Christof Ludescher

Janus‐faced course of COVID‐19 infection in patients with hematological malignancies

Rosa Bellmann‐Weiler, Francesco Robert Burkert, Theresa Schwaiger, Stephan Schmidt et autres

None of the authors have a conflict of interest in association with that study.

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Effect of Cyclosporin A in a Patient with Refractory Nephrotic Syndrome Associated with B Chronic Lymphocytic Leukemia

Wolfgang Eisterer, U Neyer, Wolfgang Hilbe, Gabriel Diem et autres

We report on a patient with an almost 20-year history of B chronic lymphocytic leukemia (B-CLL). During the last 2 years, the patient developed nephrotic syndrome (NS) due to membranous glomerulonephritis (MN), refractory to standard therapeutic regimens. Neither NS nor B-CLL responded …

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Spontaneous remission in a secondary acute myelogenous leukaemia following invasive pulmonary aspergillosis

Alexandar Tzankov, Christof Ludescher, Hans C. Duba, Martin Steinlechner et autres

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Phenotypic and Functional Lymphocyte Recovery After CD34 + -Enriched Versus Non-T Cell-Depleted Autologous Peripheral Blood Stem Cell Transplantation

David Nachbaur, Gaby Kropshofer, Andreas Heitger, Karla Lätzer et autres

To determine the effect of CD34+ selection on immune recovery after high-dose chemo/radiotherapy in the setting of autologous stem cell transplantation (ASCT), we analyzed quantitative and qualitative lymphocyte reconstitution for up to 1 year post-transplantation in 27 consecutive adult patients receiving either …

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Atorvastatin therapy reduces circulating TH1-lymphocytes in patients with stable angina

Hannes Franz Alber, Matthias Frick, Christof Ludescher, Otmar M. Pachinger et autres

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Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells

C. Murr, Heinz Zoller, M HAUN, Bernhard Widner et autres

In order to examine the regulatory effects of major Th1-derived cytokines, such as IL-12, and Th2 cytokines, IL-4 and IL-10, on the formation of neopterin and degradation of tryptophan, two metabolic pathways induced by interferon-gamma (IFN-gamma) in human monocytes/macrophages, we investigated the …

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Reversal of multidrug resistance by the staurosporine derivatives CGP 41251 and CGP 42700

Irene Utz, Martin Spitaler, Maria Rybczyńska, Christof Ludescher et autres

It has been shown previously that the staurosporine derivative CGP 41251, a specific inhibitor of protein kinase C (IC50 = 50 nM), exhibits antitumor activity and reverses mdr1 mediated multidrug resistance. At present, the compound is evaluated as an anticancer drug in …

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Reversal of multidrug resistance by the staurosporine derivatives CGP 41251 and CGP 42700

Irene Utz, Martin Spitaler, Maria Rybczyńska, Christof Ludescher et autres

Differential activity of P‐glycoprotein in normal blood lymphocyte subsets

Christof Ludescher, Georg Pall, Eveline U. Irschick, Günther A. Gastl

To better understand the phenomenon of P-glycoprotein (P-170) expression we investigated lymphocyte subpopulations for P-170 function in healthy volunteers. Studies were based on three-colour flow cytometry including the fluorescent probe rhodamine 123 (Rh123), which is transported by P-170. Marked Rh123 efflux was …

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CD34+-selected autologous peripheral blood stem cell transplantation (PBSCT) in patients with poor-risk hematological malignancies and solid tumors. A single-centre experience

David Nachbaur, F. M. Fink, Walter Nußbaumer, Anne Gächter et autres

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Multidrug resistance in acute leukemia: a comparison of different diagnostic methods

Georg Pall, Martin Spitaler, Johann Hofmann, J. Thaler et autres

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Cytokine Priming of the Granulocyte Respiratory Burst in Myelodysplastic Syndromes

August Felix Zabernigg, Wolfgang Hilbe, Wolfgang Eisterer, Richard Greil et autres

Increased susceptibility to infections in patients with myelodysplastic syndromes (MDS) is thought to be due to neutropenia as well as functional abnormalities of neutrophils. In the present study we examined the effect of two different stimulants (fMLP, PMA) and three cytokines (alphaTNF, …

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