S K Zhai

Rosmarinic acid modulates microglial Nrf2/HO-1 and NF-κB–NLRP3 signaling in vascular dementia: Multi-omics and experimental evidence

Taotao Jiang, Ting Zheng, Xiaorong Cheng, S K Zhai et autres

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Morroniside maintains mitochondrial homeostasis in microglia and mitigates neuroinflammation in experimental autoimmune encephalomyelitis

S K Zhai, Taotao Jiang, Xiaorong Cheng, X X Li et autres

Microglia-mediated neuroinflammation in the central nervous system is a hallmark of both multiple sclerosis (MS) and the animal model experimental autoimmune encephalomyelitis (EAE). Current immunosuppressive therapies for MS have limited efficacy and notable side effects. This study aimed to investigate mechanisms underlying …

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Morroniside ameliorates experimental autoimmune encephalomyelitis by regulating gut microenvironment, immune balance, and NF-κB neuroinflammatory pathway

Taotao Jiang, S K Zhai, Ting Zheng, Xiaorong Chen et autres

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Traditional Chinese medicine provides candidates for mutiple seclorsis: A review based on the progress of MS and potent treatment medicine

S K Zhai, Yan Chen, Taotao Jiang, Fengjuan Wu et autres

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Morroniside Attenuates Experimental Autoimmune Encephalomyelitis Via Nrf2/Ho-1/P62 Signaling Pathway:A Mechanism of Mitigating Mitochondrial Oxidative Stress and Enhancing Mitophagy to Promote Microglial Anti-Inflammation

Manxia Wang, S K Zhai, Taotao Jiang, Qi Wang et autres

PP-091 Protective effect of caffeic acid phenethyl ester on liver injury model in rats

Shengchun Dang, S K Zhai, Xingzheng Wang, Yuchen Li et autres

The evolution of the immunoglobulin heavy chain variable region (IgV H ) in Leporids: an unusual case of transspecies polymorphism

Pedro J. Esteves, Dennis Lanning, Nuno Ferrand, Katherine L. Knight et autres

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In vitro induction of the expression of multiple IgA isotype genes in rabbit B cells by TGF-beta and IL-2.

H Spieker-Polet, Pi-Chen Yam, Zarema Arbieva, S K Zhai et autres

The rabbit genome has 13 different Calpha genes that are expressed at different levels in mucosal tissues. To analyze the factors involved in the differential expression of these Calpha genes, we cloned and sequenced the promoters of the Ialpha regions that control …

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Transchromosomally derived Ig heavy chains

Katherine L. Knight, M Kingzette, Mary A. Crane, S K Zhai

During an immune response, activated B cells undergo isotype switching and begin to express isotypes other than IgM and IgD. Isotype switching occurs when downstream C gamma, C alpha, or C epsilon genes are rearranged into the S mu chromosomal region, resulting …

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Neonatal VH, D, and JH gene usage in rabbit B lineage cells.

Martha L. Friedman, Chainarong Tunyaplin, S K Zhai, K L Knight

The neonatal antibody repertoire in both mouse and humans differs from that of the adult repertoire in that the neonatal repertoire uses a limited set of JH-proximal VH genes but the adult repertoires use many different VH genes. Rabbits are unusual in …

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VDJ genes in VHa2 allotype-suppressed rabbits. Limited germline VH gene usage and accumulation of somatic mutations in D regions

Jeffery A. Short, P. Sethupathi, S K Zhai, Katherine L. Knight

In this study we investigate the molecular genetic basis for VHa- Ig. Knowing that the expression of VHa allotype Ig is suppressed by neonatal injection of rabbits with anti-VHa allotype antibody, and that the decreased level of VHa allotype Ig, VHa+, in …

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Immunomopharmacological effects of polysaccharides from Acanthopanax senticosus on experimental animals

Mingli Shen, S K Zhai, Haozhi Chen, Guanyu Tu et autres

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