Tu T. Nguyen

Histopathologic Spectrum of Primary Cutaneous T-Cell Lymphomas: Insights From a Vietnamese Case Series

Giang Huong Tran, Tu T. Nguyen, Khoa Anh Luong, Tho Ngoc-Quynh Le

BACKGROUND: Primary cutaneous T-cell lymphomas (PCTCLs) are a rare and heterogeneous group of extranodal non-Hodgkin lymphomas originating from skin-homing T cells. Most current knowledge about PCTCLs is derived from Western populations, with limited data available from Southeast Asia, including Vietnam. OBJECTIVE: To …

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Modifier Effects of APOE E2 and E4 Alleles on the age at onset of Alzheimer Disease in Puerto Rican G206A Mutation Carriers: A Family‐Based Study

Balaji Kannappan, Rong Cheng, Tu T. Nguyen, Ivonne Z. Jiménez‐Velázquez et autres

Abstract Background APOE E4 (APOE4 henceforth) is recognized as a major genetic risk factor for late‐onset Alzheimer's disease (AD), with its impact varying across ethnic subgroups. We investigate the risk of APOE4 and the protective effect of APOE E2 (APOE2 henceforth) in …

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Abstract 12927: Impact of AAV- MYBPC3 Gene Transfer on Heart Structure and Function in Human and Mouse Models of Hypertrophic Cardiomyopathy

Catherine Vitelli, Lening Zhang, Ryan Murphy, Bartlomiej J. Blus et autres

Background: Hypertrophic cardiomyopathy (HCM) is a life-threatening inherited heart disease characterized by left ventricular hypertrophy and diastolic dysfunction. The most common cause of HCM is genetic variants in MYBPC3 , encoding cardiac myosin binding protein C (cMyBP-C), a sarcomeric protein with structural …

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Abstract MP250: Reduction In Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator (arnt) Mediates Vascular Dysfunction In Mice With Type 2 Diabetes Mellitus

Tu T. Nguyen, Kaichao Pan, Maura Knapp, Mei Zheng et autres

Background: Endothelial dysfunction, especially at the microvasculature level, is one of the most deleterious events in diabetes. ARNT is a transcription factor that functions as a master regulator of glucose homeostasis, but its role in diabetic vascular complications is poorly understood. Results …

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The Effects of Medicare on Health-Care Utilization and Spending Among the Elderly

Pinka Chatterji, Tu T. Nguyen, Barış K. Yörük

We exploit the discontinuity in health insurance coverage rates at the Medicare eligibility age of 65 to investigate the impact of Medicare on health-care utilization and spending among the elderly. We find that the discrete change in insurance coverage rates at age …

Aging out of dependent coverage and the effects on the use of inpatient medical care

Tu T. Nguyen, Barış K. Yörük

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Essays on the effects of public health insurance policies on health care utilization, expenditure, and well-being

Tu T. Nguyen

This dissertation consists of essays on the causal impact of public health insurance policies in the United States. Three chapters investigate how Medicare program, Medicare Prescription coverage program, and the Affordable Care Act Medicaid expansion impact on health-related outcomes, health care expenditure, …

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New strategies for the development of lipid-lowering therapies to reduce cardiovascular risk

Ian Graham, C.L. Shear, Pieter de Graeff, Caroline Boulton et autres

The very high occurrence of cardiovascular events presents a major public health issue, because treatment remains suboptimal. Lowering LDL cholesterol (LDL-C) with statins or ezetimibe in combination with a statin reduces major adverse cardiovascular events. The cardiovascular risk reduction in relation to …

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ALIROCUMAB REDUCES MAJOR CARDIOVASCULAR EVENTS IN INDIVIDUALS WITH ATHEROSCLEROTIC CARDIOVASCULAR DISEASE: A POST-HOC ANALYSIS OF ODYSSEY LONG TERM

Jennifer A. Robinson, Michel Farnier, William J. Sasiela, Tu T. Nguyen et autres

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A Quantitative Systems Pharmacology Platform to Investigate the Impact of Alirocumab and Cholesterol-Lowering Therapies on Lipid Profiles and Plaque Characteristics

Jeffrey E. Ming, Ruth E. Abrams, Derek W. Bartlett, Mengdi Tao et autres

Reduction in low-density lipoprotein cholesterol (LDL-C) is associated with decreased risk for cardiovascular disease. Alirocumab, an antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), significantly reduces LDL-C. Here, we report development of a quantitative systems pharmacology (QSP) model integrating peripheral and liver …

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Methadone Toxicity Due to Smoking Cessation—A Case Report on the Drug-Drug Interaction Involving Cytochrome P450 Isoenzyme IA2

Joy Wahawisan, Srikanth Kolluru, Tu T. Nguyen, Christina Molina et autres

OBJECTIVE: To report the potential clinically significant pharmacokinetic interaction that may result from smoking cessation in patients on methadone maintenance therapy. CASE SUMMARY: A 46-year-old white man was admitted to the step-down intensive care unit with decreased respirations and altered mental status …

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The pharmacokinetics of PF‐734200, a DPP‐IV inhibitor, in subjects with renal insufficiency

Haiqing Dai, Susan Johnson, Steven G. Terra, Thomas Marbury et autres

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Data demonstrating the pharmacokinetics (PK), efficacy and tolerability of PF‐734200, a potent DPP‐IV inhibitor in subjects with normal renal function, have been published or presented. WHAT THIS STUDY ADDS • This study provides better …

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