Jordan Tang

Micro/Nanobubble-Assisted Lipotransfer

Faris F Halaseh, Arya Sherafat, Daniel P. Zaki, Leonardo Alaniz et autres

OBJECTIVE: Retention rates of lipotransfer remain variable, with the underlying cause associated with tissue oxygenation and blood supply barriers. One promising new method of improving tissue oxygenation is micro/nanobubbles (MNBs), which are small gas bubbles (<100 μm) generated within a saline solution. …

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Improving Fat Graft Retention with Micro/Nanobubbles in Vivo

Daniel Zaki, Lohrasb Ross Sayadi, Faris Halaseh, Jordan Tang et autres

PURPOSE: Fat grafting is one of the most popular procedures in plastic and reconstructive surgery.1 However, retention rates of transplanted fat remain variable, often rendering unpredictable outcomes in the long term. Inadequate tissue oxygenation during the transplant process is thought to play …

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Cover Feature: Highly Selective and Potent Human β‐Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X‐ray Structure and Structure–Activity Relationship Studies (ChemMedChem 5/2019)

Arun Kumar Ghosh, Margherita Brindisi, Yu‐Chen Yen, Emma K. Lendy et autres

The Cover Feature shows the X-ray structure of β-secretase 1 bound to compound 2a (top). The structure was utilized to create an active model of 2a with β-secretase 2, which led to the design and synthesis of highly potent and selective β-secretase …

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Cardosin A endocytosis mediated by integrin leads to lysosome leakage and apoptosis of epithelial cells

Hao Wu, Pedro de Souza Castanheira, Carlos Faro, Jordan Tang

Cardosin A is an aspartic protease present in large amount in the pistils of cardoon flowers. This protease is known to contain an -Arg-Gly-Asp- (RGD) motif located on the molecular surface. In this study, we found that isolated recombinant cardosin A attached …

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Highly Selective and Potent Human β‐Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X‐ray Structure and Structure–Activity Relationship Studies

Arun Kumar Ghosh, Margherita Brindisi, Yu‐Chen Yen, Emma K. Lendy et autres

Abstract Herein we present the design, synthesis, and biological evaluation of potent and highly selective β‐secretase 2 (memapsin 1, beta‐site amyloid precursor protein cleaving enzyme 2, or BACE 2) inhibitors. BACE2 has been recognized as an exciting new target for type 2 …

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Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand

Arun Kumar Ghosh, Koena Ghosh, Margherita Brindisi, Emma K. Lendy et autres

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Fixing Vertebral Compression Fractures with Medtronic

Kelly Fitzgerald, Trevor Bingham, Alex Denbaugh, Jordan Tang et autres

CCDC 1565312: Experimental Crystal Structure Determination

Arun Kumar Ghosh, Koena Ghosh, Margherita Brindisi, Emma K. Lendy et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1′-P2′ ligands

Arun Kumar Ghosh, Margherita Brindisi, Yu‐Chen Yen, Emilio L. Cárdenas et autres

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C.A.R.E (Cohort Assessment & Retrieval Environment)

Kyle Kent Edward Ellis, Payal Deepak Shah, Jordan Tang

The purpose of clinical trials is to explore whether a medical treatment is safe and effective for humans or to enhance preexisting methods. The identification of patients who satisfy a set of predefined criteria for the trial is instrumental. However, the process …

Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes

Arun Kumar Ghosh, Bhavanam Sekhara Reddy, Yu‐Chen Yen, Emilio L. Cárdenas et autres

Design, synthesis and evaluation of very potent and selective β-Secretase 2 (memapsin 1, BACE 2) inhibitors are described. The inhibitors were designed specifically to interact with the S2'-site of β-secretase 2 to provide >170,000-fold selectivity over β-secretase (BACE 1) and >15,000-fold selectivity …

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Prospects of β‐Secretase Inhibitors for the Treatment of Alzheimer’s Disease

Arun Kumar Ghosh, Jordan Tang

β-Secretase continues to be an attractive drug discovery target for the therapeutic intervention of Alzheimer's disease (AD). This enzyme plays a critical role in the production of neurotoxic β-amyloid (Aβ) peptides in the brain. Over the years, extensive research efforts have led …

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