Adrian A. M. Masclee

Altered gastrointestinal motility after bariatric surgery: consequences, complications and clinical considerations

Gwen Masclee, Adrian A. M. Masclee

INTRODUCTION: Bariatric surgical interventions such as laparoscopic sleeve gastrectomy (LSG), Roux-en-Y gastric bypass (RYGB), One-Anastomosis Gastric Bypass (OAGB) and Laparoscopic Adjustable Gastric Banding (LAGB) have proven to be effective in long-term management of obesity. These procedures result in changes in anatomy and …

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Gut–brain neuromodulators for IBS: what's in a name?

Adrian A. M. Masclee, Gwen Masclee

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Contributors

Sascha R.A. Alles, Javad Anjom-Shoae, Swapnali Barde, Dennis D. Black et autres

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CCK and the gallbladder

Adrian A. M. Masclee, Gwen Masclee

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Study protocol: the ‘Endoscope CRC’ cohort, a prospective biobank study on the development and evaluation of diagnostic and prognostic biomarker profiles for colorectal cancer and premalignant lesions

Hao Cheng, Robert van Vorstenbosch, Daisy Jonkers, Adrian A. M. Masclee et autres

INTRODUCTION: Early detection of colorectal cancer (CRC) and clinically relevant (advanced) adenomas leads to a significant reduction of CRC-related mortality and morbidity. However, the faecal immunochemical test (FIT) suffers from a high number of false-positive results and is insensitive to detecting advanced …

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The Potential Role for Impaired Mucosal Integrity in the Generation of Esophageal Pain Using Capsaicin in Humans: An Explorative Study

Annick M. E. Alleleyn, Dániel Keszthelyi, Nicolaas Fedde Rinsma, Kata Csekő et autres

INTRODUCTION: Esophageal pain is mediated by sensory nerves, most importantly by the activation of the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor. TRPV1 is activated and sensitized by a broad range of pungent compounds, as well as inflammatory mediators and tissue …

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Positive Health dialogue tool and value-based healthcare: a qualitative exploratory study during residents’ outpatient consultations

Lotte A. Bock, Cindy Noben, Gili Yaron, Erwin L. J. George et autres

OBJECTIVE: To explore how residents experienced the application of the Positive Health dialogue tool (PH-tool) during outpatient consultations and its influence on the delivery of value-based healthcare (VBHC). DESIGN: Qualitative study using non-participant observations of outpatient consultations during which residents used the …

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Review on the Regional Effects of Gastrointestinal Luminal Stimulation on Appetite and Energy Intake: (Pre)clinical Observations

Jennifer Wilbrink, Gwen Masclee, Tim Klaassen, Mark van Avesaat et autres

Macronutrients in the gastrointestinal (GI) lumen are able to activate "intestinal brakes", feedback mechanisms on proximal GI motility and secretion including appetite and energy intake. In this review, we provide a detailed overview of the current evidence with respect to four questions: …

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Absorption of nonheme iron during gastric acid suppression in patients with hereditary hemochromatosis and healthy controls

Wenke Moris, Pauline Verhaegh, Jef Verbeek, Dorine W. Swinkels et autres

This study confirms that lowering gastric acidity by proton pump inhibitors results in a reduction in iron absorption in patients with hemochromatosis and not in healthy control subjects. The presupposition that a decrease in hepcidin concentration in healthy control subjects in response …

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Psychometric evaluation of an experience sampling method–based patient‐reported outcome measure in functional dyspepsia

Tim Klaassen, Fabiënne G. Smeets, Lisa Vork, Jan Tack et autres

BACKGROUND: Due to important biases, conventional end-of-day and end-of-week assessment methods of gastrointestinal symptoms in functional dyspepsia (FD) are considered suboptimal. Real-time symptom assessment based on the experience sampling method (ESM) could be a more accurate measurement method. This study aimed to …

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Control Crohn Safe with episodic adalimumab monotherapy as first-line treatment study (CoCroS): study protocol for a randomised controlled trial

Laura Janssen, Mariëlle Romberg‐Camps, A Van Bodegraven, J Haans et autres

INTRODUCTION: Crohn's disease (CD) is a chronic inflammatory bowel disease with a heterogeneous clinical presentation, relapse rate and treatment response. At present, no markers are available to adequately predict disease course at diagnosis. To prevent overtreatment of patients with a relative mild …

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Effects of gastrointestinal delivery of non-caloric tastants on energy intake: a systematic review and meta-analysis

Tim Klaassen, Dániel Keszthelyi, Freddy J. Troost, Aalt Bast et autres

PURPOSE: Taste receptors are expressed throughout the gastrointestinal tract. The activation of post-oral taste receptors using tastants could provide a non-invasive treatment option in combating the obesity epidemic. The aim of this review was to examine the effect of post-oral delivery of …

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