Xiaoke Jiang

Latent profiles of self-management behavior and associated factors among Chinese patients with ulcerative colitis

Man Yang, Huiying An, Lei Lei, Yan Chen et autres

Background Ulcerative colitis (UC) poses a growing clinical and socioeconomic burden in China. Effective self-management is critical for long-term disease control, yet significant heterogeneity exists in self-management behavior (SMB) among patients. This study aimed to identify latent profiles of SMB and examine …

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A comparative analysis of three psychological challenge assessment tools for predicting breastfeeding outcome at six months postpartum

Xiaoke Jiang, Weiwei Liang, Yiwen Liang, Ruoxin Liu et autres

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Factors Influencing Occupational Grief Among Pediatric Emergency and Intensive Care Unit Nurses in South China: A Cross‐Sectional Study

Yongqi Liang, Xiaoke Jiang, Yue Peng, Li Sun et autres

AIM: This study aimed to assess the level of occupational grief among pediatric emergency and intensive care unit nurses and identify the factors influencing it. DESIGN: Descriptive cross-sectional study. METHODS: Conducted from March to May 2024, the study included 265 pediatric nurses …

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Why Emphasize Early Postpartum Pumping? The Critical Window for Coming to Volume in Pump-Dependent Mothers and Its Predictive Value for Feeding Method at Preterm Infants’ Discharge

Yongqi Liang, Xiaoke Jiang, Li Yan Sun, Kuiyan Yang et autres

Objectives: Mothers of preterm infants who experience mother–infant separation frequently face increased challenges with lactation. This study aims to analyze the critical window for coming to volume (CTV) and its associated risk factors in pump-dependent mothers and to investigate the predictive value …

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Skin microbiome influences the progression of cutaneous squamous cell carcinoma through the immune system

Zijian Zhang, Lili Liang, Xiaoke Jiang, Siying Li et autres

Cutaneous squamous cell carcinoma (cSCC) is a type of skin tumor that develops in the epithelial cells. This disease has the second highest incidence of human skin cancers, with a high metastatic rate. While ultraviolet radiation significantly contributes to the genomic changes …

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Umbilical cord mesenchymal stem cells in ulcerative colitis treatment: efficacy and possible mechanisms

Xiaoke Jiang, Xiaoying Luo, Yangqiu Bai, Hui Ding et autres

BACKGROUND: Mesenchymal stem cells (MSCs) possess powerful immunomodulatory ability. This study aimed to assess the efficacy and safety of human umbilical cord-derived mesenchymal stem cells (UMSCs) in patients with ulcerative colitis (UC) and to explore the potential mechanisms. METHODS: per kg. The …

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Nucleophagic Degradation of Progerin Ameliorates Defenestration in Liver Sinusoidal Endothelium Due to SIRT1-Mediated Deacetylation of Nuclear LC3

Yangqiu Bai, Jinying Liu, Xiaoke Jiang, Xiuling Li et autres

Progerin, a permanently farnesylated prelamin A protein in cell nuclei, is potentially implicated in the defenestration of liver sinusoidal endothelial cells (LSECs) and liver fibrogenesis. Autophagy regulates the degradation of nuclear components, called nucleophagy, in response to damage. However, little is known …

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Sirtuin 1 ameliorates defenestration in hepatic sinusoidal endothelial cells during liver fibrosis via inhibiting stress‐induced premature senescence

Xiaoying Luo, Yangqiu Bai, Shuli He, Suofeng Sun et autres

Abstract Objective Premature senescence is related to progerin and involves in endothelial dysfunction and liver diseases. Activating sirtuin 1 (SIRT1) ameliorates liver fibrosis. However, the mechanisms of premature senescence in defenestration of hepatic sinusoidal endothelial cells (HSECs) and how SIRT1 affects HSECs …

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SIRT1 ameliorates premature senescence-induced defenestration in hepatic sinusoidal endothelial cell

Xiaoying Luo, Yangqiu Bai, Shuli He, Xiaoke Jiang et autres

Abstract Premature senescence, linked to progerin, involves in endothelial dysfunction and liver diseases. Activating sirtuin 1 (SIRT1) ameliorates liver fibrosis. However, the potential mechanisms of premature senescence in defenestration in hepatic sinusoidal endothelial cells (HSECs) and how SIRT1 affects fenestrae remains elusive. …

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Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53–progerin interaction

Xiaoying Luo, Xiaoke Jiang, Jun Li, Yangqiu Bai et autres

Abstract Stress-induced premature senescence (SIPS), a state of cell growth arrest due to various stimuli, is implicated in the pathogeneses of hepatic fibrogenesis. Progerin, a permanently farnesylated mutant lamin A protein, likely leads to premature senescence to influent liver diseases. The previous …

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