed, Ahmed Abd Elkader El-Rashedy, Abdou Kamal Allayeh

The current pandemic threat presented by viral pathogens like SARS-CoV-2 (COVID-19) suggests that virus emergence and dissemination are not geographically confined. As a result, the quest for antiviral agents has become critical to control this pandemic. In the current study, we provide …

Égypte (code pays fourni par la source)

Synthesis and characterization of asymmetric oxyacetamide bridged porphyrin conjugates embedded with N-containing heterocycles

Ayman M. K. Sweed, Sherif S. Ragab, Yasser M. Shaker

In the search for photosensitizers based on 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin (m-THPP, 1), a novel series of asymmetric A3B porphyrin molecules with oxyacetamide linkers have been synthesized. A facile synthetic route was followed through the reaction of m-THPP derived porphyrin monoacid with amino-heterocyclic molecules in …

Égypte (code pays fourni par la source)

Design, Synthesis, and Antibacterial Activity of Spiropyrimidinone Derivatives Incorporated Azo Sulfonamide Chromophore for Polyester Printing Application

Sherif S. Ragab, Ayman M. K. Sweed, Zeinab K. Hamza, Elkhabiry Shaban et autres

Égypte, us (code pays fourni par la source)