Rolf‐Hasso Bödeker

Impact of Parallel Topical Treatment with Nadifloxacin and Adapalene on Acne Vulgaris Severity and Quality of Life: A Prospective, Uncontrolled, Multicentric, Noninterventional Study

Claudia Neumeister, Rolf‐Hasso Bödeker, Ulrich Schwantes, Claudia Borelli

INTRODUCTION: Daily parallel application of adapalene and nadifloxacin has been determined to be effective and well tolerated in patients with acne vulgaris in randomized, controlled clinical studies. Here, the authors report the results from a large, prospective, uncontrolled, multicentric, noninterventional study under …

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Activity of nadifloxacin and three other antimicrobial agents against Cutibacterium acnes isolated from patients with acne vulgaris

Pietro Nenoff, DONALD A. KOCH, Carsten Krüger, Claudia Neumeister et autres

results of a randomized placebo-controlled trial.

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Enzyme Activity of 3ß-HSD and 11ß-HSD as Important Indicators of Steroid Bio-Synthesis and Inactivation in Preterm Infants

Jan de Laffolie, Michaela F. Hartmann, Stefan A. Wudy, Birgit Kampschulte et autres

Background: The fetus lacks 3ß-hydroxysteroiddehydrogenase (3ß-HSD) activity until the last trimenon (requiring placental progesterone) and active cortisol concentration is regulated by synthesis through 11ß-hydroxylase and inactivation by 11ß-hydroxysteroiddehydrogenase (11ß-HSD).In this study we estimate enzyme activity of 3ß-HSD and 11ß-HSD in preterm infants.Method: …

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Anticholinergic burden and comorbidities in patients attending treatment with trospium chloride for overactive bladder in a real-life setting: results of a prospective non-interventional study

Andriy Ivchenko, Rolf‐Hasso Bödeker, Claudia Neumeister, Andreas Wiedemann

BACKGROUND: Elderly people are representative for the patients most likely to be treated with anticholinergics for overactive bladder (OAB). They often receive further drugs with anticholinergic properties for concomitant conditions. This increases the risk for side effects, including central nervous system disorders. …

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Vom Scheitern einer Studie in Maßregelvollzugskrankenhäusern

Peer Briken, Jürgen Müller, Wolfgang Berner, Rolf‐Hasso Bödeker et autres

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Vom Scheitern einer Studie in Maßregelvollzugskrankenhäusern: Klinische Prüfung zum additiven Effekt von Triptorelin auf die Wirksamkeit von Psychotherapie

Peer Briken, Jürgen Müller, Wolfgang Berner, Rolf‐Hasso Bödeker et autres

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Rupatadine in Established Treatment Schemes Improves Chronic Spontaneous Urticaria Symptoms and Patients’ Quality of Life: a Prospective, Non-interventional Trial

Martin Metz, Karsten Weller, Claudia Neumeister, Iñaki Izquierdo et autres

Chronic spontaneous urticaria (CSU) is a common and hard to treat condition associated with a substantial negative impact on patients’ quality of life (QoL). Clinical studies have shown that rupatadine is effective and safe in the treatment of CSU, but data from …

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Estimation of legal age using calcification stages of third molars in living individuals

Philipp Streckbein, Isabelle Reichert, Marcel A. Verhoff, Rolf‐Hasso Bödeker et autres

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Exploring effects of a natural combination medicine on exercise‐induced inflammatory immune response: A double‐blind RCT

Christian Pilat, Torsten Frech, Achim Wagner, Karsten Krüger et autres

Traumeel (Tr14) is a natural, combination drug, which has been shown to modulate inflammation at the cytokine level. This study aimed to investigate potential effects of Tr14 on the exercise-induced immune response. In a double-blind, randomized, controlled trial, healthy, untrained male subjects …

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Reduction in Cortisol Inactivation is Part of the Adrenal Stress Response to Cardiac and Noncardiac Pediatric Surgery: A Prospective Study Using Gas Chromatography-Mass Spectrometry Analysis

Matthias Heckmann, Claudia H. d’Uscio, Harry A. Steckel, Christoph Neuhaeuser et autres

We examined the hypothesis that major cardiac surgery triggers a more intense adrenal stress response than less intensive noncardiac surgery, which then alters cortisol inactivation. Urinary excretion rates of glucocorticoid metabolites were determined before and after surgery using gas chromatography-mass spectrometry in …

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Effect of recirculation on carbon dioxide removal and patient paCO2 during veno-venous extracorporeal membrane oxygenation in adults - preliminary results of an observational clinical trial

Johannes Gehron, Dirk Bandorski, A. Villanueva, Rolf‐Hasso Bödeker et autres

Objectives: Recirculation is a multifactorial event during veno-venous ECMO which results in a variable fraction of oxygenated blood flowing back into the ECMO system due to the proximity of the draining and the delivering cannula. It is thought to result in a …

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FADD Is Upregulated in Relapsing Remitting Multiple Sclerosis

Reinhard Reuß, Marta Mistarz, Andreas Mirau, Jörg Kraus et autres

Objective: To elucidate the role of tumor necrosis factor (TNF) receptor signal transduction in multiple sclerosis (MS). Methods: We performed a cross-sectional analysis of the gene expression of TNF receptor-associated death domain protein (TRADD) and Fas-associated death domain protein (FADD) in peripheral …

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