Stephen Tolchard

Characterising recovery following abdominal aortic aneurysm repair using cardiopulmonary exercise testing and patient reported outcome measures

N Dodds, Johanna Angell, S. L. Lewis, Mark Pyke et autres

Purpose Surgery is associated with a post-operative stress response, changes in cardiopulmonary reserve, and metabolic demand. Here recovery after abdominal aortic aneurysm repair is investigated using cardiopulmonary exercise testing and patient-reported questionnaires.Materials and methods Patients undergoing open (n = 21) or endovascular …

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Characterising recovery from renal transplantation and live-related donation using cardiopulmonary exercise testing

Johanna Angell, Nicholas Dodds, Alia M Darweish-Mednuik, S M Lewis et autres

BACKGROUND: An association between end-stage renal failure and exercise intolerance exists. Whether live kidney donation impacts on exercise tolerance is unknown. Here recovery post renal transplant and donation using cardiopulmonary exercise testing is investigated. METHODS: = 24) undertook a cardiopulmonary exercise test, …

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Improving theatre turnaround time

Daniel A. Fletcher, David Edwards, Stephen Tolchard, Richard Baker et autres

The NHS Institute for Innovation and Improvement has determined that a £7 million saving can be achieved per trust by improving theatre efficiency. The aim of this quality improvement project was to improve orthopaedic theatre turnaround without compromising the patient safety. We …

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O-080: Correlation between age, physiological fitness and peri-operative risk

Johanna Angell, Stephen Tolchard, N Dodds, Sarah J. Lewis et autres

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Cardiopulmonary reserve as determined by cardiopulmonary exercise testing correlates with length of stay and predicts complications after radical cystectomy

Stephen Tolchard, Johanna Angell, Mark Pyke, S M Lewis et autres

OBJECTIVE: To investigate whether poor preoperative cardiopulmonary reserve and comorbid state dictate high-risk status and can predict complications in patients undergoing radical cystectomy (RC). PATIENTS AND METHODS: In all, 105 consecutive patients with transitional cell carcinoma (TCC; stage T1-T3) undergoing robot-assisted (38 …

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The Managing Emergencies in Paediatric Anaesthesia global rating scale is a reliable tool for simulation‐based assessment in pediatric anesthesia crisis management

Tobias Everett, Elaine Ng, Daniel Power, Christopher L. Marsh et autres

INTRODUCTION: The use of simulation-based assessments for high-stakes physician examinations remains controversial. The Managing Emergencies in Paediatric Anaesthesia course uses simulation to teach evidence-based management of anesthesia crises to trainee anesthetists in the United Kingdom (UK) and Canada. In this study, we …

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Efficacy of the subcostal transversus abdominis plane block in laparoscopic cholecystectomy: Comparison with conventional port-site infiltration

Stephen Tolchard, R. Davies, Sarah J. Martindale

BACKGROUND: Pain experienced following laparoscopic cholecystectomy is largely contributed by the anterior abdominal wall incisions. This study investigated whether subcostal transversus abdominis (STA) block was superior to traditional port-site infiltration of local anesthetic in reducing postoperative pain, opioid consumption, and time for …

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Hypothermic responses to infection are inhibited by α2-adrenoceptor agonists with possible clinical implications

Stephen Tolchard, P.A. Burns, D.J. Nutt, Stephen M. Fitzjohn

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Separate and Combined Effects of Morphine and Amphetamine on Quantitative Electroencephalogram and Regional Cerebral Glucose Uptake in a Rat Model

Jonathan J. Lipman, Stephen Tolchard

The effects of morphine (5 mg/kg) and amphetamine (5 mg/kg) were examined on relative regional cerebral glucose uptake (RrCGlu), surveyed in 20 brain areas in the rat. No relationship was found between drug effects on the cortical RrCGlu and the quantitative electroencephalogram …

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Modulation of synaptic transmission in the rat ventral septal area by the pharmacological activation of metabotropic glutamate receptors

Stephen Tolchard, Geoff Clarke, Graham L. Collingridge, Stephen M. Fitzjohn

The ventral septal area (VSA) is considered to be critically involved in the control of the height and duration of fever. The major excitatory input to this region of the brain is glutamatergic, and the aim of this study was to investigate …

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TNFα mimics the endocrine but not the thermoregulatory responses of bacterial lipopolysaccharide (LPS): Correlation with FOS-expression in the brain

Stephen Tolchard, Alice Hare, D.J. Nutt, G. Clarke

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Bacterial Lipopolysaccharide‐Induced Changes in FOS Protein Expression in the Rat Brain: Correlation with Thermoregulatory Changes and Plasma Corticosterone

Alice Hare, G. Clarke, Stephen Tolchard

In the present study the regions of the brain showing an increase in the number of FOS protein stained cells 180 min following intravenous saline or bacterial lipopolysaccharide (LPS) treatment were investigated and correlated with changes in body temperature and plasma corticosterone …

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