Glenn Hernández

Weight-normalized norepinephrine dosing and apparent BMI-dependent vasopressin responsiveness

Pedro D. Wendel–Garcia, Sebastian Morales, Paulo Melo, Greta Emilia Kiavialaitis et autres

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Ability of diastolic arterial pressure to better characterize the severity of septic shock when adjusted for heart rate and norepinephrine dose

Antoine Goury, Zoubir Djerada, Glenn Hernández, Eduardo Kattan et autres

Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock

Fernando Pálizas, Bernardo Lattanzio, Natalia Durandal, María Eugenia Alonso et autres

Importance: The optimal strategy for hemodynamic resuscitation in early septic shock remains uncertain. Objective: To determine the effect of a personalized hemodynamic resuscitation protocol targeting capillary refill time (CRT-PHR) on a hierarchical composite outcome of mortality, duration of vital support, and length …

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Assessment of Tissue Perfusion Pressure in Patients With Septic Shock: Beyond Mean Arterial Pressure

Carlos Sánchez Escalante, Ahmed Taha Abdelsattar, Yasser Tolba, Glenn Hernández et autres

OBJECTIVES: Optimization of macrohemodynamics is just the starting point in the management of hemodynamics in patients with septic shock. We describe the interaction between the various determinants of arterial pressure and tissue perfusion, how to optimize them and their estimations at the …

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Can we reliably use pulse pressure as a surrogate for stroke volume? Physiological background and potential clinical implications for shock resuscitation

Zbigniew Putowski, Jean–Louis Teboul, Ricardo Castro, D. S. Chemla et autres

In critically ill patients, early hemodynamic assessment is essential for guiding shock resuscitation. While cardiac output (CO) is a key indicator of circulatory status, its measurement is often limited by technical and practical constraints. This perspective explores the physiological and clinical relevance …

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Capillary refill time as an additional triage criterion to decide ICU admission of deteriorating obstetric patients

Enrique Monares Zepeda, Sebastián Morales, Marco Antonio Heras Garate, Jesús Carlos Briones Garduño et autres

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Exploring Macro-to-Microcirculatory Coupling Through the Vasopressor Test in Septic Shock Patients

Emilio Daniel Valenzuela, Pablo Lázaro y De Mercado, Vanesa Oviedo, Macarena Amthauer et autres

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Exogenous corticosteroid-induced modulation of RAAS: potential implications for septic shock biomarker analysis

Thomas Uslar, Benjamín Sanfuentes, Rene F. Baudrand, Glenn Hernández et autres

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Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study

Luis Felipe Reyes, Alejandro H. Rodríguez, Yuli V. Fuentes, Sara Duque et autres

Around one-third of patients diagnosed with COVID-19 develop a severe illness that requires admission to the Intensive Care Unit (ICU). In clinical practice, clinicians have learned that patients admitted to the ICU due to severe COVID-19 frequently develop ventilator-associated lower respiratory tract …

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Clinical characteristics, systemic complications, and in-hospital outcomes for patients with COVID-19 in Latin America. LIVEN-Covid-19 study: A prospective, multicenter, multinational, cohort study

Luis Felipe Reyes, Alirio Bastidas, Paula O. Narváez, Daniela Parra-Tanoux et autres

PURPOSE: The COVID-19 pandemic has spread worldwide, and almost 396 million people have been infected around the globe. Latin American countries have been deeply affected, and there is a lack of data in this regard. This study aims to identify the clinical …

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Dexamethasone as risk-factor for ICU-acquired respiratory tract infections in severe COVID-19

Luis Felipe Reyes, Alejandro H. Rodríguez, Alirio Bastidas, Daniela Parra-Tanoux et autres

PURPOSE: Dexamethasone is the only drug that has consistently reduced mortality in patients with COVID-19, especially in patients needing oxygen or invasive mechanical ventilation. However, there is a growing concern about the relation of dexamethasone with the unprecedented rates of ICU-acquired respiratory …

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[Systemic leptospirosis as a cause of multiple organ failure. Report of a case].

Reinaldo Martínez Garrido, Luis Castillo, Glenn Hernández, Jacob Abarca et autres

Leptospirosis is a world-spread zoonosis that is incidentally acquired by humans. It causes a diphasic febrile illness in which the Weil syndrome is its severest form, with renal, hepatic, clotting and central nervous system involvement. We report a 73 years old male, …

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