Mengnan Yang

HDAC6-mediated PFKL deacetylation enhances aerobic glycolysis and promotes VSMC proliferation

Zhao-Kun Hu, Zhiyan Ren, Jie-Xin Pang, Hui Li et autres

Post-translational modifications (PTMs) of the glycolytic enzyme phosphofructokinase, liver type (PFKL) play a vital role in regulating its activity and function. Recently, we observed a reduction of PFKL acetylation in platelet-derived growth factor (PDGF)-BB-induced synthetic vascular smooth muscle cells (VSMCs). However, the …

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Mitochondrial‐Targeted Ultrasmall Hydrophobic Cationic Graphene Nanosheets Potentiating Tumor Photoimmunotherapy

Jiyuan Zhou, Mengnan Yang, Hengchuan Zhang, Tongyu Wu et autres

Abstract Mitochondria‐targeted drug delivery is a promising strategy to potentiate anti‐tumor efficacy. Current mitochondria‐targeting nano‐delivery strategies are mainly based on modification of lipophilic cation or targeting peptides. Due to endo/lysosomal capture and size limitation from mitochondrial outer membrane pores, neither approach guarantees …

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Sex dimorphic associations between oxidative stress and adiposity in early childhood

Zi-Lin Chen, Xin Liu, Minyi Tao, Mengnan Yang et autres

OBJECTIVE: Oxidative stress is suspected in the development of obesity. We sought to evaluate the relationship between oxidative stress and obesity/adiposity in early childhood, and explore potential sex dimorphic associations. DESIGN: Nested case-control study. METHODS: In a study of 120 pairs of …

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Glycoprotein Ibα‐Dependent Platelet Activation is Essential for Tumor Cell–Platelet Interaction and Experimental Metastasis

Kangxi Zhou, Qing Li, Yue Xia, Chenglin Sun et autres

Metastasis is the main cause of cancer-related deaths and the biggest challenge in improving cancer prognosis. Platelet-tumor cell aggregates are a prerequisite for hematogenous metastasis. However, the internal relation and molecular mechanism of platelets and their receptor glycoprotein (GP) Ibα in platelet-tumor …

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Iloprost Concentration‐Dependently Attenuates Platelet Function and Apoptosis by Elevating PKA Activity

Xuexiang Wang, Shuang Chen, Jun Wan, Chunliang Liu et autres

ABSTRACT Iloprost, a prostacyclin (PGI2) analogue, stimulates the IP receptor (PTGIR) to interact with the Gsα β/γ complex, leading to the activation of adenylate cyclase, which enzyme produces the second messenger cAMP. Elevation in cAMP triggers intracellular signalling events and regulates a …

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Gestational diabetes mellitus and linear growth in early childhood

Zi-Lin Chen, Xin Liu, Minyi Tao, Mengnan Yang et autres

Introduction: Gestational diabetes mellitus (GDM) is a common pregnancy complication with potential short- and long-term adverse consequences for both mothers and fetuses. It is unclear whether GDM affects linear growth in the offspring; research data are limited and inconsistent. Methods: In a …

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Prediction of gestational diabetes mellitus by multiple biomarkers at early gestation

Mengnan Yang, Lin Zhang, Wenjuan Wang, Rong Huang et autres

BACKGROUND: It remains unclear which early gestational biomarkers can be used in predicting later development of gestational diabetes mellitus (GDM). We sought to identify the optimal combination of early gestational biomarkers in predicting GDM in machine learning (ML) models. METHODS: This was …

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Cord Blood Fetuin-B, Fetal Growth Factors, and Lipids in Gestational Diabetes Mellitus

Wenjuan Wang, Hua He, Fang Fang, Xin Liu et autres

CONTEXT: Fetuin-B is a hepatokine/adipokine implicated in glucose homeostasis and lipid metabolism. OBJECTIVE: We sought to assess whether cord blood fetuin-B levels are altered in gestational diabetes mellitus (GDM) and the association with fetal growth factors and lipids. METHODS: In a nested, …

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Essential role of glycoprotein Ibα in platelet activation

Rong Yan, Yue Xia, Kangxi Zhou, Jun Liu et autres

ABSTRACT: Glycoprotein Ibα (GPIbα), the ligand-binding subunit of platelet GPIb-IX complex, interacts with von Willebrand factor (VWF) exposed at the injured vessel wall, initiating platelet adhesion, activation, hemostasis, and thrombus formation. The cytoplasmic tail of GPIbα interacts with 14-3-3ζ, regulating the VWF-GPIbα-elicited …

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Activation of AMPK in platelets promotes the production of offspring

Tong Zhang, Mengnan Yang, Shujun Li, Rong Yan et autres

Platelets are terminally differentiated anucleated cells, but they still have cell-like functions and can even produce progeny platelets.However, the mechanism of platelet sprouting has not been elucidated so far.Here, we show that when platelet-rich plasma(PRP) was cultured at 37°C, platelets showed a …

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Pregnancy Outcomes and Associated Factors for Uterine Rupture: A population-based retrospective study

Sheng Wan, Mengnan Yang, Jindan Pei, Xiaobo Zhao et autres

Objective To assess the incidence of uterine rupture, its association with previous uterine surgery and vaginal birth after a caesarean section (VBAC), and the maternal and perinatal implications. Design Population-based retrospective study. Setting Shanghai, China. Participants A total of 209,112 deliveries were …

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Fetal overgrowth and weight trajectories during infancy and adiposity in early childhood

Minyi Tao, Xin Liu, Zi-Lin Chen, Mengnan Yang et autres

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