Jeroen M. Jansen

Antibiotic-associated Enterococcus expansion in the gastrointestinal tract precedes infected necrosis in acute necrotizing pancreatitis

Fons F. van den Berg, Hannah S. Pauw, Hester C. Timmerhuis, Marc G. Besselink et autres

Infected pancreatic necrosis complicates 30% of necrotizing pancreatitis cases, with intestinal bacterial translocation as the presumed mechanism. To characterize gastrointestinal microbiota dynamics preceding infection, we performed a predefined subgroup analysis of the POEMA cohort, a prospective multicenter microbiota study across 20 Dutch …

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Identification of robust associations between admission microbiome profiles and complications of acute pancreatitis

Hannah S. Pauw, Hester C. Timmerhuis, Marc G. Besselink, Yama Issa et autres

Objective Patients with acute pancreatitis show reduced gut microbiome diversity and high abundance of pathogenic bacteria compared with healthy subjects. Admission microbiome profiles are increasingly linked to severity, but methodology and study quality hamper interpretation. Our aim was to investigate whether admission …

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Ustekinumab Intravenous Reinduction after Secondary Loss of Response in Patients with Crohn’s Disease

Stefan Schreiber, Scott David Lee, Christien Janneke Van Der Woude, Ignacio Marín‐Jiménez et autres

BACKGROUND: The POWER study (NCT03782376) evaluated efficacy and safety of a single ustekinumab intravenous (IV) reinduction dose versus placebo under continued ustekinumab subcutaneous (SC) treatment in adult patients with moderately to severely active Crohn's disease who demonstrated a secondary loss of response …

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Two-sample fecal immunochemical testing as a tool to avert colonoscopy in symptomatic patients: a prospective multicenter cohort study

Sarah Moen, Pieter H.A. Wisse, Fleur E. Marijnissen, Iris Lansdorp‐Vogelaar et autres

Background: In most colonoscopies performed for bowel symptoms, no significant lesions are found. To decrease the number of unnecessary colonoscopies, we evaluated the performance of two-sample fecal immunochemical testing (FIT) in ruling out significant lesions. Methods: Symptomatic patients referred for colonoscopy were …

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Reducing outpatient visits for FIT-positive participants of colorectal cancer screening programs with home-based digital counselling

Fleur E. Marijnissen, Elyse E. Rijnders, Merel M. Tielemans, Desirée van Noord et autres

Digital counselling can alleviate the burden on healthcare systems and patients. While it has been evaluated as a supplement to standard care or a substitute for follow-up visits, its use for initial triaging and counselling remains unstudied. We developed a Digital Intake …

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Su1849: LONG-TERM OUTCOMES OF EXTENDED VERSUS CONVENTIONAL ADALIMUMAB DOSE INTERVAL FOR PATIENTS WITH CROHN’S DISEASE IN STABLE REMISSION: 3-YEAR FOLLOW-UP OF THE RANDOMIZED CONTROLLED LADI TRIAL

Lisa M. van Lierop, Fenna A. R. Jansen, Nathan den Broeder, Dirk J. de Jong et autres

606: HYPERBARIC OXYGEN THERAPY DOWNSTAGES REFRACTORY PERIANAL FISTULIZING CROHN'S DISEASE AND ALLOWS FOR SURGICAL CLOSURE

Lieven Mulders, Kim Johanna Beek, Marte A. J. Becker, Pim J. Koelink et autres

Appendicectomy plus standard medical therapy versus standard medical therapy alone for maintenance of remission in ulcerative colitis (ACCURE): a pragmatic, open-label, international, randomised trial

Yaïr I. Z. Acherman, Naila Arebi, Elizabeth Arthurs, Willem A. Bemelman et autres

BACKGROUND: The appendix might have an immunomodulatory role in ulcerative colitis. Appendicectomy has been suggested as a potentially therapeutic intervention to maintain remission in ulcerative colitis. We aimed to evaluate the clinical effectiveness of laparoscopic appendicectomy in maintaining remission in patients with …

Do we need to re-evaluate the role of fine-needle aspiration in infected necrotizing pancreatitis in the post-POINTER era?

Hannah S. Pauw, Astrid Beij, HC Timmerhuis, Lotte Boxhoorn et autres

Aims Infected necrotizing pancreatitis is increasingly managed with delayed invasive intervention and conservative antibiotic therapy. In this context, fine needle aspiration (FNA) could play a crucial role by facilitating targeted, culture-based antimicrobial treatment. Our study aimed to assess the clinical value of …

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P0860 Long-term outcomes of extended versus conventional adalimumab dose interval for patients with Crohn’s disease in stable remission: 3-year follow-up of the randomized controlled LADI trial

Martine Devillers, Lisa M.A. van Lierop, Robbart van Linschoten, Fenna M. Jansen et autres

Abstract Background In the randomized controlled LADI trial, a subset of patients with Crohn’s disease (CD) maintained clinical remission following extension of the adalimumab dose interval (1). The aim of this study was to assess long-term clinical outcomes for trial participants who …

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Cost‐effectiveness and cost‐utility of optimized mercaptopurine treatment versus placebo in ulcerative colitis patients: The randomized controlled OPTIC trial

Mark Löwenberg, Marit van Barreveld, Adriaan Volkers, Sara van Gennep et autres

BACKGROUND AND AIMS: We assessed the cost-effectiveness and cost-utility of therapeutic drug monitoring (TDM)-guided mercaptopurine treatment compared with placebo in ulcerative colitis (UC) patients failing 5-aminosalicylates. METHODS: Data were gathered alongside the randomized controlled OPTIC trial (EudraCT: 2015-005260-41). The evaluation was performed …

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Sa1760 RAPID SYMPTOMATIC IMPROVEMENT WITH SUBCUTANEOUS INFLIXIMAB INDUCTION TREATMENT FOR PATIENTS WITH MODERATE TO SEVERE CROHN'S DISEASE: FIRST RESULTS FROM THE DIRECT-CD STUDY

Suzanne I. Anjie, Bindia Jharap, Jeroen M. Jansen, Wout Mares et autres