Geoff Clarke

Empagliflozin Reduces Liver Fat in Diabetic and Nondiabetic Subjects

Siham Abdelgani, Ahmed Khattab, John M. Adams, Gozde Baskoy et autres

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Empagliflozin Reduces Liver Fat in Diabetic and Nondiabetic Subjects

Siham Abdelgani, Ahmed Khattab, John M. Adams, Gozde Baskoy et autres

Objective: To examine the effect of empagliflozin on liver fat content in T2DM and nondiabetic individuals, and the relationship between the decrease in liver fat and other metabolic actions of empagliflozin. Research Design and Methods: 30 T2DM and 27 nondiabetic individuals were …

Empagliflozin Reduces Liver Fat in Diabetic and Nondiabetic Subjects

Siham Abdelgani, Ahmed Khattab, John M. Adams, Gozde Baskoy et autres

Objective: To examine the effect of empagliflozin on liver fat content in T2DM and nondiabetic individuals, and the relationship between the decrease in liver fat and other metabolic actions of empagliflozin. Research Design and Methods: 30 T2DM and 27 nondiabetic individuals were …

Empagliflozin Reduces Liver Fat in Individuals With and Without Diabetes

Siham Abdelgani, Ahmed Khattab, John M. Adams, Gozde Baskoy et autres

OBJECTIVE: To examine the effect of empagliflozin on liver fat content in individuals with and without type 2 diabetes (T2D) and the relationship between the decrease in liver fat and other metabolic actions of empagliflozin. RESEARCH DESIGN AND METHODS: Thirty individuals with …

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Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks

Scott A. Yuzwa, Guang Yang, Michael J. Borrett, Geoff Clarke et autres

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Computational Modeling and Stem Cell Engineering

Peter W. Zandstra, Geoff Clarke

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Predictive microfluidic control of regulatory ligand trajectories in individual pluripotent cells

Faisal Moledina, Geoff Clarke, Ali Oskooei, Kento Onishi et autres

Local (cell-level) signaling environments, regulated by autocrine and paracrine signaling, and modulated by cell organization, are hypothesized to be fundamental stem cell fate control mechanisms used during development. It has, however, been challenging to demonstrate the impact of cell-level organization on stem …

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Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics

Mark Ungrin, Geoff Clarke, Ting Yin, Sylvia Niebrügge et autres

We present a predictive bioprocess design strategy employing cell- and molecular-level analysis of rate-limiting steps in human pluripotent stem cell (hPSC) expansion and differentiation, and apply it to produce definitive endoderm (DE) progenitors using a scalable directed-differentiation technology. We define a bioprocess …

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One-hit stochastic decline in a mechanochemical model of cytoskeleton-induced neuron death II: Transition state metastability

Tatiana Lomasko, Geoff Clarke, Charles J. Lumsden

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One-hit stochastic decline in a mechanochemical model of cytoskeleton-induced neuron death I: Cell-fate arrival times

Tatiana Lomasko, Geoff Clarke, Charles J. Lumsden

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Caffeine Accelerates Absorption and Enhances the Analgesic Effect of Acetaminophen

Bertold Renner, Geoff Clarke, T. J. Grattan, Angelika Beisel et autres

The aim of this study was to determine the analgesic effect of acetaminophen compared to a combination of both caffeine and acetaminophen or caffeine alone using tonic and phasic pain stimulation. Twenty-four subjects were treated orally with 1000 mg acetaminophen, 130 mg …

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Scale-free neurodegeneration: cellular heterogeneity and the stretched exponential kinetics of cell death

Geoff Clarke, Charles J. Lumsden

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