Yuxi Wen

DASH Diet, Dietary Nitrate, and Nitric Oxide Bioavailability: Implications for Endothelial Dysfunction and Hypertension in Older Adults

Ruhui Zhong, Yuxin Guo, Xinyi You, Junjie Fu et autres

Hypertension in the elderly is closely associated with vascular aging, characterized by endothelial dysfunction (ED) and a progressive decline in nitric oxide (NO) bioavailability. Age-related dysfunction of endothelial nitric oxide synthase (eNOS), compounded by increased oxidative stress, creates a vicious cycle of …

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Food-derived resveratrol confers multigenerational host defense against PA14 via p38 MAPK and DAF-16 signaling in C. elegans

Yuxi Wen, Shuo Shan, Junjie Fu, Jingyue Yao et autres

PA14 infection model, resveratrol significantly improved host survival, with 0.5 mM showing the strongest protective effect. This concentration also enhanced body length, locomotion, and lifespan without causing developmental delay. Fluorescence analysis suggested that resveratrol improved lysosomal and mitochondrial homeostasis and reduced infection-associated …

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Synergistic inhibition of hepatocarcinogenesis by green alga Ulva lactuca polysaccharide and 5-fluorouracil targeted SERPINH1

Wei Liao, Shuo Shan, Jingxiang Xu, Zhengxin Chen et autres

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An orally available 4 ' -fluorouridine prodrug inhibits SFTSV and LCMV infection

Xiaoqin Jian, Tianwen Hu, Huan Xu, Yuxi Wen et autres

ABSTRACT Bunyaviruses, a subset of segmented negative-sense RNA viruses, include pathogenic species capable of zoonotic transmission to humans via arthropod vectors and rodent hosts. Pathogenic bunyavirus infections can cause severe hemorrhagic fevers and other life-threatening diseases, posing threats to human health and …

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Ulvan derived from Ulva lactuca suppresses hepatocellular carcinoma cell proliferation through miR-542-3p-mediated downregulation of SLC35F6

Yinghui Qiu, Jingxiang Xu, Wei Liao, Shuxin Yang et autres

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Effects of Octacosanol Isolated from Moringa oleifera Leaves on Inhibiting the Activity of Pancreatic Lipase

Xiaoying Dong, Yuxi Wen, Qing Nie, Shuo Shan et autres

Moringa oleifera Lam., a perennial species of the Moringaceae family, is esteemed for its multifaceted nutritional, medicinal, and economic properties. M. oleifera leaves are abundant in bioactive compounds with potential health benefits, yet existing structural and functional studies of these bioactives remain …

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Structural characterization and fermentation of a novel Moringa oleifera leaves polysaccharide with hypoglycemic effects

Yuxi Wen, Yang Zhou, Jie Xu, Qi Yao Cui et autres

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Beneficial effects of seaweed-derived active substances on immunoregulatory function

Ruoxin Chen, Yuxi Wen, Nan Jia

Seaweed polysaccharides are among the most important marine plant resources currently being developed, and their immunomodulatory activity has received widespread attention. However, there is still a paucity of the latest summary of the in-depth immune mechanisms of these seaweed polysaccharides. Therefore, in …

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Green algal polysaccharides and derivatives as potential therapeutics for metabolic diseases

Zhengxin Chen, Jiahui Wen, Yuxi Wen, Yuning Liu et autres

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Prospects of phycoerythrin: Structural features, antioxidation and applications in food

Yuxi Wen, Shuo Shan, Fangting Ye, Wei Liao et autres

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Human milk oligosaccharides in preventing food allergy: A review through gut microbiota and immune regulation

Yihan Chen, Yuxi Wen, Runfan Zhao, Yingying Zhu et autres

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Marine algae‐derived characterized bioactive compounds as therapy for cancer: A review on their classification, mechanism of action, and future perspectives

Wei Liao, Yaobin Chen, Shuo Shan, Zhengxin Chen et autres

In 2022, there were around 20 million new cases and over 9.7 million cancer-related deaths worldwide. An increasing number of metabolites with anticancer activity in algae had been isolated and identified, which were promising candidates for cancer therapy. Red algae are well-known …

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