Vinita Elizabeth Jacob

Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis

Baosen Jia, Yuhua Shi, Yourae Hong, Chongbo Yang et autres

Caspase 5 (CASP5) is a member of the inflammatory caspase family of cysteine proteases that is involved in inflammation and cell death1–3. CASP5 shares the highest homology with inflammatory CASP4, but whereas CASP4 is essential for noncanonical inflammasome activation, CASP5 is dispensable4–6, …

us, gb, be (code pays fourni par la source)

Altered Gut Microbiota in Pediatric Quiescent Crohn’s Disease Patients with Iron Deficiency Anemia

Elliott Gordon, Jérémy Goc, Alexander R. Grier, Charlene Thomas et autres

BACKGROUND: Iron deficiency anemia (IDA) is the most common extra-intestinal complication in inflammatory bowel disease (IBD). The persistence of iron deficiency in patients living with quiescent IBD remains poorly understood. Given the extensive body of research linking IBD pathogenesis to microbiome disruptions, …

us (code pays fourni par la source)

S1540 Effectiveness of Combination Biologic and/or Small Molecule Therapies in Inflammatory Bowel Disease: A Single Center Analysis

Jacob K.R. Jamison, Anjile An, Caroline J. Young, Michael J Mintz et autres

Introduction: Despite an increasing variety of treatment options, many inflammatory bowel disease (IBD) patients do not achieve therapy goals. Plateauing efficacy of single-agent regimens is commonly reported even after therapy optimization. This study evaluates the effectiveness of combination regimens including newer agents …

S1539 Safety of Combination Biologic and/or Small Molecule Therapies in Inflammatory Bowel Disease: A Single-Center Analysis

Jacob K.R. Jamison, Anjile An, Caroline J. Young, Michael J Mintz et autres

Introduction: Despite an increasing variety of treatment options, many inflammatory bowel disease (IBD) patients do not achieve therapy goals. Many require hospitalization and high-risk interventions, such as steroids or surgery. This study evaluates the safety of combination regimens including newer agents in …

Host metabolism balances microbial regulation of bile acid signalling

Tae Won, Mohammad Arifuzzaman, Christopher N. Parkhurst, Isabella C. Miranda et autres

us, kr (code pays fourni par la source)

S3815 Macrophage Activation Syndrome Complicated By Fatal Gastrointestinal Bleed

Elizabeth Reznik, Emily E. Smith, Vinita Elizabeth Jacob

Introduction: Macrophage Activation Syndrome (MAS) is a rare, potentially fatal complication of systemic inflammatory disorders that belongs to a group of disorders called Hemophagocytic Lymphohistiocytosis (HLH). It is characterized by inappropriate activation of T lymphocytes and macrophages resulting in fevers, hepatosplenomegaly, pancytopenia, …

CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation

Anees Ahmed, Ann Mary Joseph, Jordan Zhou, Veronika Horn et autres

us, jp, fr (code pays fourni par la source)

Fertility and Pregnancy inInflammatory Bowel Disease

Jeffry Katz, Vinita Elizabeth Jacob

The incidence of inflammatory bowel disease (IBD) appears to be increasing worldwide, even in areas not previously described as having an increased prevalence of the disease. Given the bimodal age distribution of the onset of symptoms, the issue of inflammatory bowel disease …

Fertility and Pregnancy in Inflammatory Bowel Disease

Jeffry Katz, Vinita Elizabeth Jacob

The incidence of inflammatory bowel disease (IBD) appears to be increasing worldwide, even in areas not previously described as having an increased prevalence of the disease. Given the bimodal age distribution of the onset of symptoms, the issue of inflammatory bowel disease …

Methotrexate in the Treatment of Ulcerative Colitis

Ellen Scherl, Vinita Elizabeth Jacob, Brian P. Bosworth, Ryan Urquhart Warren et autres

Methotrexate, a folate antagonist and potent anti-inflammatory agent, is an analog of dihydrofolic acid that inhibits dihydrofolate reductase and folate-dependent enzymes that are pivotal in the synthesis of purines and pyrimidines. 1-3 It is an effective therapy in rheumatoid arthritis, Crohn&s;s disease, …

Mo1857 EFFECTIVENESS AND SAFETY OF COMBINATION BIOLOGIC AND/OR SMALL MOLECULE THERAPIES IN INFLAMMATORY BOWEL DISEASE: A SINGLE-CENTER ANALYSIS OF CONTEMPORARY ADVANCED THERAPIES

Jacob K.R. Jamison, Anjile An, Randy Longman, Vinita Elizabeth Jacob et autres

Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation

Mohammad Arifuzzaman, Tae Hyung Won, Hiroshi Yano, Jazib Uddin et autres

Innate lymphoid cells (ILCs) can promote host defense, chronic inflammation, or tissue protection and are regulated by cytokines and neuropeptides. However, their regulation by diet and microbiota-derived signals remains unclear. We show that an inulin fiber diet promotes Tph1-expressing inflammatory ILC2s (ILC2INFLAM) …

us (code pays fourni par la source)