Junhong Jiang

CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8+CD103+ cDC1 and TRM cell responses

Zhaojia Wu, Zhenyu Yang, Tauqeer Iftikhar, Gary Groot et autres

Melanoma is one of the deadliest forms of skin cancer. Irreversible electroporation (IRE) is an innovative, non-thermal ablation technology for treating irresectable solid cancers. However, most IRE treatments are incapable of cancer eradication and only temporarily prolong patient survival. In this study, …

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Paxlovid plus glucocorticoids treatment in severe Omicron infected patients with hypoxaemia: A prospective multiple-center cohort study

Yuji Wang, Nan Su, Junhong Jiang, Guifang Xu et autres

BACKGROUND: Administration of Paxlovid in early stage has been proved to reduce the risk of hospitalization or death by 89% in mild to moderate COVID-19 patients with high-risk. There were few evidences of Paxlovid in severe COVID-19 patients. RECOVERY study has previously …

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m6A ‐Mediated Methylation Patterns and Their Association With Obstructive Sleep Apnea in Lung Adenocarcinoma

Lei Xia, Zhuodong Chai, Xiaoying Wei, Daxiong Zeng et autres

BACKGROUND: Epigenetic regulation significantly affects immune responses in lung adenocarcinoma (LUAD). However, the role of RNA N6-methyladenosine (m6A) modification, especially in obstructive sleep apnea-hypopnea syndrome (OSAHS) within LUAD, is not well understood. METHODS: This study examined m6A modification patterns in 973 LUAD …

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YY1: A Master Regulator at the Crossroads of Targeted Cancer Therapy - A Commentary

Junhong Jiang

Our recent publication entitled “YY1 downregulation underlies therapeutic response to molecular targeted agents” represents a significant advancement in our understanding of the molecular mechanisms governing drug resistance in oncogene-addicted cancers [1].

Controlling nosocomial transmission of respiratory infections in neurological wards: insights from COVID-19 pandemic data

W M Xie, Chengyue Zhu, Yue Dong, Junqing Li et autres

BACKGROUND: Transmissible diseases pose significant risks within healthcare facilities, which can lead to accelerated viral spread and exacerbate healthcare burdens, particularly for patients with severe conditions. During the COVID-19 pandemic, numerous cases of nosocomial infections were reported, underscoring the shortcomings of current …

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Influence of bad contact electrode on electrical impedance tomography data quality: a perspective of clinical application

Sini He, Meng Dai, Zhanqi Zhao, Peng Peng et autres

Abstract This study aimed to evaluate the effect of bad contact electrodes on the quality of electrical impedance tomography (EIT) data and the reliability of lung ventilation imaging. Thirty healthy volunteers were examined using EIT under normal relaxed tidal breathing in a …

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The Association Study Between Cytokines and the Risk for Cerebral Palsy

Bensong Wang, Fan Wang, Li Yang, Junhong Jiang et autres

Background: Cerebral palsy (CP) is a debilitating condition characterized by abnormal movement or posture beginning early in development. Recent evidence has shown that immunological abnormalities are associated with an increased risk of CP. However, there are no valuable biomarkers for CP diagnosis. …

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Galactose oxidase oxidation and glycosidase digestion for glycoRNA analysis

Jianbo Deng, Xinyu Miao, Xiaotong Wang, S. M. Wen et autres

Solid-phase glycoRNA enrichment provides a universal approach for capturing glycosylated RNAs, enabling the identification of glycoRNAs and facilitating functional studies.

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[Clinical Characteristics of Pneumocystis Jiroveci Pneumonia after Allogeneic Hematopoietic Stem Cell Transplantation].

Jing Xia, Junhong Jiang, Ye Zhao, Xiao Ma et autres

OBJECTIVE: To summarize the clinical characteristics of patients with combined pneumocystis jiroveci pneumonia (PJP) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS: The clinical manifestations, laboratory tests, imaging findings, and treatment outcomes of 21 allo-HSCT patients with PJP diagnosed at the First …

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Study on the complications after implantation of different types of metal stents in rabbit trachea

Zhenyu Yang, Ziyi Liu, Jie Zhang, Xiaoxiao Li et autres

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Expert consensus on the multidisciplinary diagnosis and treatment of multiple ground glass nodule-like lung cancer (2024 Edition) ∆

Baodong Liu, Xin Ye, Weijun Fan, Xiuyi Zhi et autres

ABSTRACT: This expert consensus reviews current literature and provides clinical practice guidelines for the diagnosis and treatment of multiple ground glass nodule-like lung cancer. The main contents of this review include the following: ① follow-up strategies, ② differential diagnosis, ③ diagnosis and …

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Study on the rationality of small diameter metallic airway stent in treatment of tracheal stenosis in injured rabbits

Xiaoxiao Li, Changguo Wang, Ziyi Liu, Kai Wu et autres

BACKGROUND: To observe the occurrence of related complications after self-expandable metallic (SEM) airway stents implantation with different diameters at different time points, and to provide theoretical basis for the optimal chioce of existing airway stents in clinical practice. METHODS: Healthy New Zealand …

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