Ajith Nagahawatte

Age distribution of respiratory syncytial virus disease in children younger than 5 years in low-income and middle-income countries: a systematic review and meta-analysis

Sarwat Mahmud, Kevin van Zandvoort, Ling Guo, You Li et autres

BACKGROUND: Low-income and middle-income countries (LMICs) bear the greatest burden of respiratory syncytial virus (RSV) disease. WHO recommends passive immunisation to protect infants younger than 6 months and, in some strategies, infants up to age 12 months, but detailed age data are …

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Informed Consent in Clinical Research

Ajith Nagahawatte

No abstract available

Use of the BIOFIRE® FILMARRAY® Pneumonia plus Panel to characterize the etiology of lower respiratory tract infections among hospitalized patients in Southern Province, Sri Lanka

Zachary A. Weishampel, Ajith Nagahawatte, Gaya Bandara Wijayaratne, Bradly P. Nicholson et autres

Lower respiratory tract infections (LRTIs) account for a heavy burden of illness in low- and middle-income country settings, but the etiology of these infections is often unknown. In this study, we applied the BIOFIRE ® FILMARRAY ® Pneumonia plus Panel, a multiplex …

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Diverse respiratory viruses detected among hospitalized patients with pneumonia in Sri Lanka and Vietnam

Phuong Thu Phan, Gaya Bandara Wijayaratne, Champica K. Bodinayake, Judith Uche Oguzie et autres

Objectives: We conducted surveillance for novel respiratory viruses among patients hospitalized with pneumonia in Sri Lanka and Vietnam. Methods: We enrolled patients from January 2020 to July 2022 at one major hospital each in Sri Lanka and Vietnam. The participants' nasopharyngeal swabs …

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Academic global health collaboration: the Ruhuna-Duke partnership

Champica K. Bodinayake, Ajith Nagahawatte, Vijitha De Silva, P. L. Ariyananda et autres

The role of institutional partnerships is increasingly recognized as a means of advancing our collective efficacy in improving public health. Shared challenges related to infectious and chronic diseases, as well as social determinants of health including environmental stressors, have led to a …

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Electronic Clinical Decision Support Tools to Manage Patients with Lower Respiratory Tract Infection: Clinicians’ Perspectives in Sri Lanka

Warsha De Zoysa, Dhammika Palangasinghe, Champica K. Bodinayake, Ajith Nagahawatte et autres

In low-resource settings, providers often manage lower respiratory tract infections (LRTIs) without diagnostic tests, which may cause antibacterial overuse. Electronic clinical decision support tools (eCDSTs) can support evidence-based decision-making and judicious use of antibacterials. This study aimed to explore the potential of …

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Antibacterial effect of aqueous leaf extracts of five spices

WGC Madushani, U. D. G. Y. Wijesiri, N. T. Wewelwala, T. D. Drieberg et autres

Introduction: Antimicrobial drug resistance has increased dramatically in the past years. Therefore, the urge to discover alternative natural antimicrobial agents has increased. Plants used in traditional medicine can be identified as potential candidates for the synthesis of novel drug compounds to act …

Host gene expression in the Nasopharynx can discriminate microbiologically confirmed viral and bacterial lower respiratory tract infection

L. Gayani Tillekeratne, Nicholas O’Grady, Maria Dolores Iglesias-Ussel, Jack G. Anderson et autres

Introduction: Distinguishing viral versus bacterial lower respiratory tract infection (LRTI) is challenging. We previously developed a rapid, host response-based test (Biomeme HR-B/V assay) using peripheral blood samples to identify viral versus bacterial infection. We assessed the performance of this assay when using …

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Physician knowledge, attitudes, and perceptions of antibiograms: a pre-implementation study in southern Sri Lanka

Lorenna C. Garcia-Bochas, Perla Medrano, Ajith Nagahawatte, C. L. Fonseka et autres

Objective: The purpose of this study is to explore physicians' knowledge, attitudes, and perceptions toward antibiograms and identify perceived barriers and facilitators to their implementation in a low-resource setting in Sri Lanka. Design: A qualitative study utilizing semi-structured interviews and thematic analysis. …

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Prevalence of anxiety and depression among patients hospitalised with acute febrile illness

Champica K. Bodinayake, Ajith Nagahawatte, Wasana Sevwandi Ranaweera Arachchige, Senuri C Sahabandu et autres

Introduction: Acute febrile illnesses (AFI) such as dengue, leptospirosis, and influenza result in large numbers of hospitalisation in the tropics. These illnesses may negatively impact patients’ mental health. The prevalence of anxiety and depression and risk factors associated with these conditions were …

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Prevalence and molecular epidemiology of methicillin-resistant Staphylococcus aureus in livestock farmers, livestock, and livestock products in southern Sri Lanka: A one health approach

Ruvini MP Kurukulasooriya, L. Gayani Tillekeratne, W. M. D. G. B. Wijayaratne, Champica K. Bodinayake et autres

Methicillin-resistant Staphylococcus aureus (MRSA) colonization can lead to subsequent severe infections. Unlike community and hospital-associated types, Livestock-associated MRSA (LA-MRSA) transmits to humans through direct contact with livestock and contaminated livestock products. This study aimed to investigate MRSA prevalence and molecular epidemiology in …

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Electronic Clinical Decision Support Tools: Strategies to Improve the Management of Lower Respiratory Tract Infections in Low-Resource Settings

L. Gayani Tillekeratne, Warsha De Soyza, Maria Dolores Iglesias-Ussel, Stefany Olague et autres

Lower respiratory tract infection (LRTI) is a common reason for hospitalization and antibacterial use globally. There is considerable overlap in the clinical presentation of bacterial and viral LRTIs. Low- or middle-income countries (LMICs) face the dual challenge of appropriately targeting antibacterials for …

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