Meltem Ayas

Proteomic remodeling of outer membrane vesicles in antibiotic-resistant Helicobacter pylori reveals adaptive stress responses

Tuana Nur Aydınlar, Sümeyye Akcelik-Deveci, Meltem Ayas, Sinem Öktem-Okullu

Background Antibiotic resistance in Helicobacter pylori has become a major obstacle to successful eradication therapy worldwide. Although outer membrane vesicles (OMVs) are increasingly recognized as key mediators of bacterial adaptation and host interaction, their contribution to antibiotic resistance in H. pylori remains …

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A Novel Antimicrobial Peptide Displaying Broad-Spectrum Activity Against Pan-Resistant Pathogens and Low Propensity for Resistance Development

Betül Zehra Temur, Esma Aybakan, Meltem Ayas, Sengül Nisa Demirci et autres

Objectives: The escalation of multidrug-resistant (MDR) clinically relevant bacterial isolates, including Escherichia coli and key ESKAPE pathogens, represents a critical global healthcare threat. While antimicrobial peptides (AMPs) offer promising alternatives, metabolic instability often limits their clinical use. This study investigated the therapeutic …

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Investigation of Trends in Tuberculosis Drug Resistance in Türkiye

Meltem Ayas, Aylin Suran, Ravel Deniz Saygı, Neval Yurttutan

Purpose: The emergence of drug-resistant Mycobacterium tuberculosis complex (MTC) strains poses a significant challenge to global tuberculosis (TB) control efforts. This study aimed to evaluate the trends of primary resistance to first-line anti-tuberculosis drugs among clinical MTC isolates obtained in Türkiye over …

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Olgu Sunumu: Düşük Doz Lidokain Konvülziyon Yapar mı?

Meltem Ayas, Berrin Işık