A Novel Antimicrobial Peptide Displaying Broad-Spectrum Activity Against Pan-Resistant Pathogens and Low Propensity for Resistance Development
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Le résumé fourni par la source
Objectives: The escalation of multidrug-resistant (MDR) clinically relevant bacterial isolates, including Escherichia coli and key ESKAPE pathogens, represents a critical global healthcare threat. While antimicrobial peptides (AMPs) offer promising alternatives, metabolic instability often limits their clinical use. This study investigated the therapeutic potential, antimicrobial efficacy, and resistance dynamics of peptide D-TN6 against highly resistant bacterial strains. Methods: D-TN6 efficacy was evaluated against 164 clinical isolates, including pan-drug-resistant, carbapenem-resistant, and polymyxin-resistant phenotypes. A 20-passage serial induction assay compared resistance development kinetics of D-TN6 against gentamicin over an extended period. Results: D-TN6 demonstrated potent efficacy against MRSA (minimum inhibitory concentration (MIC)90: 1 µg/mL) and remained effective against polymyxin B-resistant Klebsiella pneumoniae (MIC90: 8 µg/mL) and pan-drug-resistant Acinetobacter baumannii (MIC90: 8 µg/mL). In resistance assays, while the gentamicin MIC increased 256-fold by the 17th passage, the D-TN6 MIC remained constant at 1 µg/mL throughout the 20-passage study. Conclusions: These findings underscore D-TN6 as a robust therapeutic candidate. Its efficacy against MDR strains and its feature of low propensity for resistance development—likely due to membrane disruption—position D-TN6 as a promising solution for life-threatening infections where conventional last-resort agents fail.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- A Novel Antimicrobial Peptide Displaying Broad-Spectrum Activity Against Pan-Resistant Pathogens and Low Propensity for Resistance Development
- Date Crossref
- 20/08/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Acıbadem University pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Natural and Applied Sciences Department of Biomedical Engineering pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Health Sciences Department of Medical Biotechnology pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Department of Medical Microbiology pays non établi dans la noticeUniversité ou école supérieure
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Vocational School of Health Services Medical Laboratory Techniques pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Engineering and Natural Sciences Department of Biomedical Engineering pays non établi dans la noticeUniversité ou école supérieure
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Acibadem Labmed Clinical Laboratory pays non établi dans la noticeStructure de recherche
Acıbadem University, Department of Biomedical Engineering — Graduate School of Natural and Applied Sciences et Department of Medical Biotechnology — Graduate School of Health Sciences, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.