ER Bleecker

Leveraging Disease Relevant Transcriptomes From TOPMed LTRC Improves Polygenic Transcriptome Risk Prediction for COPD

Xin Hu, Katherine Callaway Kim, Li Wang, Chachrit Khunsriraksakul et autres

Abstract RATIONALE: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of mortality worldwide. We previously published the polygenic transcriptome risk score (PTRS) which uses the cumulative effect of predicted gene expression to construct genetic predictors for complex diseases, and we demonstrated …

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Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program

Nitin Gupta, Stephen S. Rich, Xin Hu, B.E Cade et autres

While polygenic risk scores (PRSs) enable early identification of genetic risk for chronic obstructive pulmonary disease (COPD), predictive performance is limited when the discovery and target populations are not well matched. Hypothesizing that the biological mechanisms of disease are shared across ancestry …

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Exploring pleiotropy using principal components.

Carl D. Langefeld, Deborah A. Meyers, Jianfeng Xu, ER Bleecker et autres

A standard multivariate principal components (PCs) method was utilized to identify clusters of variables that may be controlled by a common gene or genes (pleiotropy). Heritability estimates were obtained and linkage analyses performed on six individual traits (total cholesterol (Chol), high and …

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Dupilumab Efficacy in Patients with Moderate-to-Severe Type 2 Asthma With and Without Elevated Blood Neutrophils

ER Bleecker, Reynold A. Panettieri, Njira Lugogo, Jonathan Corren et autres

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Deep Resequencing of the Beta-2 Adrenergic Receptor Gene (ADRB2) in COPD and Asthma Cohorts Identifies Functional Rare Variants

Victor E. Ortega, D. Kim, Wendy C. Moore, Joe Zein et autres

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Patient-Reported Clinical Variables Associated with Significant Air Trapping in Smokers: An Analysis of the SPIROMICS Cohort

S. Putcha, Tian Gu, Susan Murray, Catherine A. Meldrum et autres

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Lung Volumes Differences Across GOLD Stages of COPD in VA Electronic Health Records, COPDGene, and SPIROMICS

Mehrdad Arjomandi, Siyang Zeng, Izabella Mogilnicka, Igor Barjaktarević et autres

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Intermediate (CD14++ CD16+) Monocytes Correlate with Parametric Response Mapping of Functional Small Airways Disease: Spiromics Immunophenotyping Sub-Study

Christine M. Freeman, Jessica P. Brown, M.R. Kady, Valerie R. Stolberg et autres

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Short-term and Maintenance Oral Corticosteroid Use for German Patients with Asthma

Olaf Schmidt, Cassandra Nan, Robert Lindner, Yasemin Ilgin et autres

Introduction: Characterization of regional variation in asthma treatment across Germany will improve understanding of real-world therapy and inform physician education. We aimed to describe regional variation in asthma prevalence and oral corticosteroid (OCS) use in Germany. Methods: We developed a machine learning …

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P144 Regional variation in OCS use for UK patients with asthma: heat map analysis

Andrew Menzies‐Gow, Thomas Haslam, Tamsin Morris, LH Gylvin et autres

Introduction and objectives A better understanding of differences in asthma prevalence between regions will inform disease management and treatment. To examine regional variations in prevalence of severe asthma and severe, uncontrolled asthma, we analyzed pharmacy records from the United Kingdom. Methods Data …

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Pathogenic Primary Ciliary Dyskinesia Pathway Variants Associate with Disease Severity in At-Risk Smokers and COPD Subjects from SPIROMICS

C.E. Brehm, Frank Genese, Chad R. Marion, Xinyu Li et autres

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Efficacy of once-daily tiotropium Respimat® in adults with asthma based on GINA steps 2 – 5

Edward C. Beck, ER Bleecker, Rikke Buhl, Mary Fitzgerald et autres

Introduction: Tiotropium Respimat® is well tolerated and efficacious as add-on therapy to maintenance low-dose ICS to high-dose ICS/LABA in adults with symptomatic asthma. Aims: We examined if these clinical benefits were consistent across groups classified as GINA Steps 2 – 5. Methods: …

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