E‐L Larsson‐Sciard

Relationship between Changes in Thymic Emigrants and Cell-Associated HIV-1 Dna in HIV-1-Infected Children Initiating Antiretroviral Therapy

Anita De Rossi, Ann Sarah Walker, Davide De Forni, Nigel J. Klein et autres

OBJECTIVES AND METHODS: To investigate the relationship between cell-associated HIV-1 dynamics and recent thymic T-cell emigrants, HIV-1 DNA and T-cell receptor rearrangement excision circles (TREC, a marker of recent thymic emigrants) were measured in peripheral blood mononuclear cells in 181 samples from …

it, gb, nl (code pays fourni par la source)

T-cell re-population in HIV-infected children on highly active anti-retroviral therapy (HAART)

Doug King, F Gotch, E‐L Larsson‐Sciard

In this pilot study, we address the nature of the re-population of the T-cell compartment in HIV-1+ (Human Immunodeficiency Virus 1), vertically infected children placed on successful regimens of HAART (highly active anti-retroviral therapy) incorporating 2 NRTI and a protease inhibitor. The …

gb (code pays fourni par la source)

Molecular correlates in AIDS patients following antiretroviral therapy: diversified T‐cell receptor repertoires and in vivo control of cytomegalovirus replication

Stephanie Worrell, Jane R Deayton, Peter Hayes, Vincent C. Emery et autres

OBJECTIVES: To evaluate whether successful, long-term immune reconstitution in vivo can be achieved in end-stage AIDS patients following antiretroviral therapy (ART). METHODS: A 1-year prospective study of changes of CD4+ and CD8+ T-cell surface phenotypes, T-cell receptor (TCR) repertoires and capacity to …