Chengxiang Deng

Reviewer #2 (Public review): Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

Yaying Zhu, Chengxiang Deng, Bo Chen, Jia He et autres

Hepatocytes undergo extensive proliferation to facilitate liver repair after injury, yet early adaptive changes prior to proliferation remain unclear. Here, we report that during early acetaminophen (APAP)-induced liver injury, hepatocytes exhibit transient proliferation suppression, most pronounced in mid-zone hepatocytes due to zonal …

Author response: Differential regulation of hepatic macrophage fate by Chi3l1 in metabolic dysfunction-associated steatotic liver disease

Jia He, Bo Chen, Weiju Lu, Xiong Wang et autres

cn (code pays fourni par la source)

Differential regulation of hepatic macrophage fate by Chi3l1 in metabolic dysfunction-associated steatotic liver disease

Jia He, Bo Chen, Weiju Lu, Xiong Wang et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) progression involves the replacement of protective embryo-derived Kupffer cells (KCs) by inflammatory monocyte-derived macrophages (MoMFs), yet the regulatory mechanisms remain unclear. Here, we identify chitinase 3-like 1 (Chi3l1/YKL-40) as a critical metabolic regulator of hepatic macrophage …

cn (code pays fourni par la source)

Author response: Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD

Jia He, Bo Chen, Weiju Lu, Xiong Wang et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) progression involves the replacement of protective embryo-derived Kupffer cells (KCs) by inflammatory monocyte-derived macrophages (MoMFs), yet the regulatory mechanisms remain unclear. Here, we identify chitinase 3-like 1 (Chi3l1/YKL-40) as a critical metabolic regulator of hepatic macrophage …

Reviewer #3 (Public review): Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

Yaying Zhu, Chengxiang Deng, Bo Chen, Jia He et autres

Hepatocytes undergo extensive proliferation to facilitate liver repair after injury, yet early adaptive changes prior to proliferation remain unclear. Here, we report that during early acetaminophen (APAP)-induced liver injury (AILI), hepatocytes exhibit transient proliferation suppression, most pronounced in mid-zone hepatocytes due to …

Differential regulation of hepatic macrophage fate by Chi3l1 in metabolic dysfunction-associated steatotic liver disease

Jia He, Bo Chen, Xiong Wang, Chengxiang Deng et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) progression involves the replacement of protective embryo-derived Kupffer cells (KCs) by inflammatory monocyte-derived macrophages (MoMFs), yet the regulatory mechanisms remain unclear. Here, we identify chitinase 3-like 1 (Chi3l1/YKL-40) as a critical metabolic regulator of hepatic macrophage …

cn (code pays fourni par la source)

Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD

Jia He, Bo Chen, Xiong Wang, Chengxiang Deng et autres

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) progression involves the replacement of protective embryo-derived Kupffer cells (KCs) by inflammatory monocyte-derived macrophages (MoMFs), yet the regulatory mechanisms remain unclear. Here, we identify chitinase 3-like 1 (Chi3l1/YKL-40) as a critical metabolic regulator of hepatic …

cn (code pays fourni par la source)

Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD

Jia He, Bo Chen, Xiong Wang, Chengxiang Deng et autres

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) progression involves the replacement of protective embryo-derived Kupffer cells (KCs) by inflammatory monocyte-derived macrophages (MoMFs), yet the regulatory mechanisms remain unclear. Here, we identify chitinase 3-like 1 (Chi3l1/YKL-40) as a critical metabolic regulator of hepatic …

cn (code pays fourni par la source)

Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue Specificity

Y. Xiong, D. S. Franklin, V. L. Godfrey, Chengxiang Deng et autres

The presence of two families of seven distinct mammalian cyclin-dependent kinase (CDK) inhibitor genes is thought to mediate the complexity of connecting a variety of cellular processes to the cell cycle control pathway. The distinct pattern of tissue expression of CDK inhibitor …