Emily E. Smith

Adults With Down Syndrome Present Lower Fat-free Mass Density: A 4-compartment Model Approach

Emily E. Smith, Ronald L. Snarr, Justo Perez, Ayush Mehra et autres

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Modeling the Aging Human Lung: Generation of a Senescent Human Lung Organoid Culture System

Mohit Aspal, Natalie Pushlar, Melina Melameka, Rachael N. McVicar et autres

Introduction: The aging lung enters into a state of irreversible cellular growth arrest characterized by senescence. While senescence is beneficial in preventing oncogenic cell proliferation, it becomes detrimental when persistent, promoting chronic inflammation and fibrosis through the senescence-associated secretory phenotype (SASP). Such …

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Modeling patient-specific adenocarcinoma as spheroids enhances the authenticity of cancer hallmarks and therapeutic susceptibility

Rachael N. McVicar, Darren 'Ben' Finlay, Rabi Murad, Kristiina Vuori et autres

Introduction: To help understand and develop treatments for cancer, it is important to have patient-specific, reliable and physiologically-relevant human culture models. Cells from solid tumors have traditionally been grown in 2-dimensional (2D) monolayers, however, it is known that cancer cells can self-organize …

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iPSC-Derived Epithelial, Mesenchymal, Endothelial, and Immune Cell Co-Culture to Model Airway Barrier Integrity in Lung Health and Disease

Rachael N. McVicar, Emily E. Smith, Melina Melameka, Anne Bush et autres

Human lung tissue is composed of an interconnected network of epithelium, mesenchyme, endothelium, and immune cells from the upper airway of the nasopharynx to the smallest alveolar sac. Interactions between these cells are crucial in lung development and disease, acting as a …

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S3815 Macrophage Activation Syndrome Complicated By Fatal Gastrointestinal Bleed

Elizabeth Reznik, Emily E. Smith, Vinita Elizabeth Jacob

Introduction: Macrophage Activation Syndrome (MAS) is a rare, potentially fatal complication of systemic inflammatory disorders that belongs to a group of disorders called Hemophagocytic Lymphohistiocytosis (HLH). It is characterized by inappropriate activation of T lymphocytes and macrophages resulting in fevers, hepatosplenomegaly, pancytopenia, …

Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial

Carl S. Goodyear, Amit K. Patel, Eleanor Barnes, Michelle Kay Willicombe et autres

BACKGROUND: The humoral and T-cell responses to booster COVID-19 vaccine types in multidisease immunocompromised individuals who do not generate adequate antibody responses to two COVID-19 vaccine doses, is not fully understood. The OCTAVE DUO trial aimed to determine the value of third …

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Investigating Airway Surfactant BPIFA1 in the Developing Human Lung

Rachael N. McVicar, Sydney A. Leibel, E.Y. Snyder, Emily E. Smith

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The Effects of Cell-cell Orientation in Modeling the Hallmarks of Lung Cancer In Vitro

Andres Espinoza, Rachael N. McVicar, Darren 'Ben' Finlay, Rabi Murad et autres

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The effects of cell-cell orientation in modeling the hallmarks of lung cancer in vitro

Andres Espinoza, Rachael N. McVicar, Darren 'Ben' Finlay, Rabi Murad et autres

Abstract To better understand and develop treatments for lung cancer, it is important to have reliable and physiologically relevant culture models. Traditional methods of growing lung cancer cells in two- dimensional (2D) monolayers have limitations in mimicking the complex architecture and microenvironment …

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SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

Eleanor Barnes, Carl S. Goodyear, Michelle Kay Willicombe, Charlotte Gaskell et autres

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immune responses and infection outcomes were evaluated in 2,686 patients with varying immune-suppressive disease states after administration of two Coronavirus Disease 2019 (COVID-19) vaccines. Overall, 255 of 2,204 (12%) patients failed to develop anti-spike …

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Correction: HDAC inhibitor AR-42 decreases CD44 expression and sensitizes myeloma cells to lenalidomide

Alessandro Canella, Hector Cordero Nieves, Douglas Weston Sborov, Luciano Cascione et autres

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The Effect of Curative Treatment on Hyperglycemia in Patients With Cushing Syndrome

Justine S. Herndon, Ravinder Jeet Kaur, Mark Romportl, Emily E. Smith et autres

Abstract Context Hyperglycemia is a common complication of Cushing syndrome (CS). Objective We aimed to determine the impact of curative procedure on hyperglycemia and its management in patients with CS. Methods This retrospective longitudinal cohort study took place 2000 to 2019 in …

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