Yanting Shen

Pannexin1 promotes cellular senescence by triggering mtDNA release to activate the cGAS-STING pathway

Jiaqi Li, Xin Zhao, Yanting Shen, Liuwei Huang et autres

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Hydrogen Sulfide-Activated Background-Free Self-Referenced Surface-Enhanced Raman Scattering Nanoprobe for Real-Time and Precise Monitoring of Drug-Induced Liver Injury Progression

Chunyuan Zhang, Wenhui Dong, Xi Zhang, Yuting Chen et autres

Accurate quantification and real-time monitoring of hydrogen sulfide (H2S) dynamics are critical for the early diagnosis and therapeutic intervention of liver injury, but remain challenging. Herein, we first report an activatable, background-free, ratiometric surface-enhanced Raman scattering (SERS) nanoprobe (Au@MBN@Au@PB, AMAP) for quantitative …

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ML-Driven Cellular Automata for Urban Functional Dynamics: Spatio-Temporal Modelling and Attribution in King's Cross

Yuxuan Li, Yiting Xu, Yanting Shen

Dihydroartemisinin for Treatment of Polycystic Ovary Syndrome: study protocol for a multi-centre placebo-controlled Randomized Clinical Trial

Liangshan Mu, Yanting Shen, Guiquan Wang, Changqin Liu et autres

ABSTRACT Introduction Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects reproductive-aged individuals. Our previous single-arm pilot trial showed that dihydroartemisinin (DHA) normalized menstrual cycles, ameliorated hyperandrogenemia, and reduced antral follicles in individuals with PCOS. However, there is still …

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The transcription factor LF1 controls compound leaf development by interacting with GmTCP3 and the GmLFY signaling network

Xuemei He, Min Zhang, Yanting Shen, Zongbiao Duan et autres

Leaf morphology varies substantially across plant species. In soybeans, the regulation of compound leaf development remains poorly characterized, despite its critical role in plant architecture. Some soybean cultivars have compound leaves with up to five leaflets, while most are trifoliolate. Using genetic …

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Genome editing or small molecule inhibition of KMT5A in CAR-T cells enhances antitumor immunity

Xiaoling Tian, Guolong Liu, Qiudao Wang, Yanting Shen et autres

Background Adoptive T-cell therapy has emerged as a promising therapeutic strategy for cancer treatment. However, clinical challenges persist, including the limited ability of CD8+T cells to infiltrate solid tumors and efficiently eliminate tumor cells. Given the critical role of epigenetic mechanisms in …

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Interference-free SERS tags for copper ion sensing upon hypoxia by in situ hot-spot generation

Chi Wang, Yan Fu, Yunqi Li, Yanting Shen

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Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury

Liuwei Huang, Yanting Shen, Xiaoling Pan, Jiaqi Li et autres

Acute kidney injury (AKI) can lead to chronic kidney disease (CKD), a transition driven by cellular senescence, a state of irreversible cell-cycle arrest. However, the molecular mechanisms promoting this pathological process remain unclear. Here we show that the channel protein Pannexin1 (Panx1) …

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Emerging implications of N6-methyladenosine in prostate cancer progression and treatment

Junyan Xu, Dajun Gao, Changjie Ren, Zhong Wang et autres

RNA modifications are widely distributed in almost all types of RNA, including mRNA, rRNA, miRNA, circRNA, and lncRNA, which are deeply involved in disease initiation and progression and are emerging therapeutic targets in diseases such as cancer, among which N6-methyladenosine (m6A) is …

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Corosolic acid increases the therapeutic effect of cisplatin on gastric cancer by regulating Gpx4-dependent ferroptosis

Liubing Lin, Jian Wang, Yanting Shen, Xiaolin Liu et autres

Aim: Cisplatin serves as a primary chemotherapeutic agent in the treatment of gastric cancer (GC), but resistance to cisplatin-based chemotherapeutic regimens hampers its clinical application. Corosolic acid (CA), a natural triterpenoid, exhibits both anti-inflammatory and anti-cancer activities. However, the effect of CA …

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Ratiometric SERS nanoprobe for ferroptosis monitoring in drug-induced liver injury via accurate detection of hydrogen peroxide in endoplasmic reticulum

Hailan Jia, Fengxian Wang, Chi Wang, Dong Wang et autres

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An automatic patient-specific quality assurance with a novel DVH scoring algorithm for volumetric modulated arc therapy of cervical cancer

Ji Zhang, Boda Ning, Xiaotong Jin, Yanting Shen et autres

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