Nan Hee Lee

Aberrant Fibro-Adipogenic Progenitor Subpopulations Drive Volumetric Muscle Loss-Induced Fibrosis

Shannon E. Anderson, Lauren A. Hymel, Hongmanlin Zhang, Jay M. McKinney et autres

Volumetric muscle loss (VML) injuries result in chronic fibrosis, inflammation, and persistent functional deficits. Fibro-adipogenic progenitor (FAP) cells are a heterogeneous, muscle-resident stromal cell population that play a crucial role in muscle regeneration, but also contribute to fibrosis in muscle disease. The …

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Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors

Yunki Lee, Jeongmoon J. Choi, Song Ih Ahn, Nan Hee Lee et autres

Abstract Exposure of a young systemic milieu reveals remarkable rejuvenation effects on aged tissues, including skeletal muscle. Although some candidate factors have been reported, the exact underlying mechanisms of putative rejuvenating factors remain elusive, mainly due to the experimental challenges of using …

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Regenerating motor neurons prime muscle stem cells for myogenesis by enhancing protein synthesis and mitochondrial bioenergetics

Jeongmoon J. Choi, Eun Jung Shin, Woojin M. Han, Shannon E. Anderson et autres

SUMMARY Throughout life, skeletal muscle, the arbiter of voluntary movements, is maintained by a population of skeletal muscle-dedicated stem cells, called muscle satellite cells (MuSCs). Similar to other adult stem cells, the function of MuSCs is tightly coordinated by the cellular and …

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Superoxide-mediated oxidative stress accelerates skeletal muscle atrophy by synchronous activation of proteolytic systems

Young Charles Jang, Karl A. Rodriguez, Michael S. Lustgarten, Florian L. Müller et autres

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Transplantation of Muscle Stem Cell Mitochondria Rejuvenates the Bioenergetic Function of Dystrophic Muscle

Mahir Mohiuddin, Jeongmoon J. Choi, Nan Hee Lee, Hyeonsoo Jeong et autres

Summary Mitochondrial dysfunction has been implicated in various pathologies, including muscular dystrophies. During muscle regeneration, resident stem cells, also known as muscle satellite cells (MuSCs), undergo myogenic differentiation to form de novo myofibers or fuse to existing syncytia. Leveraging this cell-cell fusion …

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The Muscle Stem Cell Mediates Remodeling of Skeletal Muscle Mitochondrial Networks

Mahir Mohiuddin, Nan Hee Lee, Jeongmoon J. Choi, Shannon E. Anderson et autres

Skeletal muscle regeneration is an energy‐demanding biological process that relies on mitochondria to generate ATP. While interfibrillar mitochondrial networks in healthy skeletal muscle fibers exhibit an organized architecture segregated into columns along the Z‐line of the myofiber, regenerating fibers demonstrate altered mitochondrial …

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Critical Limb Ischemia Induces Remodeling of Skeletal Muscle Motor Unit, Myonuclear-, and Mitochondrial-Domains

Mahir Mohiuddin, Nan Hee Lee, June Young Moon, Woojin M. Han et autres

Critical limb ischemia, the most severe form of peripheral artery disease, leads to extensive damage and alterations to skeletal muscle homeostasis. Although recent research has investigated the tissue-specific responses to ischemia, the role of the muscle stem cell in the regeneration of …

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Ischemia-reperfusion Injury Remodels Skeletal Muscle Motor Unit, Myonuclear-, And Mitochondrial-domains

Nan Hee Lee, Mahir Mohiuddin, Austin Moon, Woojin M. Han et autres

Peripheral artery disease (PAD) is a significant medical condition caused by blockages in the arteries of the leg. Some PAD patients progress to critical limb ischemia (CLI) and major amputation. While recent regenerative medicine approaches on collateral vessel formation have made some …

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Muscle Stem Cell‐Nerve‐Vasculature Interactions Modulate Tissue Regeneration Following Critical Limb Ischemia

Mahir Mohiuddin, Nan Hee Lee, Austin Moon, Woojin M. Han et autres

Critical limb ischemia, the most severe form of peripheral artery disease, is a degenerative cardiovascular disease characterized by abnormal perfusion to the limbs due to occlusions of the blood vessels. Although recent developments toward revascularization therapies have been introduced, the myopathy and …

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The Effects of Parenting Attitudes and Self-Esteem on Smartphone Overuse: Self-esteem Mediation - A senior in elementary school

Ju Young A, Hyung Bin Kim, Nan Hee Lee

Critical Limb Ischemia Induces Remodeling of Skeletal Muscle Motor Unit and Myonuclear- and Mitochondrial-Domains

Mahir Mohiuddin, Nan Hee Lee, June Young Moon, Woojin M. Han et autres

Abstract Critical limb ischemia, the most severe form of peripheral artery disease, leads to extensive damage and alterations in skeletal muscle homeostasis. Although recent developments towards revascularization therapies have been introduced, there has been limited research into treatments for ischemic myopathy. To …

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Jumping Exercise Restores Stretching-Induced Power Loss in Healthy Adults

Hyun Chul Jung, Nan Hee Lee, Sukho Lee

Th e purpose of this study was to examine the acute eff ects of jumping exercise (JE) immediately aft er diff erent stretching protocols on fl exibility and power in healthy adults.Th is study was conducted with a balanced crossover design.Th irteen …

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