Antoon J. M. Janssen

Cytoskeletal control in adult microglia is essential to restore neurodevelopmental synaptic and cognitive deficits

Sofie Kessels, Chloë Trippaers, Melanie Mertens, Ibrahim Hamad et autres

Synaptic dysfunction is a hallmark of neurodevelopmental disorders (NDDs), often linked to genes involved in cytoskeletal regulation. While the role of these genes has been extensively studied in neurons, microglial functions such as phagocytosis are also dependent on cytoskeletal dynamics. We demonstrate …

be, us, nl, ca (code pays fourni par la source)

APOE deficiency inhibits amyloid-facilitated (A) tau pathology (T) and neurodegeneration (N), halting progressive ATN pathology in a preclinical model

Sarah Vanherle, Antoon J. M. Janssen, Manuel Gutiérrez de Ravé, Bieke Janssen et autres

In AD, amyloid pathology (A) precedes progressive development of tau pathology (T) and neurodegeneration (N), with the latter (T/N) processes associated with symptom progression. Recent anti-amyloid beta (Aβ) clinical trials raise hope but indicate the need for multi-targeted therapies, to effectively halt …

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Dataset for 'How brands highlight country of origin in magazine advertising: A content analysis'

Jos Hornikx, J. van den Heuvel, W.F.J. van Meurs, Antoon J. M. Janssen

Dataset for content analysis published in "Hornikx, J., Meurs, F. van, Janssen, A., & Heuvel, J. van den (2020). How brands highlight country of origin in magazine advertising: A content analysis. Journal of Global Marketing, 33 (1), 34-45." *Abstract (taken from publication) …

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The effectiveness of adapting advertising appeals to cultural values: an experimental and meta-analytical approach

Antoon J. M. Janssen

Measurement of Totally Activated Pyruvate Dehydrogenase Complex Activity in Human Muscle: Evaluation of a Useful Assay

Wolfgang Sperl, J.M.F. Trijbels, W. Ruitenbeek, H.L.J.M. van Laack et autres

A sensitive radiochemical method for the determination of the pyruvate dehydrogenase complex (PDHC) activity in skeletal muscle tissue, based on the decarboxylation of [1-14C]-pyruvate to 14CO2, is described. Measurements can be carried out either in muscle homogenate or in 600-g supernatant, both …

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Motor performance of very preterm and dysmature infants in the multi-ethnic society of Suriname

Maria JAJ Fleurkens-Peeters, Antoon J. M. Janssen, Maria W. G. Nijhuis–van der Sanden, Wilco C. W. R. Zijlmans

Welcome to Annals of Global Health,Annals of Global Health is a peer-reviewed, fully open access, online journal dedicated to publishing high quality articles dedicated to all aspects of global health. The journal's mission is to advance global health, promote research, and foster …

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Cue-shoe dans la maladie de Parkinson : un seul pas du freezing vers la liberté

M.U. Ferraye, C. Stummer, M. van Helvert, Antoon J. M. Janssen et autres

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Tissue specific metabolic consequences of isolated mitochondrial complex I deficiency in mice

Ganesh R. Manjeri, Suzanne Roelofs, Antoon J. M. Janssen, Lionel Blanchet et autres

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Prenatal exposure to moderate doses of X-rays induces cognitive dysfunction in adult mice

Tine Verreet, Roel Quintens, A. Michaux, Antoon J. M. Janssen et autres

Impaired ubiquitin‐proteasome‐mediated PGC ‐1α protein turnover and induced mitochondrial biogenesis secondary to complex‐ I deficiency

Murtada H. Farhoud, Leo G.J. Nijtmans, Ronald J. A. Wanders, Hans J. C. T. Wessels et autres

Most eukaryotic cells depend on mitochondrial OXidative PHOSphorylation (OXPHOS) in their ATP supply. The cellular consequences of OXPHOS defects and the pathophysiological mechanisms in related disorders are incompletely understood. Using a quantitative proteomics approach we provide evidence that a genetic defect of …

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Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome

Bart W. Smits, Lambert van den Heuvel, Hans Knoop, Benno Küsters et autres

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47 Measurement of mitochondrial oxygen consumption using a fluorescence-based oxygen-sensitive probe: Application to mitochondrial medicine

An I. Jonckheere, Merei Huigsloot, Antoon J. M. Janssen, Antonia Kappen et autres

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