Izabella Henc

Autoantibodies, C-reactive protein, erythrocyte sedimentation rate and serum cytokine profiling in monitoring of early treatment

Edyta Brzustewicz, Izabella Henc, Agnieszka Daca, Maria Szarecka et autres

INTRODUCTION: Currently used clinical scale and laboratory markers to monitor patients with early rheumatoid arthritis (RA) seem to be not sufficient. It has been demonstrated that disease- related cytokines may be elevated very early in RA development and cytokines are considered as …

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Naturally occurring xanthone and benzophenone derivatives exert significant anti-proliferative and proapoptotic effects in vitro on synovial fibroblasts and macrophages from rheumatoid arthritis patients

Izabella Henc, Adam Kokotkiewicz, Piotr Łuczkiewicz, Ewa Bryl et autres

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Influence of oxygen concentration on T cell proliferation and susceptibility to apoptosis in healthy men and women

Agnieszka Waskowska, Katarzyna Aleksandra Lisowska, Agnieszka Daca, Izabella Henc et autres

INTRODUCTION: Much of what we know about the functioning of human T lymphocytes is based on the experiments carried out in atmospheric oxygen (O₂) concentrations, which are significantly higher than those maintained in blood. Interestingly, the gender differences in the activity of …

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Roles of calpain-calpastatin system (CCS) in human T cell activation

Anna Mikosik, Aleksandra Jasiulewicz, Agnieszka Daca, Izabella Henc et autres

// Anna Mikosik 1 , Aleksandra Jasiulewicz 1 , Agnieszka Daca 2 , Izabella Henc 2 , Joanna E. Frąckowiak 1 , Katarzyna Ruckemann-Dziurdzińska 2 , Jerzy Foerster 3 , Aurelie Le Page 4 , Ewa Bryl 2 , Tamas Fulop 4 …

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Increased μ-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis

Anna Mikosik, Izabella Henc, Katarzyna Rückemann-Dziurdzińska, Joanna E. Frąckowiak et autres

Childhood acute lymphoblastic leukemia (ALL) blasts are characterized by inhibited apoptosis promoting fast disease progress. It is known that in chronic lymphocytic and acute myeloid leukemias the reduced apoptosis is strongly related with the activity of calpain-calpastatin system (CCS) composed of cytoplasmic …

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The in vitro modulatory effect of TNFα on the mRNA expression and protein levels of zinc finger protein ZNF334 in CD4+lymphocytes of healthy people

Izabella Henc, Monika Soroczyńska‐Cybula, Ewa Bryl, Jacek Maciej Witkowski

We have shown before that the expression of ZNF334 gene, coding for a newly described zinc finger protein of as yet unknown function, is extremely reduced in CD4(+) lymphocytes of rheumatoid arthritis (RA) patients regardless of their age, and thus can be …

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Chemokiny jako ważne mediatory stanu zapalnego

Izabella Henc, Ewa Bryl

Chemokiny są kluczem do zrozumienia faktu, jak organizm radzi sobie z czyhającymi na niego zagrozeniami. Te male bialka są istotne w aktywacji i migracji komorek ukladu odpornościowego do miejsc, w ktorych toczy sie proces zapalny. Chemokina aktywuje odpowiedź komorkową poprzez związanie sie …