Zijian Zhang

Mitochondrial ‘Attack-and-Trap’ strategy potentiates cGAS-STING signaling to stimulate durable antitumor immunity against glioblastoma

Zijian Zhang, Min Zhuang, Han Li, Chuanshi He et autres

Glioblastoma (GBM) recurrence, driven by therapeutic resistance and diffuse infiltration, remains a critical clinical challenge, fundamentally sustained by a mitochondrial metabolic addiction. To leverage this, we developed a biomimetic nanoplatform (HM-NPs@CM) camouflaged with cancer cell-mitochondria hybrid membranes. This ensures efficient blood-brain barrier …

cn (code pays fourni par la source)

Neurohormonal-Immune Dysregulation in Rosacea: Emerging Perspectives from the Skin-Gut-Brain Axis

Lei Shi, Siying Li, Xiaodong Yao, Zijian Zhang et autres

Rosacea is a chronic inflammatory skin disease with a global prevalence of approximately 5.1%. Existing evidence suggests that its pathogenesis may be associated with dysregulation of the neuro-hormone-immune network within the skin-gut-brain axis framework. This review summarizes the potential roles of stress …

cn (code pays fourni par la source)

Recent Advances in Novel Drug Delivery Systems for the Management of Cutaneous Squamous Cell Carcinoma

Xiaoyi Fu, Zijian Zhang, Qinyi Dong, Siying Li et autres

Xiaoyi Fu,1 Zijian Zhang,1 Qinyi Dong,1 Siying Li,2 Xinman Wang,2 Han Zhang,2 Jiahao Bai,2 Huiyan Han,2 Lei Shi,2 Kaili Zheng,2 Lili Liang2,3 1The Third Clinical College, Shanxi University of Chinese Medicine, Taiyuan, Shanxi, People’s Republic of China; 2Department of Cosmetic and Plastic …

cn (code pays fourni par la source)

Injury-Induced Epithelial Spp1 Engages Cd44 to Promote Neutrophil Recruitment and Exacerbate Acute Kidney Injury

Jiayu Wang, Xin Zheng, Zijian Zhang, Z H Zhao et autres

Background: Acute kidney injury (AKI) severely impairs renal function. In early AKI, tubular cells release damage-associated molecular patterns (DAMPs) that induce neutrophil recruitment. Infiltrating neutrophils can exacerbate kidney injury through degranulation or formation of neutrophil extracellular traps (NETs), but the specific DAMPs …

cn (code pays fourni par la source)

Mechanisms of immunotherapy in cutaneous squamous cell carcinoma in the tumor microenvironment

Zijian Zhang, Siying Li, Lili Liang

Cutaneous squamous cell carcinoma (cSCC) is a common cutaneous malignant tumor, with its development and progression closely linked to immune dysregulation within the tumor microenvironment (TME). This review highlights cSCC-specific TME features-such as UV-induced mutational burden and the immunosuppressive effects observed in …

cn (code pays fourni par la source)

Z-scheme TiO2@CeO2 nanozyme/sonodynamic combination therapy for breast cancer by immunomodulation of tumor microenvironment

Renyu Liu, Wei Wang, Chengcheng Zhang, Liangfang Shen et autres

cn (code pays fourni par la source)

Distinct Lung Adenocarcinoma-Associated Microbiota Are Associated with Inflammatory Immune Landscapes and Tumor Cell Proliferation via LCIIAR–ISG15 Regulatory Networks

Zijian Zhang

Introduction: Emerging research emphasizes the critical role of local microbiota in shaping the tumor microenvironment (TME) and influencing cancer progression. Lung adenocarcinoma (LUAD) is distinguished by unique bacterial communities that appear to regulate immune responses, gene expression, and patient outcomes. Methods: We …

cn (code pays fourni par la source)

Skin microbiome influences the progression of cutaneous squamous cell carcinoma through the immune system

Zijian Zhang, Lili Liang, Xiaoke Jiang, Siying Li et autres

Cutaneous squamous cell carcinoma (cSCC) is a type of skin tumor that develops in the epithelial cells. This disease has the second highest incidence of human skin cancers, with a high metastatic rate. While ultraviolet radiation significantly contributes to the genomic changes …

cn (code pays fourni par la source)

Comparative Study on the Effects of Selenium-Enriched Yeasts with Different Selenomethionine Contents on Gut Microbiota and Metabolites

Zijian Zhang, Li Na Zhu, Hongtao Zhang, Dan Yu et autres

Selenium is an essential trace element for human health, but it mainly exists in an inorganic form that cannot be directly absorbed by the body. Brewer’s yeast efficiently converts inorganic selenium into bioavailable organic selenium, making selenium-enriched yeast highly significant for human …

cn (code pays fourni par la source)

A tetrahedral DNA nanoplatform with ultrasound-triggered biomimetic nanocarriers for targeted siMCM2 delivery and reversal of imatinib resistance in gastrointestinal stromal tumors

Li Han, Quan Dai, Chuanshi He, Jinshun Xu et autres

• MCM2 identified as a novel target to overcome imatinib resistance in GISTs. • Biomimetic TMB@TDN-iRGD-siMCM2 platform enhances tumor targeting and drug stability. • Ultrasound-mediated system significantly improves imatinib sensitivity in GISTs. • In vitro and in vivo models show robust tumor …

cn (code pays fourni par la source)

The Study of Chemical Constituents and Metabolite Profiles of Chitong Xiaoyanling Granules in Normal and Periodontitis Model Rats Based on Ultra‐High‐Performance Liquid Chromatography‐Quadrupole Time‐of‐Flight‐Tandem Mass Spectrometry Analysis

Jieru Zhang, Zijian Zhang, Menghua Yang, Wanwan Zhang et autres

Periodontitis is a chronic inflammation of the periodontal support tissues. The typical symptoms of periodontitis are inflammation and alveolar bone resorption. Chitong Xiaoyanling Granules (CXG) is composed of 10 Chinese herbs, which have the efficacy of dispersing wind, clearing heat, cooling blood, …

cn (code pays fourni par la source)

Multimodal targeting chimeras enable integrated immunotherapy leveraging tumor-immune microenvironment

Shenyi Yin, Zijian Zhang, Ying Yu, Haoming Fang et autres

cn, Éthiopie (code pays fourni par la source)