Xiaobo Zhao

Polygonal nucleic acid frame-accelerated nanomachine with dual recognition sites for sensitive sensing of breast cancer metastasis

Lin Peng, Xi Zhang, Xiaobo Zhao, Qian Dai et autres

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Breast Cancer Burden in BRICS Countries Attributable to Smoking, High Alcohol Use, High Body Mass Index, and Low Physical Activity, 1990–2021: Findings from the Global Burden of Disease 2021 and Mendelian Randomization

Xiao Yan, Chenyi Liao, Shuangqiang Qian, Chen Zhang et autres

Xiao Yan,1,* Chenyi Liao,1,* Shuangqiang Qian,1,* Chen Zhang,2,3 Jiangzhuo Wu,1 Jiang Fang,1 Xiaobo Zhao,1,* Lin Peng1,* 1Department of Thyroid and Breast Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, People’s Republic of China; 2Department of General Surgery, Wusheng County People’s Hospital …

Breast Cancer Burden in BRICS Countries Attributable to Smoking, High Alcohol Use, High Body Mass Index, and Low Physical Activity, 1990–2021: Findings from the Global Burden of Disease 2021 and Mendelian Randomization

Xiao Yan, Chenyi Liao, Shuangqiang Qian, Chen Zhang et autres

Background: Breast cancer remains the leading cause of cancer incidence and mortality among women globally. However, studies that not only compare the population-level burden but also interrogate the underlying causal mechanisms to explain the observed cross-national disparities are lacking. This limits the …

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Platinum-based neoadjuvant chemotherapy in triple-negative breast cancer: An updated systematic review and meta-analysis

Justin J. Wu, Yan Xiao, Fang Jiang, Peng Lin et autres

BACKGROUND: Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that is characterized by its association with shortened survival durations and a heightened likelihood of recurrence. Platinum-based chemotherapy has been demonstrated to increase the rate of pathological complete response …

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Phototheranostic Zinc Porphyrin Nanoparticles Triggered by an 808 nm Laser: NIR-II Fluorescence/Photoacoustic Imaging-Guided Combined Photothermal/Photodynamic/NO Therapy

Hongyu Chen, Xiaobo Zhao, Akbar Halimov, Mingkai Fu et autres

Single-wavelength lasers that trigger intelligently designed multifunctional theranostic nanoplatforms are urgently needed for early cancer diagnosis and imaging-guided therapy. In this study, a novel zinc porphyrin, Por-TR, was fabricated by incorporating thiophene as a donor and introducing electron acceptors on both sides …

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Small particle drug-eluting beads-transarterial chemoembolization combined with targeted therapy in the clinical treatment of unresectable liver cancer

Jing-Song Qi, Peng Zhao, Xiaobo Zhao, Yongli Zhao et autres

BACKGROUND: Liver cancer is a highly malignant tumor with significant clinical impact. Chemotherapy alone often yields suboptimal outcomes in both the short and long term, characterized by high rates of local recurrence and distant metastasis, leading to a poor long-term prognosis. AIM: …

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Pregnancy Outcomes and Associated Factors for Uterine Rupture: A population-based retrospective study

Sheng Biao Wan, Mengnan Yang, Jindan Pei, Xiaobo Zhao et autres

Objective To assess the incidence of uterine rupture, its association with previous uterine surgery and vaginal birth after a caesarean section (VBAC), and the maternal and perinatal implications. Design Population-based retrospective study. Setting Shanghai, China. Participants A total of 209,112 deliveries were …

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Single progesterone receptor-positive phenotype has the similar clinicopathological features and outcome as triple-negative subtype in metastatic breast cancer

Yunbo Luo, Hongyu Pu, Fangwei Li, Shuangqiang Qian et autres

Objective: The same clinicopathological features and prognosis have been reported between single progesterone receptor-positive (sPR-positive) and triple-negative phenotype in early-stage breast cancer, but such similarity has not been studied in metastatic breast cancer (MBC). Therefore, the purpose of this study was to …

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Predictors for histological chorioamnionitis among women with preterm prelabour rupture of membranes after dexamethasone treatment: a retrospective study

Jing Peng, Ying Chen, Sheng Biao Wan, Tianfan Zhou et autres

OBJECTIVE: To investigate reliable biomarkers for predicting histological chorioamnionitis (HCA) in women with preterm prelabour rupture of membranes (PPROM). DESIGN: A retrospective study. SETTING: A maternity care hospital in Shanghai. POPULATION: weeks of gestation. METHODS: Mean values of biomarkers were compared by …

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Association Between Maternal Weight Gain in Different Periods of Pregnancy and the Risk of Venous Thromboembolism: A Retrospective Case–Control Study

Yuelin Wu, Jindan Pei, Lingling Dong, Zheying Zhou et autres

Background: Venous thromboembolism (VTE) remains an important cause of maternal deaths. Little is known about the associations of specific periods of gestational weight gain (GWG) with the category of VTE, pulmonary embolism (PE), or deep venous thrombosis (DVT) with or without PE. …

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Predictors for histological chorioamnionitis among women with preterm premature rupture of membranes after dexamethasone administration：a retrospective study

Jing Peng, Ying Chen, Sheng Biao Wan, Tianfan Zhou et autres

Objective: To investigate reliable biomarkers for predicting histological chorioamnionitis (HCA). Design: In this retrospective study, PPROM mothers were treated with a course of dexamethasone. Blood tests for serum indictors were conducted continuously after first injection. Setting: One Shanghai hospital Population: PPROM mothers …

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Effect of cell density on the malignant biological behavior of breast cancer by altering the subcellular localization of ANXA2 and its clinical implications

Jingtai Chen, Xiaohan Su, Qiao Wen Tan, Hongyu Pu et autres

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