Ann Philip

Risk factors for catheter-related bloodstream infections in a high-risk cancer patient population

Andrea Haddad, Rita Wilson Dib, Anne‐Marie Chaftari, Ying Jiang et autres

To identify risk factors for catheter-related bloodstream infections (CRBSI) in cancer patients, we compared 200 CRBSI cases to 400 controls. Neutropenia, transplants, multiple catheters, blood products, and basilic/cephalic PICCs increased CRBSI risk, while jugular insertion was protective. Catheter site selection can reduce …

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Prognostic Value of Serum and Bronchoalveolar Lavage Fluid Galactomannan Levels in Invasive Aspergillosis: An 8-Year Experience at a Tertiary Cancer Center

Saliba Wehbe, Anne‐Marie Chaftari, Ray Y Hachem, Hiba Dagher et autres

Background: Invasive aspergillosis (IA) is a life-threatening fungal infection that primarily affects immunocompromised individuals and has high morbidity and mortality rates, necessitating timely diagnosis and treatment. This study aimed to evaluate the prognostic utility of serum and bronchoalveolar lavage (BAL) fluid galactomannan …

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Prognostic Value of Serum and Bronchoalveolar Lavage Fluid Galactomannan Levels in Invasive Aspergillosis: An 8-Year Experience at a Tertiary Cancer Center

Saliba Wehbe, Anne‐Marie Chaftari, Ray Y Hachem, Hiba Dagher et autres

Background: Invasive aspergillosis (IA) is a life-threatening fungal infection that primarily affects immunocompromised individuals and has high morbidity and mortality rates, necessitating timely diagnosis and treatment. This study aimed to evaluate the prognostic utility of serum and bronchoalveolar lavage (BAL) fluid galactomannan …

P-226. Assessing the Risk Factors for Catheter Related Bloodstream Infections (CRBSI) among Cancer Patients with Long Term Central Venous Catheters (LCVC) for Implementing Preventive Interventions

Andrea Haddad, Rita Wilson Dib, Anne‐Marie Chaftari, Ying Jiang et autres

Abstract Background Catheter Related Bloodstream Infection (CRBSI) remains a leading cause of morbidity, mortality, and escalating costs in cancer patients with LCVC despite advancements in medical care and the implementation of BSI bundle. Several risk related studies have been published in cancer …

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Procalcitonin Level Monitoring in Antibiotic De-Escalation and Stewardship Program for Patients with Cancer and Febrile Neutropenia

Hiba Dagher, Anne‐Marie Chaftari, Ray Y Hachem, Ying Jiang et autres

Objective: Serial procalcitonin (PCT) monitoring has been adopted to supplement clinical judgement and help guide antibiotic therapy as part of antimicrobial stewardship programs. PCT levels peak 24 to 48 h after infection onset and decline with infection resolution. We explored the role …

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A randomized non-inferiority study comparing imipenem/cilastatin/relebactam with standard-of-care Gram-negative coverage in cancer patients with febrile neutropenia

Anne‐Marie Chaftari, Hiba Dagher, Ray Y Hachem, Ying Jiang et autres

BACKGROUND: Antibiotic overuse leads to the emergence of antibiotic resistance that threatens immunocompromised cancer patients. Infections caused by MDR Gram-negative pathogens are difficult to treat and associated with high mortality. Hence, empirical therapy with standard-of-care (SOC) antibiotics could be suboptimal in these …

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363. A Phase II Prospective Randomized Study to Assess Imipenem-Relebactam in the Management of Cancer Patients with Febrile Neutropenia

Anne‐Marie Chaftari, Hiba Dagher, Ray Y Hachem, Ying Jiang et autres

Abstract Background The overuse of antibiotics has led to the emergence of antibiotic resistance that poses a significant threat particularly for the immunocompromised cancer patients. Hence, the empiric therapy with standard antibiotic could be suboptimal in these vulnerable patients who often receive …

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859. The Role of Procalcitonin in Antimicrobial De-escalation and Stewardship Program in Febrile Neutropenic Cancer Patients

Hiba Dagher, Anne‐Marie Chaftari, Ray Y Hachem, Ying Jiang et autres

Abstract Background Serial procalcitonin (PCT) measurement has been adopted as an adjunct to clinical judgement to guide antibiotic therapy, prevent antibiotics overuse and endorse antimicrobial stewardship programs. PCT peaks at 24 to 48 hours, and declines with infection resolution. In this prospective …

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A single-institution experience with the pembrolizumab (PEM) Expanded Access Program (EAP).

Karen Mae Perdon, Dae Won Kim, Gener C Balmes, VanAnh Trinh et autres

e20088 Background: PEM is contingently approved in the US to treat patients (pts) with advanced melanoma (MEL) whose disease progressed following ipilimumab (IPI) and a BRAF inhibitor (if BRAFV600-mutated MEL). We report our clinical experience of MEL pts enrolled in the PEM …

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EPISTAXIS: AN EASY AND EFFECTUAL METHOD OF PLUGGING.

Ann Philip