Jinsong Zhang

Chinese Expert Consensus on Integrated Chinese and Western Medicine for the Treatment of Tic Disorders

Rong Ma, Sumei Wang, Yi Zheng, Jianmin Chen et autres

OBJECTIVE: Tic disorders are neurodevelopmental conditions that manifest in childhood or adolescence and can significantly impact the quality of life of affected children and their families to varying degrees. Integrated traditional Chinese and Western medicine treatment strategies have demonstrated more pronounced efficacy …

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Methodological concerns about score of delayed neuropsychiatric sequelae after carbon monoxide poisoning

Qifang Shi, Jinsong Zhang

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Clinical Application of 25-MHz Ultrasound Biomicroscopy for Lens Opacity Degree Measurements in Phacoemulsification

Fangkun Zhao, Jiaming Yu, Qi-Chang Yan, Jinsong Zhang et autres

Purpose: To evaluate the correlation between lens opacity degrees and phacoemulsification cumulated dissipated energy (CDE) values in patients with age-related cataract by applying 25-MHz panoramic ultrasound biomicroscopy (UBM). Methods: This observational study was conducted in 227 patients (294 eyes) with age-related cataract. …

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Research progress of epithelial-mesenchymal transformation in posterior subcapsular opacity

Tong Yu, Jing Wang, Jinsong Zhang

Cataract is the first blinding eye disease in China and the main cause of blindness in most countries in the world. Currently, surgery operation is the only effective treatment. Posterior capsular opacification(PCO)is a common complication after cataract surgery, and it is also …

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Acute lens opacity induced by different kinds of anesthetic drugs in mice

Xiaotong Li, Qin Yu, Jiangyue Zhao, Jinsong Zhang

AIM: To study whether specific anesthetic drugs or tear layer evaporation was primarily responsible for the acute cataract and what the change of lens structure is in anesthetized mice. METHODS: Five groups were set up in the experiment: Group A (topicamide and …

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Lens-specific conditional knockout of Msx2 in mice leads to ocular anterior segment dysgenesis via activation of a calcium signaling pathway

Wenting Yu, Ziyan Yu, Danhong Wu, Jiao Zhang et autres

Ocular anterior segment dysgenesis (ASD) is a failure of normal development of anterior structures of the eye, leading to lens opacification. The underlying mechanisms relating to ASD are still unclear. Previous studies have implicated transcriptional factor muscle segment homeobox 2 (Msx2) in …

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A novel missense mutation of CRYGS underlies congenital cataract in a Chinese family

Tianxiao Zhang, Lulu E. Yan, Yunji Leng, Chen Chen et autres

Congenital cataract is a clinically and genetically heterogeneous disease. In this study, we examined a five-generation Chinese family with autosomal dominant nuclear congenital cataracts by whole exome sequencing. A novel heterozygous missense mutation c.199T>A, p.(Tyr67Asn) in CRYGS was identified in this family. …

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Lens-specific deletion of the Msx2 gene increased apoptosis by enhancing the caspase-3/caspase-8 signaling pathway

Ziyan Yu, Wenting Yu, Jia‐Bao Liu, Danhong Wu et autres

Objective To investigate the influence of Msx2 conditional gene knockout during lens development in mice. Methods Lens-specific Msx2 knockout mice were generated using the Cre-loxP system. The eyes of Msx2 conditional knockout ( Msx2CKO) and wild-type ( Msx2WT) mice were examined during …

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Theme trends and knowledge structure on choroidal neovascularization: a quantitative and co-word analysis

Fangkun Zhao, Bei Shi, Ruixin Liu, Wenkai Zhou et autres

BACKGROUND: The distribution pattern and knowledge structure of choroidal neovascularization (CNV) was surveyed based on literatures in PubMed. METHODS: Published scientific papers about CNV were retrieved from Jan 1st, 2012 to May 31st, 2017. Extracted MeSH terms were analyzed quantitatively by using …

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miR-211 regulates the antioxidant function of lens epithelial cells affected by age-related cataracts

Bo Lü, Ian T. Christensen, Liwei Ma, Tao Yu et autres

AIM: To investigate the effects and mechanism of miR-211 in mediating the antioxidant function of lens epithelial cells affected by age-related cataracts. METHODS: Real-time quantitative polymerase chain reaction (RT-qPCR) was used to detect miR-211 expression in the anterior lens capsules of healthy …

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Effect of miR-138 on the antioxidant function of lens epithelial cells affected by age-related cataracts

Bo Lü, Liwei Ma, Xinling Wang, Xiao Han et autres

AIM: To investigate the effects and mechanism of miR-138 in mediating the antioxidant function of lens epithelial cells affected by age-related cataracts. METHODS: Real-time quantitative PCR(RT-qPCR)was used to detect miR-138 expression in the anterior lens capsules of healthy people, the anterior lens …

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Knockdown of dickkopf2 inhibits vascular endothelia growth factor expression through the Wnt/β-catenin signaling pathway in human retinal pigment epithelial cells under hypoxic conditions

Yu Xia Zhao, Bin Wu, Ye Liu, Jun Xu et autres

Hypoxia has been demonstrated to be a proangiogenic factor that induces vascular endothelial growth factor (VEGF) in retinal pigment epithelial (RPE) cells. Dickkopf2 (DKK2), originally known as Wnt antagonist, has recently been demonstrated to have an important regulatory role in angiogenesis; however, …

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