Wen-Wen Chu

Development and validation of nomograms for personalized risk assessment of ICU-acquired carbapenem-resistant Enterobacterales

Jie-Hao Tai, Yushan Zhang, Yi-Yu Lyu, Wei Tang et autres

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Association between apolipoprotein E gene polymorphisms and the effects of high-intensity interval training on body composition in university students

Hao-Nan Chu, Wen-Wen Chu, Shan-Rong Xu, Yan Liu et autres

Objective This study examined the effects of APOE gene polymorphisms on body composition changes following high-intensity interval training (HIIT) in non-athletic Han Chinese university students from plain regions and identified genetic loci associated with HIIT sensitivity. Methods A total of 236 Han …

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Single Daily versus Multiple-Daily Sputum Cultures for Guiding Antibiotic Therapy in ICU Patients with Pulmonary Infections: A Retrospective Cohort Study

J.-F. Wang, Zhi Liu, Qian-Cheng Xia, Wen-Wen Chu et autres

Background: Effective antibiotic management is crucial for ICU patients with pulmonary infections. However, guidelines are unclear whether the optimal strategy is multiple cultures on the infection onset day or a single daily culture to guide antibiotic therapy. Methods: This study involved 362 …

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Phenotypic and genotypic characterization of colonization and infection with carbapenem-resistant Enterobacteriaceae: A prospective cohort study in China

Yushan Zhang, Wen Huang, Wen-Wen Chu, Min Yang et autres

Objectives A prospective multicenter study was conducted to elucidate the phenotypic and genotypic characteristics of carbapenem-resistant Enterobacteriaceae (CRE) colonization and infection strains. Methods Strains were collected within one year from ten intensive care units (ICUs) in Anhui Province, China. Antimicrobial susceptibility testing …

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Global, regional, and national burden of bacterial carbapenem resistance from 1990 to 2021 and predictions up to 2035

Yushan Zhang, Wen-Wen Chu, Min Cheol Yang, Qiang Zhou et autres

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Genomic characteristics and phylogenetic analyses of colonization and infection with carbapenem-resistant Klebsiella pneumoniae in multicenter intensive care units: a cohort study

Yile Wu, Wen-Wen Chu, Xiaoqian Hu, Ruo-Jie Li et autres

ABSTRACT Carbapenem-resistant Klebsiella pneumoniae ( CRKp ) poses a major threat to global public health. This study aimed to investigate the genomic characteristics and phylogenetic relatedness of colonization and infection with CRKp among intensive care unit (ICU) patients. A total of 61 …

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Association of β2-Microglobulin with Physical Performance in Chinese Hemodialysis Patients with and without Diabetes

Qiu-Nan Zhan, Wen-Wen Chu, Qi Guo, Junli Zhao

Key Points In the patients on hemodialysis, β 2-microglobulin was lower in those with worse physical performance than in those with better physical performance. A significant association of higher β 2-microglobulin was discovered with better physical performance in the patients on hemodialysis …

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Carbapenem-resistant Klebsiella oxytoca transmission linked to preoperative shaving in emergency neurosurgery, tracked by rapid detection via chromogenic medium and whole genome sequencing

Yunlan Jiang, Lili Liu, Zhiping Li, Dan Liu et autres

Objectives This study describes the detection and tracking of emergency neurosurgical cross-transmission infections with carbapenem-resistant Klebsiella oxytoca (CRKO). Methods We conducted an epidemiological investigation and a rapid screening of 66 surveillance samples using the chromogenic selective medium. Two CRKO isolates from infected …

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BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway

Junli Zhao, Lin Zhao, Qiu-Nan Zhan, Miao Liu et autres

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Prevalence and risk factors for colonisation and infection with carbapenem-resistant Enterobacterales in intensive care units: A prospective multicentre study

Yile Wu, Xiaoqian Hu, Dequan Wu, Ruo-Jie Li et autres

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